Vaterite calcium carbonate microspheres and preparation method thereof

A calcium carbonate and vaterite technology, applied in the field of biomedical materials, can solve problems such as waste water pollution in silk reeling plants, and achieve the effects of high biodegradability, high biocompatibility and good dispersibility

Inactive Publication Date: 2015-06-10
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The sericin used can be extracted from the wastewater of the silk reeling factory, which solves

Method used

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  • Vaterite calcium carbonate microspheres and preparation method thereof
  • Vaterite calcium carbonate microspheres and preparation method thereof
  • Vaterite calcium carbonate microspheres and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Preparation of the calcium salt solution: Dissolve 2 mol of anhydrous calcium chloride in 1 L of deionized water to obtain a calcium chloride solution with a concentration of 2 mol / L for later use.

[0031] (2) Preparation of sodium carbonate aqueous solution: Dissolve 2 mol of sodium carbonate in 1L of deionized water to obtain a sodium carbonate solution with a concentration of 2 mol / L for later use.

[0032] (3) Sericin solution configuration: Take 25 mL of the above concentrated sericin solution concentrated to 30 mg / mL, and add 125 mL of deionized water. , to prepare 150 mL of sericin solution with a concentration of 5 mg / mL.

[0033] (4) Add 5 mL of the calcium chloride solution in step (1) and 5 mL of the sodium carbonate solution in step (2) dropwise into the sericin solution prepared in step (3) under stirring conditions, Stirring was continued for half an hour after the dropwise addition.

[0034] (5) The obtained precipitate was taken out by centrifugat...

Embodiment 2

[0036] Change the configuration of the calcium salt solution in step (1) to: 2 mol of calcium nitrate, dissolved in 1L of deionized water, to obtain a calcium nitrate solution with a concentration of 2 mol / L, and set aside.

[0037] Subsequent steps are the same as in Example 1, and the obtained product has a particle size of about 1.3 μm microspheres, and the vaterite crystal content is greater than 80%.

Embodiment 3

[0039] Change the configuration of the carbonate solution in step (2) to: 2 mol of potassium carbonate is dissolved in 1 L of deionized water to obtain a potassium carbonate solution with a concentration of 2 mol / L for later use.

[0040] Subsequent steps are the same as in Example 1, and the obtained product has a particle size of about 1.2 μm microspheres, and the vaterite crystal content is greater than 80%.

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Abstract

The invention discloses a method for simply preparing vaterite calcium carbonate microspheres. The preparation method comprises the steps of 1, preparing a sericin solution; 2, preparing a sericin solution with a certain concentration as a template regulation system through the dialyzed sericin solution according to the chemical equation shown in the specification, and dropping calcium salt and carbonate which have the same concentration into a reaction system in a certain proportion; 3, agitating the reaction system for a period of time, centrifuging to remove precipitate, and washing with water at three times; 4, drying the CaCO3 precipitate through a drying box after water washing, so as to obtain the finished product of vaterite calcium carbonate microspheres. The granularity of the CaCO3 microspheres is 1 to 1.5 microns; the vaterite calcium crystal form in the obtained material is more than 80%; the natural sericin solution is used as the template regulation system to regulate CaCO3 crystal form.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to the preparation and application of a vaterite-phase calcium carbonate microsphere, in particular to a method of synthesizing vaterite crystal-form calcium carbonate under the condition of using sericin as a template microsphere method. Background technique [0002] Biomineralization is a physical and chemical process with mild conditions, low energy consumption, and no pollution. Therefore, the mineralization mechanism regulated by organic matter can be used for effective biomimetic synthesis of organic and inorganic composite materials in vitro. Biomineralized materials are formed by living organisms leading organic matter to regulate the growth of inorganic substances, and generally have fine microstructures. These unique structures endow them with incomparable properties that conventional pure inorganic materials can induce. Biopolymers of different structures can be induce...

Claims

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Application Information

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IPC IPC(8): C01F11/18
CPCC01F11/183C01P2002/72C01P2002/82C01P2004/03C01P2004/32C01P2004/61
Inventor 田保祥吴轩奇陈菲郎思睿孔祥东
Owner ZHEJIANG SCI-TECH UNIV
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