Procalcitonin monoclonal antibody hybrid tumor 2H4 and monoclonal antibody
A technology of monoclonal antibody and clonal antibody, which is applied in the direction of anti-hormone immunoglobulin, anti-animal/human immunoglobulin, microorganisms, etc., can solve the problem of low serum PCT and achieve high specificity and sensitivity
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[0019] Embodiment 1 Preparation and identification of monoclonal antibody of the present invention
[0020] 1. Preparation of monoclonal antibody 2H4
[0021] 1) Design, preparation and carrier coupling of PCT antigen polypeptide
[0022] The human PCT protein sequence was obtained according to the human PCT sequence on GenBank (accession number: AGM62655.1), which contains 116 amino acids. Using TMHMM software to analyze the transmembrane domain of PCT protein, and IEDB software to analyze the immunogenicity, hydrophilicity and hydrophobicity and surface accessibility of PCT protein, the results show that human PCT protein 34-60aa has 27 amino acids antigenicity, hydrophilicity and surface accessibility stronger ( figure 1 ). After the above analysis, the final screening polypeptide sequence is: VQMKASELEQEQEREGSSLDSPRSKRC (34-60aa, SEQ ID NO: 2). The short peptide (PCT-P1) and the short peptide (PCT-P1-KLH) coupled to the keyhole limpet hemocyanin carrier protein KLH at ...
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