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Preparation method for degradable polylactic acid-glycolic acid/polycaprolactone/I-type collagen electrospun fiber membrane material

A technology of glycolic acid and polycaprolactone, which is applied in the direction of cellulose/protein conjugated artificial filaments, textiles and papermaking, conjugated synthetic polymer artificial filaments, etc. Biological activity and other issues, to achieve the effect of short degradation cycle, improved repair effect, and simple operation

Inactive Publication Date: 2015-08-12
RES INST OF SOUTHEAST UNIV IN SUZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional degradable polymer materials do not have specific biological activity. Therefore, active ingredients with specific biological functions are added to degradable polymer materials to enable them to perform corresponding biological functions; Materials cannot effectively guide the newborn tissue. Therefore, the preparation has specific biological activity and can guide tissue regeneration, which will further serve the biomedical field

Method used

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  • Preparation method for degradable polylactic acid-glycolic acid/polycaprolactone/I-type collagen electrospun fiber membrane material
  • Preparation method for degradable polylactic acid-glycolic acid/polycaprolactone/I-type collagen electrospun fiber membrane material
  • Preparation method for degradable polylactic acid-glycolic acid/polycaprolactone/I-type collagen electrospun fiber membrane material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Cut polylactic acid-glycolic acid and polycaprolactone with a number average molecular weight of 110,000 into pieces, dissolve them in trifluoroethanol at a mass ratio of 1:1, and prepare a solution with a mass fraction of 8%, and then pour into the solution Add 0.5ml of 5mg / ml type I collagen solution, mix well, add the solution into the glass syringe, extrude through the propulsion device, the supply volume is 0.8mL / h, the electrospinning voltage is 15kV, the distance is 20cm, and the rotating cylinder The receiving device was set at a rotating speed of 3000rpm, and received continuously for 10 hours to obtain a 0.4mm thick electrospun fiber membrane with an average fiber diameter of 560nm and an electrospun fiber orientation rate of about 70%.

[0030] Scanning electron micrographs of the fibrous membrane as figure 1 shown.

Embodiment 2

[0032] Shred polylactic acid-glycolic acid and polycaprolactone with a number average molecular weight of 110,000, dissolve them in trifluoroethanol at a mass ratio of 1:1, prepare a solution with a mass fraction of 12%, and then add 1ml of 5mg / ml type I collagen solution, after fully mixing, add the solution into the glass syringe, extrude through the propulsion device, the supply volume is 0.5mL / h, the electrospinning voltage is 15kV, the receiving distance is 20cm, and the drum receives The rotation speed of the device was set at 2400rpm, and the receiving was continued for 7 hours. Finally, a layer of electrospun fiber membrane with a thickness of about 0.45mm was obtained, the average fiber diameter was 600nm, and the orientation rate of the electrospun fiber was about 75%. Put it in a vacuum drying oven for 48 hours, detect its spectral distribution with an infrared spectrometer, and compare it with the electrospun membrane of polylactic acid-glycolic acid / polycaprolacton...

Embodiment 3

[0035] Shred polylactic acid-glycolic acid and polycaprolactone with a number average molecular weight of 110,000, dissolve them in trifluoroethanol at a mass ratio of 1:1, prepare a solution with a mass fraction of 15%, and then add 1ml of 5mg / ml type I collagen solution, after fully mixing, add the solution into the glass syringe, extrude through the propulsion device, the supply volume is 0.4mL / h, the electrospinning voltage is 15kV, the receiving distance is 20cm, and the rotating cylinder receives The rotation speed of the device was set at 2100rpm, and the receiving was continued for 5 hours. Finally, a layer of electrospun fiber membrane with a thickness of about 0.4mm was obtained, the average fiber diameter was 860nm, and the orientation rate of the electrospun fiber was about 80%. Mouse adipose stem cells were inoculated on the surface of the material.

[0036] attached image 3It is a polylactic acid-glycolic acid / polycaprolactone / type I collagen electrospun fiber ...

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Abstract

The invention discloses a preparation method for degradable polylactic acid-glycolic acid / polycaprolactone / I-type collagen electrospun fiber membrane material. The preparation steps comprise that 1) polylactic acid-glycolic acid and polycaprolactone are cut into pieces to be added to a solvent to form a uniform solution, an I-type collagen solution is added, and the solution is fully mixed through stirring so that a spinning solution is obtained; and 2) the electrospun fiber membrane material is prepared by the spinning solution through a directional electrospinning method. The electrospun fiber membrane material is great in fiber direction uniformity, great in mechanical strength and adjustable and controllable in fiber diameter and has biological activity, and the prepared material is short in degradation period. The preparation method is easy to operate and low in cost.

Description

technical field [0001] The invention belongs to the field of preparation of directional electrospun fiber membranes, in particular to a preparation method of a degradable polylactic acid-glycolic acid / polycaprolactone / type I collagen electrospun fiber membrane material. Background technique [0002] Electrospinning is a common technique for processing and preparing fibers. This method can prepare fibers with a fiber diameter of several nanometers to tens of microns. The stacking of these fibers can form a non-woven fabric with a large specific surface area. The principle of this technical method is described as follows: the polymer is prepared into a polymer solution, the solution is added to the storage device, and slowly extruded through the propulsion device; a high voltage of several thousand to tens of thousands of volts is applied at the discharge port, The high voltage has two functions: to make the polymer solution or melt surface with a large amount of charge, and s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D04H1/728D04H1/4382D01F8/14D01F8/02
Inventor 章非敏陈汉帮夏阳陈刚
Owner RES INST OF SOUTHEAST UNIV IN SUZHOU
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