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Hydroxypropyl starch copolymer for hollow capsules and preparation method of capsules taking hydroxypropyl starch copolymer as raw material

A technology of hydroxypropyl starch and hollow capsules is applied in the directions of capsule delivery, medical preparations with non-active ingredients, pharmaceutical formulations, etc., which can solve the problems of application limitation, glue liquid layering, affecting product quality, etc., and reduce the preparation cost. , Improve quality, solve the effect of high production cost

Active Publication Date: 2015-09-09
SHANDONG RUIYUAN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, starch also has many defects: insoluble in cold water, unstable viscosity of starch paste, etc., which greatly limits its application
However, a single hydroxypropyl starch hollow capsule has disadvantages such as brittle membrane and high damage rate, which limits its large-scale application in the preparation of hollow capsules.
Cellulose ethers such as hypromellose and hydroxyethyl cellulose are water-soluble polyhydroxy polymer compounds commonly used in the field of food and pharmaceutical excipients. They have good film-forming properties and flexibility, and are also used in the manufacture of hollow capsules , such as "vegetable gum for preparing hollow capsules and its hollow capsules" (CN103933011), "a production method of starch hollow capsules" (CN103830736) and other inventions all use the blending system of cellulose ether and starch, but the fiber Vegetarian ether and hydroxypropyl starch solution are thermodynamically incompatible systems, simple blending can easily cause instability such as glue layering, which seriously affects product quality

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A hydroxypropyl starch copolymer hollow capsule and a preparation method thereof, the preparation steps are as follows: first, 50 kg of hydroxypropyl starch is added to 120 kg of water containing 5 kg of disodium hydrogen phosphate and 20 kg of sodium dihydrogen phosphate to adjust the pH value to 5.5 at 55°C Stir and heat to react for 1 hour, add 10 kg of hypromellose and 0.1 kg of sodium hexametaphosphate, adjust the pH to 9, and stir for 3 hours at 55°C. After the reaction finishes, cool to room temperature, concentrate to 90kg, add 180kg of ethanol, fully stir, make the copolymer precipitate, obtain 58kg of hydroxypropyl starch copolymer after filtering, washing and drying precipitate. Add 15% by weight of hydroxypropyl starch copolymer, 1% xanthan gum, and 5% glycerin into water, stir and heat at 50°C for 2 hours to completely dissolve and clarify the system to obtain glue; solvent decompression or centrifugation soaked, kept at 45°C, the template for preparing cap...

Embodiment 2

[0033] A hydroxypropyl starch copolymer hollow capsule and a preparation method thereof, the preparation steps are as follows: first, add 10 kg of hydroxypropyl starch into 40 kg of water, slowly add 0.8 kg of acetic anhydride, maintain a pH value of 8, and heat to 35 ° C with stirring After reacting for 2 hours, add 3 kg of hypromellose and 0.1 kg of epichlorohydrin, adjust the pH to 10, and react with stirring at 50° C. for 2 hours. After the reaction was finished, cool to room temperature, concentrate to 30kg, add 60kg of ethanol, fully stir to make the copolymer precipitate, filter, wash and dry the precipitate to obtain 12.5kg of hydroxypropyl starch copolymer. Add 15% by weight hydroxypropyl starch copolymer, 1% carrageenan, and 4% glycerin to water, stir and heat at 50°C for 2 hours to completely dissolve and clarify the system to obtain glue; depressurize the solvent or centrifuge to defoam , kept at 50 °C, the template for preparing capsules was immersed in the feed l...

Embodiment 3

[0035] A hydroxypropyl starch copolymer hollow capsule and a preparation method thereof, the preparation steps are as follows: first, 30 kg of hydroxypropyl starch is added to 90 kg of water containing 3 kg of octenyl succinic anhydride, stirred and heated at 35° C. for 10 hours, and then 6 kg of Hydroxyethyl cellulose, 0.1kg sodium hexametaphosphate, adjust the pH to 9, and stir at 55°C for 3 hours. After the reaction was finished, cool to room temperature, filter, concentrate the supernatant to 90kg, add 200kg of methanol, stir fully, make the copolymer precipitate, filter, wash and dry the precipitate to obtain 35kg of hydroxypropyl starch copolymer. Add 25% by weight hydroxypropyl starch copolymer, 1% carrageenan, and 5% ethylene glycol into water, stir and heat at 55°C for 2 hours, so that the system is completely dissolved and clarified to obtain glue; the solvent is decompressed or centrifuged Degassing, keeping at 45°C, immersing the template for preparing capsules int...

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Abstract

The invention discloses hydroxypropyl starch copolymer hollow capsules and a preparation method thereof, and belongs to the technical field of medicinal auxiliary materials. A preparation method of a hydroxypropyl starch copolymer sequentially comprises the following steps: adding hydroxypropyl starch, an esterification agent and a catalyst into a reaction container, adjusting a pH value, and stirring and heating for performing polymerization reaction; adding cellulose ether, a condensation agent and a reaction medium into the reaction container, and stirring and heating for performing polymerization reaction; and after reaction ends, cooling to room temperature, concentrating reaction liquid, then adding a precipitating agent, and filtering, washing and drying precipitates to obtain the hydroxypropyl starch copolymer. By adopting a preparation method of plant capsules which adopts a dipping process and takes the hydroxypropyl starch copolymer as a main raw material, the problems of too high production cost, complicated operation, unstable quality standards and uncontrollable quality generally existing in a current plant hollow capsule production process can be solved.

Description

Technical field: [0001] The invention relates to a preparation method of hydroxypropyl methylcellulose copolymer and plant capsule thereof, and belongs to the technical field of chemical synthesis and medical auxiliary materials. Background technique: [0002] Capsules (Capsules) have many advantages such as masking the taste of medicine, high efficacy, controlled and sustained release, etc., and are widely used in medicines, health products and functional foods. At present, the empty capsule products on the market are basically prepared from gelatin (Gelatin). Gelatin is produced by hydrolysis of animal bones and skins. Its unique molecular structure makes it difficult to overcome in application. Make the water solubility of the gelatin shell worse, resulting in the disintegration of the capsule shell and the delay of the dissolution of the capsule contents; gelatin can generate electrostatic charge accumulation under dry conditions, which will affect subsequent processing...

Claims

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Application Information

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IPC IPC(8): A61K47/36A61K9/48C08G81/00
Inventor 唐汝培吕兴富姜琼孙建刚马殿民
Owner SHANDONG RUIYUAN BIOTECH CO LTD