Natural slow-release multi-effect medical sponge and preparation method thereof

A slow-release, sponge technology, used in medical science, absorbent pads, bandages, etc., can solve the problems of excessive degradation rate, poor mechanical properties, limited application, etc., to achieve great application prospects, improve mechanical properties, and high carboxyl content. Effect

Inactive Publication Date: 2015-07-22
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, pure collagen sponge also has some defects: it is susceptible to bacterial erosion and deterioration in a humid environment; its mechanical properties are poor; its degradation rate is too fast, etc.
However, amylose molecules tend to associate in water and thus coagulate, and its water solubility is low, which limits its application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Weigh 30g of dry amylose, add 8mL of 30% hydrogen peroxide, 1mL of 1% copper sulfate aqueous solution, mix well, react at 75°C for 20min, add 200mL of deionized water to the reactant, React at ℃ for 20 min, precipitate with absolute ethanol, and freeze-dry to obtain oxidized amylose. Add 0.3 g of oxidized amylose to 1.5 mL of deionized water, heat to 55° C., quickly add 0.06 mL of anisole therein, and stir and react at room temperature for 15 min to obtain an inclusion compound solution. Dissolve 0.1 g of collagen with 0.05 mol / L acetic acid to make the mass concentration of collagen 0.6%, mix the clathrate solution with the collagen solution and stir at room temperature for 2 hours, freeze-dry the mixed solution to obtain a sponge product .

Embodiment 2

[0021] Weigh 30g of dry amylose, add 10mL of 30% hydrogen peroxide, 1.2mL of 1% copper sulfate aqueous solution, mix well, react at 70°C for 10~20min, add 300mL of deionized water to the reactant , reacted at 75°C for 30 minutes, precipitated with absolute ethanol, and freeze-dried to obtain oxidized amylose. Take 0.3g of oxidized amylose and add 2.5mL of deionized water, heat to 50°C, quickly add 0.05mL of linalool to it, stir and react at room temperature for 10min to obtain clathrate solution. Dissolve 0.1 g of collagen with 0.05 mol / L acetic acid to make the mass concentration of collagen 0.8%, mix the clathrate solution with the collagen solution and stir at room temperature for 3 hours, freeze-dry the mixed solution to obtain a sponge product .

Embodiment 3

[0023] Weigh 30g of dry amylose, add 10mL of 30% hydrogen peroxide, 1.3mL of 1% copper sulfate aqueous solution, mix well, react at 80°C for 10~20min, add 250mL of deionized water to the reactant , reacted at 70°C for 25 minutes, precipitated with absolute ethanol, and freeze-dried to obtain oxidized amylose. Take 0.3g of oxidized amylose and add 2mL of deionized water, heat to 55°C, quickly add 0.02mL of cinnamaldehyde to it, stir and react at room temperature for 8min to obtain clathrate solution. Dissolve 0.1 g of collagen with 0.05 mol / L acetic acid to make the mass concentration of collagen 1%, mix the clathrate solution with the collagen solution and stir at room temperature for 4 hours, freeze-dry the mixture to obtain a sponge product .

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PUM

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Abstract

The invention relates to natural slow-release multi-effect medical sponge and a preparation method thereof. The preparation method comprises the following steps: firstly, by taking hydrogen peroxide as an oxidant and copper sulfate as a catalyst, partially oxidizing straight-chain starch; adding a medicine to be slow-released into a water solution of the oxidized straight-chain starch in a mass ratio of 1:(2-100), and stirring at the room temperature so as to react to obtain a clathrate compound solution; dissolving collagen by using an acetum solution so as to obtain a collagen solution, subsequently mixing the clathrate compound solution with the collagen solution, and performing freeze-drying, thereby obtaining the natural slow-release multi-effect medical sponge. Collagen is used as the basis material of the medical sponge and has better hydrophily, biocompatibility and biocompatibility. The natural slow-release multi-effect medical sponge provided by the invention has various bioactivities, has the characteristics of slow-release and temperature control release, and has good application prospect in the medicinal industry.

Description

technical field [0001] The invention relates to the technical field of medical sponge processing, in particular to a natural slow-release multi-effect medical sponge with good hydrophilicity, biocompatibility and environmental degradability and a preparation method thereof. Background technique [0002] There are many kinds of existing medical sponges, which can be classified into synthetic and biological according to the material of the sponge. Using polymer materials, various forms of sponges can be obtained through different preparation processes. Polyurethane, polylactic acid and polyvinyl alcohol are the most well-developed materials in synthetic polymer sponges. [0003] The material sources of biological sponges that are currently studied mainly include collagen, chitin and its derivatives, and alginate. Natural biopolymer materials have the characteristics of degradability, and different materials have their unique biological activities, which is an important tren...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/32A61L15/44A61L15/42
Inventor 穆畅道周颖葛黎明李德富吕永博曾钰
Owner SICHUAN UNIV
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