Method and application for rapidly detecting mother chrysanthemum medicinal materials by utilizing near infrared spectroscopy

A near-infrared spectroscopy and near-infrared spectroscopy technology, which is applied in the direction of material analysis, measuring devices, and analysis materials through optical means, can solve the problems of single, time-consuming, and labor-intensive quality indicators of medicinal materials, and achieve simple operation and accuracy High quality and safe effect

Inactive Publication Date: 2015-08-12
CHINA RESOURCES SANJIU MEDICAL & PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For this reason, what the present invention is to solve is the technical problem that the existing wild chrysanthemum medicinal material quality detection method is time-consuming, laborious and has a single index for controlling the quality of medicinal material, thereby providing a method of utilizing near-infrared spectroscopy to quickly detect the content and concentration of chrysanthemum in the wild chrysanthemum. The method for moisture content, and then provide the application of the above method in the field of wild chrysanthemum medicinal material quality detection and control, and control its quality from the source of production of wild chrysanthemum preparations (such as: Chinese patent medicine Ganmaoling granules), thereby ensuring the safety of the final product quality , stability and effectiveness, to achieve the purpose of fast and efficient quality control

Method used

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  • Method and application for rapidly detecting mother chrysanthemum medicinal materials by utilizing near infrared spectroscopy
  • Method and application for rapidly detecting mother chrysanthemum medicinal materials by utilizing near infrared spectroscopy
  • Method and application for rapidly detecting mother chrysanthemum medicinal materials by utilizing near infrared spectroscopy

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Embodiment 1

[0044] Example 1 Determination of the content of chrysanthemum glucoside in the wild chrysanthemum medicinal material by near-infrared spectrometry

[0045] The present embodiment Menghuaside assay comprises the following steps:

[0046] (1) Select 45 batches of wild chrysanthemum medicinal materials whose content of chrysanthemum glycosides is known, and pass through an 80-mesh sieve after crushing to obtain said wild chrysanthemum medicinal material powder.

[0047] Take about 0.25g of wild chrysanthemum medicinal material powder, add 50mL of 70% methanol into a stoppered Erlenmeyer flask, ultrasonicate for 1.5h, cool to room temperature, and extract for later use.

[0048] The extract sample was filtered with a 0.45 μm filter membrane and injected into HPLC for analysis. The chromatographic conditions are: the mobile phase is 0.5% phosphoric acid aqueous solution and acetonitrile (V / V 70:30), the chromatographic column is Agilent Zorbax SB-C18 (4.6*250mm, 5μm), the column ...

Embodiment 2

[0073] Example 2 Determination of the moisture content of the wild chrysanthemum medicinal material by near-infrared spectroscopy

[0074] The present embodiment moisture content determination comprises the following steps:

[0075] (1) Select 45 batches of wild chrysanthemum medicinal materials whose content of chrysanthemum glycosides is known, and pass through an 80-mesh sieve after crushing to obtain said wild chrysanthemum medicinal material powder.

[0076] Adopt drying method to measure the moisture content in described wild chrysanthemum medicinal material as standard content. Take 2-5g of wild chrysanthemum medicinal material powder and place it in a weighing bottle dried to constant weight, dry at 105°C for 6h, move to a desiccator to cool for 30min, accurately weigh, then dry at the above temperature for one hour, cool down, and weigh Weight, until the difference between two consecutive times does not exceed 5mg, calculate the moisture content.

[0077] (2) Carry ...

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Abstract

The invention belongs to the technical field of medicinal material detection and in particular relates to a method and application for rapidly detecting mother chrysanthemum medicinal materials by utilizing a near infrared spectroscopy. The method comprises the steps of measuring the content of linarin and / or measuring the content of moisture, namely (1) selecting the mother chrysanthemum medicinal materials with the known content, grinding, and screening, thereby obtaining medicinal material powder; (2) collecting the near infrared spectroscopy of the mother chrysanthemum medicinal materials; (3) selecting spectral information under characteristic wave bands of 4597.6-7501.9cm<-1> and 4700-6800cm<-1>, associating with the known content of the linarin and content of the moisture of the mother chrysanthemum medicinal materials, and establishing a quantitative calibration model between the near infrared spectroscopy and the standard content; and (4) performing near infrared spectroscopy scanning on an unknown sample, selecting spectral information under the characteristic wave bands, and importing the established quantitative calibration model, thereby obtaining the contents of the linarin and the moisture of the unknown sample. According to the method, the mother chrysanthemum medicinal materials are rapidly and comprehensively detected, the method has the advantages of being easy to operate, high in accuracy, high in precision and the like, and the quality of a mother chrysanthemum preparation is safe and effective.

Description

technical field [0001] The invention belongs to the technical field of medicinal material detection, and in particular relates to a method and application for rapidly detecting wild chrysanthemum medicinal materials by using near-infrared spectroscopy. Background technique [0002] Wild chrysanthemum is the dry flower head of wild chrysanthemum in Compositae. It tastes bitter, pungent, and slightly cold in nature. Wild chrysanthemum has the effects of anti-pathogenic microorganisms, treating cardiovascular system diseases, lowering blood pressure, reducing platelet aggregation, anti-inflammation, immunity, and anti-oxidation. In addition, it is also used to treat tumors, hypertension, and hyperlipidemia. Epidemic meningitis also has a certain preventive effect. [0003] Due to the complex chemical composition of wild chrysanthemum medicinal materials, and factors such as variety, source, place of origin, and growth years will affect the quality of wild chrysanthemum medicin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/359G01N21/3563
Inventor 张跃飞杨凯陈周全邓海欣林丽娜马鹏岗马舒冰
Owner CHINA RESOURCES SANJIU MEDICAL & PHARMA
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