Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Micro-fluidic chip, vinyl-thiol polymeric material for micro-fluidic chip and preparation method

A polymer material, vinyl technology, applied in the modification of internal structure and surface hydrophilic/hydrophobicity, the preparation of microfluidic chip materials, can solve the problems of lack of hydrophilicity and hydrophobicity, material deformation, surface failure, etc., and it is not easy to achieve. The effect of batch processing, easy batch production, and simple method

Inactive Publication Date: 2015-06-24
SHANGHAI JIAO TONG UNIV
View PDF1 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are some problems when combining two or more layers of polymers in the microfluidic control chip: on the one hand, since the microfluidic control chip is usually treated with heat treatment, solvent treatment or oxygen plasma before bonding, this treatment method will Deactivation of pre-biomodified surfaces or oxidation of sputtered gold surfaces; on the other hand, polymer-to-polymer or polymer-to-substrate (such as glass) bonding, if both parts are relatively hard and the surface is insufficient Slippery can cause seal failure, while mechanically clamping softer materials can deform the material potentially causing fluid leakage or changing fluid properties
However, the patent and literature do not mention the technology of preparing and assembling vinyl-mercapto materials containing microchannel structures using non-ideal stoichiometric ratios, and there is no method for modifying the hydrophilicity and hydrophobicity of the materials in the later stage.
And so far, there are few other literature reports and scientific research work on similar materials

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Micro-fluidic chip, vinyl-thiol polymeric material for micro-fluidic chip and preparation method
  • Micro-fluidic chip, vinyl-thiol polymeric material for micro-fluidic chip and preparation method
  • Micro-fluidic chip, vinyl-thiol polymeric material for micro-fluidic chip and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] The preparation of embodiment 1 OSTE material

[0047] Take mercapto 70 as an example, where "mercapto" means that the excess material in the composite material is a mercapto-containing material, and "70" means that the proportion exceeding the stoichiometric ratio is 70%.

[0048] Weigh 0.664g pentaerythritol tetramercaptoacetate, 0.300g 1,3,5-triallyl-1,3,5-triazine-2,4,6(1H,3H,5H )-triketone, 0.005g phenyl bis(2,4,6-trimethylbenzoyl) phosphine oxide, mixed with a vortex shaker at a speed of 2500r / min for 40 seconds to make it evenly mixed, and dried in a vacuum Vacuum the dish for 60 seconds to remove air bubbles, pour it into a petri dish with a diameter of 3.5 cm, and then expose it to ultraviolet light with a wavelength of 365 nm for 60 seconds to form a polymer.

Embodiment 2

[0049] Example 2 Directly mixing PEG into the prepolymer for hydrophilic modification

[0050] Take mercapto 70+10% PEG as an example, wherein 10% PEG means that the weight of PEG accounts for 10% of the total weight of the prepolymer mixture (prepolymer and PEG), and the molecular weight of PEG used in the examples herein is 200.

[0051] The pre-preparation is similar to that of Example 1, except that 0.107 g of PEG is added to the prepolymer, and then mixed, vacuumed, and exposed.

[0052] In the test, it was found that the mixed PEG content is more than 20%, and the material is soft and difficult to tear off; in addition, when the PEG content is high, the transparency will become poor, and when the PEG content is 10%, the transparency and hydrophilicity of the material can be guaranteed. figure 2 Results are given for the effect of PEG content in the prepolymer on the hydrophilicity (contact angle) of the thiol-excess OSTE; image 3 Results are presented for the effect o...

Embodiment 3

[0053] Example 3 Using plasma to treat the surface of the material to further improve the hydrophilicity of the material

[0054] Taking the material prepared in Example 2 as an example, after ultraviolet exposure molding, put it into a plasma surface treatment machine to treat the surface of the material, and the treatment time is 3 minutes. Then put it into a vacuum drying dish and treat it with PEG vapor to evacuate, which can further enhance the hydrophilicity of the surface of the material.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
wavelengthaaaaaaaaaa
Login to View More

Abstract

The invention discloses a vinyl-thiol polymeric material used for preparing a micro-fluidic control chip. The material is obtained by polymerization utilizing a nonideal stoichiometric ratio. The invention in particular discloses a preparation method of the polymeric material and a method for carrying out internal structure modification and hydrophilic or hydrophobic surface modification on the material and further provides a method for preparing the micro-fluidic control chip by utilizing the polymeric material and the chip. The preparation method provided by the invention is short in reaction time and easily achieves batch preparation. The obtained material is simple and practicable in hydrophilic or hydrophobic surface modification method, has good stability after modification and has high practical value.

Description

technical field [0001] The invention relates to a microfluidic channel control chip and a vinyl-mercapto polymer material used for preparing the chip, in particular to the preparation of the microfluidic chip material, internal structure modification and surface hydrophilic / hydrophobic modification. Background technique [0002] At present, the detection of biological and chemical indicators usually requires the use of biosensors or electrochemical sensors. In order to realize the miniaturization of detection equipment and the miniaturization of sample samples, many sensors combine micro-channel control chip technology to realize the dispersion and mixing of samples. , amplification, detection and other functions. Polymers are the most commonly used materials for microfluidic control chips because of their low cost, easy processing, and easy surface modification. However, there are some problems when combining two or more layers of polymers in the microfluidic control chip:...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C08F126/06C08F2/48C08G81/02C08J7/12B01L3/00
Inventor 刘文佳苏文琼丁显廷
Owner SHANGHAI JIAO TONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com