Production process of effectively extracting heparin sodium

Abstract

The invention relates to a production process of effectively extracting heparin sodium. According to the production process, with the valence of a heparin sodium final product as an index and porcine intestinal mucosa as a raw material, heparin sodium (anticoagulant drug) with high valence is extracted through a production process method comprising the steps of enzymolysis, resin adsorption / elution, membrane separation, ethanol precipitation and drying. Compared with the traditional method comprising the steps of salt resolving, ion exchange and ethanol precipitation, the method disclosed by the invention has the advantages that an enzymolysis and membrane separation technology is effectively combined with a precipitation technology so that the valence of the extracted heparin sodium can be effectively increased to 160 U / mg and improved by nearly 64 percent, and the final recovery rate is improved by 29 percent. Meanwhile, a subsequent refining process can be shortened, the production cost is reduced, and the separation yield and the separation efficiency of heparin sodium can be improved.

Description

(1) Technical field [0001] The invention relates to a method for efficiently extracting heparin sodium, in particular to a production process for efficiently extracting heparin sodium by utilizing an enzyme method in combination with membrane separation technology and precipitation technology. (2) Background technology [0002] Heparin is an acidic mucopolysaccharide composed of D-glucosamine, D-glucuronic acid, N-acetylglucosamine and L-iduronic acid, widely present in mammalian intestinal mucosa, heart , liver, lung, blood, pancreas, and placenta. It has good anticoagulant, hypolipidemic, fibrinolytic and anti-medial smooth muscle cell proliferation activities, and is widely used in the treatment of cardiovascular and cerebrovascular diseases. Heparin sodium is the sodium salt form of heparin, which is prepared in the form of sodium salt during the extraction process of heparin, which is convenient for the preservation of drug efficacy and activity, and can be used as a p...

AI Technical Summary

Problems solved by technology

However, the heparin sodium produced by this process has low yield and low potency, and the acquisition of high-quality heparin sodium requires complex oxidation, purification and other processes, which are cumbersome and costly.