A green method for the synthesis of 1,3,5-trisubstituent-2-pyrazoline derivatives catalyzed by ionic liquids

An ionic liquid, tri-substituted technology, applied in chemical instruments and methods, chemical/physical processes, physical/chemical process catalysts, etc., can solve the problems of long reaction time, low yield, complicated post-processing, etc., and reduce the reaction time. , reduced usage, easy post-processing effects
CN104693120BInactive Publication Date: 2017-03-22SHANDONG NORMAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANDONG NORMAL UNIV
Publication Date
2017-03-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to an environmental-friendly method for catalytic synthesis of a 1,3,5-triple substituent-2-pyrazoline derivative through ionic liquid. The method comprises the following steps: mixing a chalcone derivative, a substituted hydrazine and an ionic liquid catalyst under solvent-free conditions, ultrasonically oscillating and dissolving, heating, refluxing, stirring and reacting at the temperature of 50-60 DEG C for 0.5-1 hour, cooling, filtering and recrystallizing the reaction solution, thereby obtaining the product, wherein the molar ratio of the chalcone derivative to the substituted hydrazine to the ionic liquid catalyst is 1:(1.2-1.5):(3-6). According to the preparation method disclosed by the invention, a solvent is not needed, the reaction time is reduced by a half, the reactants are synthesized under the catalysis action of the functional ionic liquid, the functional ionic liquid can be recycled, use of an organic reagent is greatly reduced, the reaction temperature is reduced from the original about 110 DEG C to about 50 DEG C, the aftertreatment is relatively simple, and energy conservation and high efficiency of environment-friendly chemical synthesis can be realized.
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Description

technical field

[0001] The invention relates to a new method for synthesizing 1,3,5-trisubstituent-2-pyrazoline derivatives, belonging to the technical field of chemical synthesis. Background technique

[0002] 2-Pyrazoline compounds are an important class of nitrogen-containing heterocyclic compounds, and their derivatives have good physiological and pharmacological activities in pesticides and medicines, including antibacterial, antidepressant, anticonvulsant, antiviral, anti-tuberculosis, Inhibit immunity, insecticide and herbicide, among which 1-acetyl-3,5-diaryl-2-pyrazoline derivatives can inhibit the synthesis of monoamine converting enzymes. Therefore, the synthesis and application of 1,3,5-trisubstituent-2-pyrazoline have attracted widespread attention. On the other hand, pyrazoline compounds are also widely used in the field of optoelectronics because of their strong fluorescence, especially in optical brighteners and dyes for paper materials and textiles, especia...

Claims

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