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A kind of nanocomposite skin antiseptic emulsion and preparation method thereof

A skin disinfection and nano-composite technology, which is applied in emulsion delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems such as weak sterilization ability, cross-infection, and large irritation of skin and mucous membranes, and achieve safety in use Good, increased stability, good appearance effect

Active Publication Date: 2019-10-11
INST OF PLA FOR DISEASE CONTROL & PREVENTION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] There are many types of skin and mucous membrane disinfectants commonly used at present, but they all have more or less defects, such as quaternary ammonium salts with narrow antibacterial spectrum and weak bactericidal ability; ethanol is highly irritating to skin and mucous membranes; iodophor has a short duration of bactericidal effect; Chlorhexidine acetate is prone to produce drug-resistant strains
It is difficult for traditional disinfectants to fully meet the needs of hand disinfection of medical staff in various clinical departments, resulting in cross-infection

Method used

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  • A kind of nanocomposite skin antiseptic emulsion and preparation method thereof
  • A kind of nanocomposite skin antiseptic emulsion and preparation method thereof
  • A kind of nanocomposite skin antiseptic emulsion and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0054] Embodiment 1, preparation nanocomposite skin antiseptic emulsion

[0055] Prepare the nanocomposite skin antiseptic emulsion according to the following steps:

[0056] Add 0.1 g of double decyl dimethyl ammonium chloride into a beaker filled with 40-60 mL of distilled water, and stir with a stirrer until it is completely dissolved. Slowly add 30mL of aloe vera extract into the didecyldimethylammonium chloride solution, stirring while adding. Pipette 10mL of complex emulsifier (containing 2mL of tri-n-butyl phosphate, 404mL of Span, and 804mL of Tween) into the above mixed solution, and stir evenly. Weigh 0.05g of nano-zinc oxide with a particle size of 50-100nm in proportion, add it to the mixed solution, add distilled water to make up the solution to 100mL, and stir it evenly with a stirrer. ), emulsified under 25Mpa working pressure to form a milky white opaque emulsion.

[0057] In the present embodiment, the final concentration of each component in the disinfecta...

Embodiment 2

[0058] Embodiment 2, preparation nanocomposite skin antiseptic emulsion

[0059] Prepare the nanocomposite skin antiseptic emulsion according to the following steps:

[0060] Add 0.2g of didecyldimethylammonium bromide into a beaker filled with 40-60mL of distilled water, and stir with a stirrer until completely dissolved. Slowly add 20mL of aloe vera extract into the didecyldimethylammonium bromide solution, stirring while adding. Pipette 20mL of compound emulsifier (including 4mL of tri-n-butyl phosphate, 408mL of Span, and 808mL of Tween) into the above mixed solution, and stir evenly. Weigh 0.05g of nano-zinc oxide with a particle size of 50-100nm in proportion, add it to the mixed solution, add distilled water to make up the solution to 100mL, and stir it evenly with a stirrer. ), emulsified under 35Mpa working pressure to form a milky white opaque emulsion.

[0061] In the present embodiment, the final concentration of each component in the disinfectant emulsion prepa...

Embodiment 3

[0062] Embodiment 3, preparation nanocomposite skin antiseptic emulsion

[0063] Add 0.5 g of bis(dodecyldimethyl)ethylene diammonium bromide into a beaker filled with 40-60 mL of distilled water, and stir with a stirrer until completely dissolved. Slowly add 20 mL of aloe extract into the bis(dodecyldimethyl)ethylene diammonium bromide solution, and stir while adding. Pipette 10mL of complex emulsifier (containing 2mL of tri-n-butyl phosphate, 404mL of Span, and 804mL of Tween) into the above mixed solution, and stir evenly. Weigh 0.01g of nano-zinc oxide with a particle size of 50-100nm in proportion, add it to the mixed solution, add distilled water to make up the solution to 100mL, and stir it evenly with a stirrer. ), emulsified under 30Mpa working pressure to form a milky white opaque emulsion.

[0064] In the present embodiment, the final concentration of each component in the disinfectant emulsion prepared by the above-mentioned ingredients and method is: bis(dodecyl...

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Abstract

The invention discloses a nano composite skin disinfection emulsion and a preparation method of the same. The nano composite skin disinfection emulsion is composed of a double-chain quaternary ammonium salt compound, an inorganic nano antibacterial substance, an emulsifier, aloe extract liquid and water, wherein the double-chain quaternary ammonium salt compound is didecyldimethylammonium bromide, didecyldimethylammonium chloride or bis(dodecyldimethyl)ethylene diammonium bromide, and the inorganic nano antibacterial substance is nano zinc oxide, nano silver oxide or nano titanium oxide, and the aloe extract liquid is raw liquid from aloe. The emulsion, when acting on staphylococcus aureus, escherichia coli and candida albicans for 1 min, can reach 100% in killing ratio all. The emulsion is high in inhibiting rates of 6 h, 12 h, 24 h and 48 h on natural bacteria. When acting on hands of a subject for 1 min, the emulsion is higher than 90% in average killing rate on natural bacteria. The emulsion is excellent in stability, can be safely used on human skin and mucosa, and is free of damage and stimulation on environment and human body.

Description

technical field [0001] The invention relates to a disinfecting emulsion and a preparation method thereof, in particular to a nanocomposite skin disinfecting emulsion and a preparation method thereof. Background technique [0002] Skin and mucous membranes are the body's effective barriers against microbial infiltration of tissues, but microorganisms are abundant on their surfaces. In daily life, through the disinfection of hands and skin and mucous membranes, intestinal infectious diseases, skin suppuration, and genitourinary system infections can be prevented; Infection is one of the most important and easiest measures. [0003] There are many types of skin and mucous membrane disinfectants commonly used at present, but they all have more or less defects, such as quaternary ammonium salts with narrow antibacterial spectrum and weak bactericidal ability; ethanol is highly irritating to skin and mucous membranes; iodophor has a short duration of bactericidal effect; Chlorhe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/14A61K36/886A61K36/896A61K9/107A61P31/02A61P31/04A61P31/10A61K33/24A61K33/30A61K33/38
CPCY02A50/30
Inventor 魏秋华张文福武雪冰袁国刚饶林韩杰
Owner INST OF PLA FOR DISEASE CONTROL & PREVENTION