Poly lactic acid-glycolic acid (PLGA)-polyethylene glycol (PEG)-PLGA triblock copolymer and preparation method thereof

A PLGA-PEG-PLGA, PLGA technology is applied in the field of PLGA-PEG-PLGA triblock copolymer and its preparation, which can solve the problems of long preparation cycle, optimize the post-processing process, reduce the harmfulness of the solvent, reduce the reaction The effect of shortening time
CN104892912AActive Publication Date: 2015-09-09厦门瑞瓷医疗器械有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
厦门瑞瓷医疗器械有限公司
Publication Date
2015-09-09

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Abstract

The invention relates to processing of macromolecular materials, and in particular relates to a poly lactic acid-glycolic acid (PLGA)-polyethylene glycol (PEG)-PLGA triblock copolymer and a preparation method thereof. According to the PLGA-PEG-PLGA triblock copolymer provided by the invention, the number-average molecular weight of the PLGA is more than 2,000; and the number-average molecular weight of the PEG is 2 to 5 times that of the PLGA. Compared with the traditional PLGA-PEG-PLGA which is matched and polymerized by PLGA and PEG with Mn less than 2,000, the aqueous solution of the PLGA-PEG-PLGA triblock copolymer provided by the invention has a wider solution-gel conversion area.
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Description

technical field

[0001] The invention relates to polymer material processing, in particular to a PLGA-PEG-PLGA triblock copolymer and a preparation method thereof. Background technique

[0002] Polylactic acid glycolic acid (PLGA) is a copolymer formed by the polymerization of lactic acid and glycolic acid. Therefore, it is widely used in pharmaceuticals, medical engineering materials and modern industrial fields. It has passed FDA certification in the United States PLGA and has been officially included in the United States Pharmacopoeia as a pharmaceutical excipient.

[0003] The PLGA-PEG-PLGA triblock copolymer formed by the polymerization of PLGA and polyethylene glycol (PEG) has attracted extensive attention as a research hotspot of biopolymer hydrogel materials due to its excellent properties.

[0004] However, in the current research on the preparation of PLGA-PEG-PLGA triblock copolymer hydrogels, most of the investigations are the matching polymerization of small mol...

Claims

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