Drugs for improving toxic and side effects of tumor chemotherapy

A technology of toxic and side effects and drugs, applied in anti-tumor drugs, drug combinations, anti-toxic agents, etc., can solve problems such as shortening of survival, life-threatening, infection, etc., to reduce adverse reactions, improve toxic and side effects, and improve the quality of life Effect

Inactive Publication Date: 2016-02-03
QINGDAO CENT HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the toxic and side effects of chemical drugs can seriously affect the patient's mental and physical strength, gastrointestinal reactions, loss of appetite, etc., if not corrected in time, the patient's immunity will be weakened, the leukocytes will be reduced, leading to serious infection, even life-threatening. Make patients lose confidence in treatment, thus affecting the quality of life of patients and reducing the survival period

Method used

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  • Drugs for improving toxic and side effects of tumor chemotherapy

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preparation example Construction

[0050] The present invention also provides the preparation method of above-mentioned medicine, specifically:

[0051] The first step, take psoraleae by weight and pulverize it, pass through a 40 mesh sieve, and carry out CO 2 Supercritical extraction, extraction pressure 27MPa, extraction temperature 70°C, CO 2 The flow rate is 4.5-5L / h, the extraction time is 3h, and the extract in the form of extract is obtained, which is adsorbed by silica gel with a particle size of 200-300 mesh, eluted with petroleum ether, the eluate is collected, petroleum ether is recovered, and psoraleae extract is obtained ;

[0052] The second step is to weigh astragalus, ginseng, gorgon, ryepogon, sealwort, salvia, spatholobus, morinda officinalis, cardamom, winter lily, Baogai grass, Dijin grass and Guan Phellodendron by weight, and crush them separately , cross a 40-mesh sieve, mix well, and reflux extract 3 times with ethanol with an alcohol concentration of 60% to 80% relative to the mass of ...

Embodiment 1

[0060] Embodiment 1 Powder 1

[0061] Weigh 25 g of psoraleae, pulverize, pass through a 40 mesh sieve, and carry out CO 2 Supercritical extraction, extraction pressure 27MPa, extraction temperature 70°C, CO 2 The flow rate is 5L / h, the extraction time is 3h, and the extract in the form of extract is obtained, which is adsorbed by silica gel with a particle size of 200 mesh, eluted with petroleum ether, the eluate is collected, the petroleum ether is recovered, and the extract of psoraleae is obtained, and the Astragalus membranaceus is weighed 60g, 40g ginseng, 25g Gorgon, 25g Liedong, 30g Polygonatum, 40g Salvia, 30g Caulis Spatholobus, 25g Morinda officinalis, 30g Cardamom, 20g Donglima, 25g Baogaicao, 25g Dijincao and Guanhuangbai 30g, respectively pulverized, passed through a 40-mesh sieve, mixed evenly, extracted 3 times with 2.5kg of ethanol with an alcohol concentration of 80%, 2 hours each time, combined the extracts, and filtered; the filtrate was adjusted to pH6 wi...

Embodiment 2

[0064] Embodiment 2 Powder 2

[0065] Take psoraleae 23g and pulverize, pass through a 40-mesh sieve, and carry out CO 2 Supercritical extraction, extraction pressure 27MPa, extraction temperature 70°C, CO 2 The flow rate is 5L / h, the extraction time is 3h, and the extract in the form of extract is obtained, which is adsorbed by silica gel with a particle size of 200 mesh, eluted with petroleum ether, the eluate is collected, the petroleum ether is recovered, and the extract of psoraleae is obtained, and the Astragalus membranaceus is weighed 58g, 38g ginseng, 23g Gorgon, 23g Liedong, 28g Polygonatum, 38g Salvia, 28g Caulis Spatholobus, 23g Morinda officinalis, 28g cardamom, 18g Donglima, 23g Baogaicao, 23g Dijincao and Guan Phellodendron 28g, respectively pulverized, passed through a 40-mesh sieve, mixed evenly, extracted 3 times with 2.5kg of ethanol with an alcohol concentration of 80%, 2 hours each time, combined the extracts, and filtered; the filtrate was adjusted to pH...

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Abstract

The invention provides a drug for improving toxic or side effects caused after tumor chemotherapy. The drug comprises the following raw materials: astragalus mongholicus, ginseng, semen euryales, cattail pollen, fructus psoraleae, poria cocos, radix liriopes, rhizoma polygonati, radix salviae miltiorrhizae, lignum millettiae, herba hedyotis, rhizoma polygoni cuspidati, radix morindae officinalis, alpinia katsumadai, coix lachrymajobi L., aster ageratoides, debregeasia orientalis C. J. Chen, henbit, filifoliumsibiricum, lawn pennywort herb, humifuse euphorbia herb and cortex phellodendri amurensis. The drug is combined with chemotherapy to treat tumor, improves the survival quality of a tumor patient, effectively reduces the adverse effects caused by chemotherapy, has no adverse effects after being taken, and is rich in drug source, economical and worthy of popularization.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a medicine for improving toxic and side effects of tumor chemotherapy. Background technique [0002] Malignant tumors are common and frequently occurring diseases that seriously threaten human health, and are one of the diseases that cause the greatest mental stress. Since most patients are already in the middle or late stage when they go to the doctor, chemical drug treatment is often required. However, the toxic and side effects of chemical drugs can seriously affect the patient's mental and physical strength, gastrointestinal reactions, loss of appetite, etc., if not corrected in time, the patient's immunity will be weakened, the leukocytes will be reduced, leading to serious infection, even life-threatening The patient loses confidence in the treatment, thus affecting the quality of life of the patient and reducing the survival period. How to improve th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9062A61P35/00A61P39/00A61P1/14A61P37/04A61P7/00
Inventor 鞠芳王志海杜国威李萌
Owner QINGDAO CENT HOSPITAL
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