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Application of cappariloside A in the preparation of medicines for treating influenza and influenza virus-mediated inflammatory diseases

A technology of influenza virus and medicine, which is applied in the field of medicine, can solve the problems that the application of CapparilosideA has not been reported, and achieve the effect of less toxic and side effects

Active Publication Date: 2019-05-10
THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT) +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There have been reports on the chemical separation and structural identification of Cappariloside A (mouse citrurin A) (eg Phytochemistry, 1999, 50:1205-1208), but the anti-influenza virus and inhibition of influenza virus-mediated inflammatory factors of Cappariloside A The application in production has not been reported

Method used

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  • Application of cappariloside A in the preparation of medicines for treating influenza and influenza virus-mediated inflammatory diseases
  • Application of cappariloside A in the preparation of medicines for treating influenza and influenza virus-mediated inflammatory diseases
  • Application of cappariloside A in the preparation of medicines for treating influenza and influenza virus-mediated inflammatory diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Separation, purification and structural identification of cappariloside A monomer components

[0021] Adopt the existing separation and purification method of this technical field to separate and purify Cappariloside A, and its separation and purification method is introduced as follows for reference below: Radix isatidis methanol extract is dissolved in water, extracted with ethyl acetate and n-butanol respectively, and n-butanol The alcohol part was further desugared by macroporous resin D101, and the ethanol eluted part was collected and separated by Sephadex LH-20 column chromatography, and Fr.1~Fr was obtained by methanol-water (0:100-100:0, volume ratio) gradient elution .6. Fr.3 was further purified by preparative HPLC to obtain white powder-like crystals.

[0022] The crystallization is analyzed by NMR and ESI-MS spectrum, and the results are as follows:

[0023] ESIMS m / z:357.1058[M+Na] + (calcd for C 16 h 18 N 2 o 6 :334.1058).1H-NMR(DMSO-d6...

Embodiment 2

[0024] The chemical synthesis of embodiment 2 Cappariloside A

[0025] A kind of method of synthesizing Cappariloside A is provided below for reference, prepare Cappariloside A according to the following steps (the percentages appearing in this embodiment are all mass percentages if not specified otherwise):

[0026] 1) Preparation of N,N-dimethyl(4-benzyloxy-1H-indol-3-yl)methanamine (corresponding to figure 1 Compound 2)

[0027]Add 1,4-dioxane (100mL), glacial acetic acid (100mL) and 37% formaldehyde hydrate (3.83mL, 50.5mmol) into a 1000mL round bottom flask, and add 40% dimethylamine dropwise at 0°C The solution of aqueous solution and 4-benzyloxyindole in 1,4-dioxane (11.16g dissolved in 100mL 1,4-dioxane), after the dropwise addition, was raised to room temperature and stirred for 36 hours. Add 500mL of water to the reaction solution, adjust the pH value to between 8-9 with 10% aqueous sodium hydroxide solution, filter the precipitated white precipitate, wash the fi...

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Abstract

The invention provides application of Cappariloside A in preparation of medicine for treating influenzas and influenza virus mediated inflammatory diseases and provides a novel way to clinically treat influenza virus caused diseases. The Cappariloside A has the effects of suppressing replication of progeny viruses of influenza viruses and suppressing occurrence of influenza virus mediated inflammatory factors. The invention further provides the medicine for treating the influenzas or influenza virus mediated inflammations; active components of the medicine include the Cappariloside A mentioned above. The Cappariloside A has the effects of safety, effectiveness and low toxic and side effects on treating the influenza virus caused diseases.

Description

technical field [0001] The invention belongs to the technical field of medicine, and further relates to the application of Cappariloside A in the preparation of anti-influenza virus drugs and the preparation of drugs for treating influenza virus-mediated inflammatory diseases. Background technique [0002] After the influenza virus infects the human body, in addition to the damage caused by the virus itself, the virus can also cause the host's immune response, release a large number of inflammatory cells and inflammatory factors, cause an inflammatory storm, and further aggravate the host's damage. Studies have shown that the level of inflammatory factors in the blood increases significantly after influenza virus infects humans, especially after humans are infected with avian influenza virus. Dysregulation of inflammatory cytokines is associated with disease severity and clinical outcomes caused by influenza virus. Studies have also shown that dysregulation of inflammatory ...

Claims

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Application Information

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IPC IPC(8): A61K31/7056A61P31/16
Inventor 杨子峰李征途李菁钟南山李楚源胡文辉王德勤赵军岭
Owner THE FIRST AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIV (GUANGZHOU RESPIRATORY CENT)
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