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Poly lactic acid-glycolic acid (PLGA)-polyethylene glycol (PEG)-PLGA triblock copolymer and preparation method thereof

A PLGA-PEG-PLGA, PLGA technology is applied in the field of PLGA-PEG-PLGA triblock copolymer and its preparation, which can solve the problems of long preparation cycle, optimize the post-processing process, reduce the harmfulness of the solvent, reduce the reaction The effect of shortening time

Active Publication Date: 2015-09-09
厦门瑞瓷医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] However, the method takes a long time to prepare

Method used

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  • Poly lactic acid-glycolic acid (PLGA)-polyethylene glycol (PEG)-PLGA triblock copolymer and preparation method thereof
  • Poly lactic acid-glycolic acid (PLGA)-polyethylene glycol (PEG)-PLGA triblock copolymer and preparation method thereof
  • Poly lactic acid-glycolic acid (PLGA)-polyethylene glycol (PEG)-PLGA triblock copolymer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1 PLGA-PEG-PLGA triblock copolymer and its preparation

[0047] 1.1 Raw materials: L-lactic acid, analytically pure, Aladdin Reagent (Shanghai) Co., Ltd.; glycolic acid, analytically pure, Aladdin Reagent (Shanghai) Co., Ltd.; stannous chloride (SnCl 2 2H 2 O), superior grade, Anaiji Chemical (import); Methanesulfonic acid (MSA), superior grade, Anaiji Chemical (import); PEG (PEG-2000, PEG-6000, PEG-8000, PEG -10000, PEG-20000), analytically pure, Aladdin Reagent (Shanghai) Co., Ltd.

[0048] 1.2 Instruments

[0049]Fourier Transform Infrared Spectrometer (FT-IR): Nicolet Avatar 330, American Thermoelectric Company; Nuclear Magnetic Resonance Spectrometer (NMR): Avance Ⅲ 400MHz, Swiss Bruker Company; Gel Permeation Chromatography (GPC): Breeze2, American Waters Company; UV- Visible Spectrophotometer (UV-Vis): UV-2100, Shimadzu Corporation; Synchronous Thermal Analyzer (SDT): SDT Q600, American TA Instruments; Intelligent Release Tester: ZRS-8GD, Tianda Tia...

Embodiment 2

[0064] The difference between this embodiment and Example 1 is that the steps of synthesizing PLGA-PEG-PLGA copolymer are as follows:

[0065] (1) Weigh a certain amount of PLGA with known number-average molecular weight above, and weigh a corresponding amount of PEG with different molecular weights according to the molar ratio of PLGA and PEG of 2:1 (refer to Table 2 for the corresponding matching of PLGA and PEG molecular weight), Add it into a 50mL three-necked flask; wherein, the number-average molecular weight of PEG is 3.7 times that of PLGA, see Table 2 to select and match PLGA (Mn=5411) and PEG (Mn=20000) with gel regions.

[0066] (2) Nitrogen or inert gas was introduced under normal pressure, heated to 110° C. with an electric heating mantle under magnetic stirring, and reacted for 18 hours. Obtain the crude product of PLGA-PEG-PLGA triblock polymer with different molecular weight matching, and cool to room temperature under nitrogen or inert gas atmosphere;

[0067...

Embodiment 3

[0071] The difference between this embodiment and Example 1 is that the steps of synthesizing PLGA-PEG-PLGA copolymer are as follows:

[0072] (1) Weigh a certain amount of PLGA with known number-average molecular weight above, and weigh a corresponding amount of PEG with different molecular weights according to the molar ratio of PLGA and PEG of 2:1 (refer to Table 2 for the corresponding matching of PLGA and PEG molecular weight), Add it into a 50mL three-necked flask; wherein, the number average molecular weight of PEG is 4 times that of PLGA, see Table 2 to select matching PLGA (Mn=2000) and PEG (Mn=8000) with gel regions.

[0073] (2) Nitrogen or inert gas was introduced under normal pressure, heated to 230° C. with an electric heating mantle under magnetic stirring, and reacted for 6 hours. Obtain the crude product of PLGA-PEG-PLGA triblock polymer with different molecular weight matching, and cool to room temperature under nitrogen or inert gas atmosphere;

[0074] (3)...

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Abstract

The invention relates to processing of macromolecular materials, and in particular relates to a poly lactic acid-glycolic acid (PLGA)-polyethylene glycol (PEG)-PLGA triblock copolymer and a preparation method thereof. According to the PLGA-PEG-PLGA triblock copolymer provided by the invention, the number-average molecular weight of the PLGA is more than 2,000; and the number-average molecular weight of the PEG is 2 to 5 times that of the PLGA. Compared with the traditional PLGA-PEG-PLGA which is matched and polymerized by PLGA and PEG with Mn less than 2,000, the aqueous solution of the PLGA-PEG-PLGA triblock copolymer provided by the invention has a wider solution-gel conversion area.

Description

technical field [0001] The invention relates to polymer material processing, in particular to a PLGA-PEG-PLGA triblock copolymer and a preparation method thereof. Background technique [0002] Polylactic acid glycolic acid (PLGA) is a copolymer formed by the polymerization of lactic acid and glycolic acid. Therefore, it is widely used in pharmaceuticals, medical engineering materials and modern industrial fields. It has passed FDA certification in the United States PLGA and has been officially included in the United States Pharmacopoeia as a pharmaceutical excipient. [0003] The PLGA-PEG-PLGA triblock copolymer formed by the polymerization of PLGA and polyethylene glycol (PEG) has attracted extensive attention as a research hotspot of biopolymer hydrogel materials due to its excellent properties. [0004] However, in the current research on the preparation of PLGA-PEG-PLGA triblock copolymer hydrogels, most of the investigations are the matching polymerization of small mol...

Claims

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Application Information

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IPC IPC(8): C08G63/664C08G63/08C08G63/90
Inventor 林旭夏海平刘迪敬祥林
Owner 厦门瑞瓷医疗器械有限公司
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