Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of temperature and pH sensitive organic/inorganic hybrid material POSS/PDMAEMA-b-PNIPAM

A hybrid material and sensitive technology, applied in the field of chemical industry and new materials, can solve the problems of poor product dispersion, complicated preparation process, and low monomer selectivity, and achieve high production yield, no pollution to the environment, and stereoselectivity strong effect

Inactive Publication Date: 2015-08-12
TONGJI UNIV
View PDF5 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And these preparation methods all have certain deficiencies, such as less monomer selectivity, slow polymerization rate, poor product dispersibility, complicated preparation process, low yield and high cost.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of temperature and pH sensitive organic/inorganic hybrid material POSS/PDMAEMA-b-PNIPAM
  • Preparation method of temperature and pH sensitive organic/inorganic hybrid material POSS/PDMAEMA-b-PNIPAM
  • Preparation method of temperature and pH sensitive organic/inorganic hybrid material POSS/PDMAEMA-b-PNIPAM

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028]The first step of synthesis: take 5.56 g of dimethylaminoethyl methacrylate monomer in a 25 mL single-necked round bottom flask. Take 100 mg of 4-cyano-4-(thiobenzoyl)valeric acid and 20.42 mg of azobisisobutyronitrile powder in a 50 mL beaker, add 10 mL of dioxane to dissolve. Then the two were mixed, and the one-necked flask was evacuated at 0°C through the "T-shaped" tee, and nitrogen gas was introduced. Under the protection of nitrogen, it was placed in an oil bath at 90 °C for 12 h, and stirred uniformly by magnetic force. After the reaction was completed, the flask was cooled to room temperature and vented to the atmosphere, and the cooled solution was rotated at 45° C. to remove the solvent. Dissolve the sample in 10 mL of dichloromethane, add it dropwise to 300 mL of ice petroleum ether, let it stand for 4 hours, remove the upper liquid, and obtain a viscous sample at the bottom. The above steps were repeated twice, and finally the samples were vacuum-dried at ...

Embodiment 2

[0034] Same as Example 1, but the amount of dimethylaminoethyl methacrylate in the first step of synthesis becomes 19.46g, and the monomer (dimethylaminoethyl methacrylate) and chain transfer agent (4-cyano) in the system -4-(thiobenzoyl)valeric acid) and initiator (azobisisobutyronitrile) molar ratio was changed to 350:1:0.3.

Embodiment 3

[0036] Same as Example 1, but the amount of dimethylaminoethyl methacrylate in the first step of synthesis is changed to 11.12g, and the monomer (dimethylaminoethyl methacrylate) and chain transfer agent (4-cyano) in the system -4-(thiobenzoyl)valeric acid) and the initiator (azobisisobutyronitrile) in a molar ratio of 200:1:0.3.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a preparation method of a temperature and pH sensitive organic / inorganic hybrid material POSS / PDMAEMA-b-PNIPAM. The method comprises the following steps: synthesizing PDMAEMA-CTA through adopting a reversible addition-fragmentation chain transfer polymerization technology; synthesizing a diblock polymer PDMAEMA-b-PNIPAM by adopting an RAFT polymerization technology with PDMAEMA-CTA as a macromolecular chain transfer agent and N-isopropylacrylamide as a monomer; and carrying out a thiol-ene click chemical reaction on the PDMAEMA-b-PNIPAM and vinyl POSS to generate the temperature and pH sensitive organic / inorganic hybrid material POSS / PNIPAM-b-PDMAEMA. In an aqueous solution, the POSS / PNIPAM-b-PDMAEMA self-assembles with the change of the temperature and the pH value to form micelle. The method has the characteristics of simplicity, convenience, high preparation yield and no pollution to environment, and the hybrid material can be applied to medicinal fields of organic dye adsorption, heavy metal adsorption and in vivo delivery of insoluble anticancer medicines.

Description

technical field [0001] The invention belongs to the technical field of chemical engineering and new materials, in particular to a method for preparing an organic / inorganic hybrid material POSS / PDMAEMA-b-PNIPAM with temperature and pH sensitivity. Background technique [0002] Environmentally responsive materials can respond to external stimuli in a timely manner, and are a class of smart materials that have attracted much attention. Environmentally responsive amphiphilic polymer materials can self-assemble into aggregates of various shapes such as micelles and vesicles in selective solvents. These aggregates can not only respond to external temperature, pH, salt and other stimuli In response to the source, organic dyes and drugs that are poorly soluble in water can also be loaded into the hydrophobic segment, so it has application value in the fields of environment and biomedicine. Compared with pure polymer environmental responsive materials, environmentally responsive org...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C08F293/00C08F8/42
Inventor 杨正龙刘芯岩
Owner TONGJI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com