Drug sustained release magnesium alloy stent and preparation method thereof
A magnesium alloy stent and drug technology, applied in the field of medical devices, can solve the problems of unfavorable large-scale production, affecting the treatment effect, and negative effects on the human body, and achieve the effects of high market promotion value, increased service time, and easy preparation
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[0040] In addition, the present invention also provides a method for preparing a drug sustained-release magnesium alloy stent, which can be used to prepare the above-mentioned drug sustained-release magnesium alloy stent, comprising the following steps:
[0041] S100: The base of the laser-engraved magnesium alloy stent is dried 100°, polished, washed with water, then dipped in the first coating for 0.25-5 minutes, taken out and then dried and cured to obtain a magnesium alloy stent covered with the first coating. The first coating comprises silane coupling agent KH550, dehydrated alcohol and the first solvent, wherein, the first solvent is water, and the volume ratio of silane coupling agent KH550, dehydrated alcohol and water is 2~5:90~95: 3~6.
[0042] In the present invention, there are many ways to polish the magnesium alloy stent backbone 100, and electrochemical polishing is preferred.
[0043] In this step, the first coating 210 (ie, the coating of silane coupling age...
Embodiment 1
[0057] (1) Polish the base of the laser-engraved ZK60 magnesium alloy stent, wash it with water after polishing, then place it in the first coating and dip it for 0.25min, dry it at room temperature, put it in a drying oven, and sinter it at 120°C for 15min to obtain a surface coated with The magnesium alloy stent of the first coating; wherein, the volume ratio of each component in the first coating is: silane coupling agent KH550: absolute ethanol: water = 2:94:4, and the thickness of the first coating is 200nm;
[0058] (2) The surface of the magnesium alloy stent obtained in step (1) is ultrasonically sprayed with the second coating, then placed in a vacuum drying oven, dried in vacuum at 30°C for 12 hours, then heated to 80°C, and kept for 60 minutes to obtain a surface covered with the second coating. A coated magnesium alloy stent; wherein the second coating is composed of rapamycin, DL-PLCL and chloroform, and the sum of the mass of rapamycin and DL-PLCL is 0.5% of the t...
Embodiment 2
[0061] (1) Polish the base of the AE21 magnesium alloy stent that has been laser-engraved, wash it with water, then place it in the first coating for 2 minutes, dry it at room temperature, put it in a drying oven, and sinter it at 80°C for 60 minutes to obtain the surface coated with the first coating. A coated magnesium alloy stent; wherein, the volume ratio of each component in the first coating is: silane coupling agent KH550: absolute ethanol: water = 5:90:5, and the thickness of the first coating is 1 μm;
[0062](2) The surface of the magnesium alloy stent obtained in step (1) is ultrasonically sprayed with the second coating, then placed in a vacuum drying oven, dried in vacuum at 10°C for 24 hours, then heated to 50°C, and kept for 120min to obtain a surface covered with the second coating. A coated magnesium alloy stent; wherein the second coating is composed of paclitaxel, DL-PLCL and dichloromethane, and the sum of the mass of paclitaxel and DL-PLCL is 2% of the tota...
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Abstract
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