A titanium dioxide-carbon rod microelectrode, its preparation method and its application in detecting the concentration of acetaminophen in blood

A technology of titanium dioxide and microelectrodes, applied in the field of electrochemical analysis and detection, to achieve high sensitivity, good electroactivity, and simple preparation process

Inactive Publication Date: 2017-05-24
南京嘉美清丽环境科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there have been many reports on electrochemical sensors based on carbon electrodes and their applications.

Method used

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  • A titanium dioxide-carbon rod microelectrode, its preparation method and its application in detecting the concentration of acetaminophen in blood
  • A titanium dioxide-carbon rod microelectrode, its preparation method and its application in detecting the concentration of acetaminophen in blood
  • A titanium dioxide-carbon rod microelectrode, its preparation method and its application in detecting the concentration of acetaminophen in blood

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A preparation method of titanium dioxide-carbon rod microelectrode, the steps are as follows:

[0035] Carbon rod pretreatment: Soak a carbon rod with a diameter of 0.5 mm and a length of 20 mm in 98% concentrated sulfuric acid, take it out after activation, wash it with deionized water for 3 to 5 times, and place it to dry at room temperature.

[0036] Mix 0.02mol of titanium powder and 0.05mol of ammonium chloride powder in a mortar and put them into a crucible. Next, the crucible was placed in a muffle furnace and reacted at 400° C. for 3 hours. Finally, titanium dioxide powder was obtained after cooling at room temperature.

[0037] 10 mg of titanium dioxide powder was ultrasonically dispersed in 5 mL of deionized water to form a homogeneous dispersion. Then the resulting dispersion was mixed with the pretreated carbon rod and placed in a 30 mL polytetrafluoroethylene autoclave, reacted at 200° C. for 6 hours, cooled and then taken out and dried at room temperatur...

Embodiment 2

[0040] A preparation method of titanium dioxide-carbon rod microelectrode, the steps are as follows:

[0041] Carbon rod pretreatment: Soak a carbon rod with a diameter of 0.5 mm and a length of 20 mm in 36.5% concentrated hydrochloric acid, take it out after activation, wash it with deionized water for 3 to 5 times, and place it to dry at room temperature.

[0042] Mix 0.02mol of titanium powder and 0.06mol of ammonium chloride powder in a mortar and put them into a crucible. Next, the crucible was placed in a muffle furnace and reacted at 300° C. for 4 hours. Finally, titanium dioxide powder was obtained after cooling at room temperature.

[0043] 8 mg of titanium dioxide powder were ultrasonically dispersed in 5 mL of deionized water to form a homogeneous dispersion. Then the resulting dispersion was mixed with the pretreated carbon rod and placed in a 30 mL polytetrafluoroethylene autoclave, reacted at 150° C. for 8 hours, cooled and then taken out and dried at room temp...

Embodiment 3

[0045] A preparation method of titanium dioxide-carbon rod microelectrode, the steps are as follows:

[0046] Carbon rod pretreatment: Soak a carbon rod with a diameter of 0.5 mm and a length of 20 mm in 69% concentrated nitric acid, take it out after activation, wash it with deionized water for 3 to 5 times, and place it to dry at room temperature.

[0047] Mix 0.02mol of titanium powder and 0.08mol of ammonium chloride powder in a mortar and put them into a crucible. Next, the crucible was placed in a muffle furnace and reacted at 200° C. for 5 hours. Finally, titanium dioxide powder was obtained after cooling at room temperature.

[0048] Ultrasonic dispersion of 5 mg of titanium dioxide powder in 5 mL of deionized water formed a homogeneous dispersion. Then the resulting dispersion was mixed with the pretreated carbon rod and placed in a 30 mL polytetrafluoroethylene autoclave, reacted at 100° C. for 10 hours, cooled and then taken out and dried at room temperature. One...

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Abstract

The invention discloses a titanium dioxide-carbon rod microelectrode, a preparation method and the application thereof for detecting the concentration of acetaminophen in blood. The electrode comprises a carbon rod and a copper wire, the carbon rod is connected with the copper wire through silver conducting adhesives, and titanium dioxide is loaded on the carbon rod. The preparation method comprises the steps that titanium powder and ammonium chloride powder which are evenly mixed are heated at high temperature to obtain the titanium dioxide, ultrasonic dispersion is performed on the titanium dioxide in deionized water, and finally one end of the carbon rod is fixed with the copper wire by using the conducting adhesives to obtain the carbon rod microelectrode modified by the titanium dioxide. The preparation raw materials of the titanium dioxide-carbon rod microelectrode are simple, easy to obtain, non-poisonous and environmental-friendly and low in cost; the modified electrode can be used for detecting the content of the acetaminophen in the blood, and has the advantages of being fast in response time, wide in linear range, low in detection limit, good in reproducibility and high in stability and the like.

Description

technical field [0001] The invention belongs to the technical field of electrochemical analysis and detection, and specifically relates to a titanium dioxide-carbon rod microelectrode, a preparation method and an application for detecting the concentration of acetaminophen in blood. Background technique [0002] Acetaminophen (paracetamol) is a widely used analgesic that can effectively relieve joint pain, neuralgia, migraine, cancer pain, headache, backache and postoperative pain. Under normal circumstances, normal use of acetaminophen has no toxic effect on the human body, but if a large amount of acetaminophen is used for a long time, or used together with alcohol and other drugs, it will cause skin rashes, liver disorders, kidney and pancreas damage. inflammation. Therefore, a simple, rapid and economical and reliable method to accurately detect the content of acetaminophen in blood is of great significance. [0003] At present, various methods have been used to determ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/30G01N27/48C01G23/08
Inventor 白雪黄欣张琪华祖林顾海鑫戴章艳唐志强
Owner 南京嘉美清丽环境科技有限公司
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