Aerosol precursor containing effective components of oral drug for treating rhinitis and method for dispersing effective components into nanoscale droplets

A medicinal ingredient and aerosol technology, which is applied in the field of aerosol precursors, can solve the problems of high production cost, reduced pressure in the tank, and increased use cost, etc.

Inactive Publication Date: 2015-06-10
CHINA TOBACCO YUNNAN IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The representative patent for pressurized atomization of traditional Chinese medicine compound preparations is CN102949573A, in which an 80-100bar propellant such as trichlorofluoromethane, dichlorodifluoromethane or dichlorotetrafluoroethane is used to atomize the liquid medicine to To obtain micron-sized mist droplets, the above-mentioned injection pressure is too high...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] An aerosol precursor comprising an orally administered pharmaceutical active ingredient for treating rhinitis, which comprises glycerin, propylene glycol, 1,3-butanediol, flavoring substances and a syrup extract for treating rhinitis, and their mass ratio is Triol: propylene glycol: syrup extract for rhinitis = 40:20:1.

[0055] Wherein the oral drug extract for the treatment of rhinitis is obtained by the method comprising the following steps:

[0056] (1) Impurity removal: Dissolving Qinzhi rhinitis syrup (rhinitis syrup) in food-grade ethanol, filtering, removing insoluble impurities, and obtaining the ethanol solution of the syrup for treating rhinitis;

[0057] (2) decolouring: the ethanol solution of the syrup for the treatment of rhinitis obtained in step (1) is passed through the first macroporous resin chromatographic column, and is 50 volume % ethanol-water solution eluting with concentration, removes the pigment component wherein; The model of the first macr...

Embodiment 2

[0062] An aerosol precursor comprising an orally administered medicinal ingredient for treating rhinitis, which comprises glycerin, propylene glycol, 1,3-butanediol, flavoring substances and tablet extracts for treating rhinitis, and their mass ratio is Glycerol: propylene glycol: tablet extract for rhinitis = 40:20:1.

[0063] Wherein the oral drug extract for the treatment of rhinitis is obtained by the method comprising the following steps:

[0064] (1) Impurity removal: Grind Qianbai Biyan Tablets into powder and dissolve them in food-grade ethanol, filter to remove insoluble impurities, and obtain the ethanol solution of tablets for treating rhinitis;

[0065] (2) Decolorization: the ethanol solution of the tablet for treating rhinitis obtained in step (1) is passed through the first macroporous resin chromatographic column, and is eluted with an ethanol-water solution with a concentration of 50% by volume to remove the pigment component therein; The model of the first m...

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Abstract

The invention relates to an aerosol precursor containing effective components of an oral drug for treating rhinitis. The aerosol precursor comprises glycerine, propylene glycol, 1,3 butanediol, flavor components and oral dug extract for treating rhinitis, wherein the mass ratio of the glycerine to the propylene glycol to the 1,3 butanediol to the flavor components to the oral dug extract for treating rhinitis is (40-45):(20-25):(0-10):(0-10):(1-10). The invention further relates to a method for dispersing the effective components of the oral drug for treating rhinitis into nanoscale droplets, and an aerosol containing nanoscale droplets. The aerosol precursor contains the effective components of the oral drug for treating rhinitis, is placed in an electronic cigarette utensil containing an electric heating device to be heated to produce nanoscale droplets, and the human body can better absorb the effective components.

Description

technical field [0001] The invention relates to an aerosol precursor, in particular to an aerosol precursor containing an orally administered medicinal ingredient for treating rhinitis and a method for dispersing it into nano-scale droplets. Background technique [0002] Rhinitis is an inflammatory disease of the nasal cavity, which is the inflammation of the nasal mucosa caused by viruses, bacteria, allergens, various physical and chemical factors, and certain systemic diseases. The main pathological changes of rhinitis are congestion, swelling, exudation, hyperplasia, atrophy or necrosis of nasal mucosa. At present, the traditional Chinese medicine compound preparation for the treatment of rhinitis includes oral medication for the treatment of rhinitis. Usually, the administration method of the oral medication for the treatment of rhinitis is oral administration. On the one hand, the drug effect of this administration method is slow; Irritation to the stomach; on the othe...

Claims

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Application Information

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IPC IPC(8): A61K9/12A61K47/10A61K45/00A61P11/02
Inventor 缪明明赵伟杨柳尚善斋韩敬美雷萍段沅杏杨继田永峰汤建国郑绪东陈永宽
Owner CHINA TOBACCO YUNNAN IND
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