Aerosol precursor containing effective components of oral drug for treating rhinitis and method for dispersing effective components into nanoscale droplets
A medicinal ingredient and aerosol technology, which is applied in the field of aerosol precursors, can solve the problems of high production cost, reduced pressure in the tank, and increased use cost, etc.
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Embodiment 1
[0054] An aerosol precursor comprising an orally administered pharmaceutical active ingredient for treating rhinitis, which comprises glycerin, propylene glycol, 1,3-butanediol, flavoring substances and a syrup extract for treating rhinitis, and their mass ratio is Triol: propylene glycol: syrup extract for rhinitis = 40:20:1.
[0055] Wherein the oral drug extract for the treatment of rhinitis is obtained by the method comprising the following steps:
[0056] (1) Impurity removal: Dissolving Qinzhi rhinitis syrup (rhinitis syrup) in food-grade ethanol, filtering, removing insoluble impurities, and obtaining the ethanol solution of the syrup for treating rhinitis;
[0057] (2) decolouring: the ethanol solution of the syrup for the treatment of rhinitis obtained in step (1) is passed through the first macroporous resin chromatographic column, and is 50 volume % ethanol-water solution eluting with concentration, removes the pigment component wherein; The model of the first macr...
Embodiment 2
[0062] An aerosol precursor comprising an orally administered medicinal ingredient for treating rhinitis, which comprises glycerin, propylene glycol, 1,3-butanediol, flavoring substances and tablet extracts for treating rhinitis, and their mass ratio is Glycerol: propylene glycol: tablet extract for rhinitis = 40:20:1.
[0063] Wherein the oral drug extract for the treatment of rhinitis is obtained by the method comprising the following steps:
[0064] (1) Impurity removal: Grind Qianbai Biyan Tablets into powder and dissolve them in food-grade ethanol, filter to remove insoluble impurities, and obtain the ethanol solution of tablets for treating rhinitis;
[0065] (2) Decolorization: the ethanol solution of the tablet for treating rhinitis obtained in step (1) is passed through the first macroporous resin chromatographic column, and is eluted with an ethanol-water solution with a concentration of 50% by volume to remove the pigment component therein; The model of the first m...
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