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An injectable-porous-drug-loaded polymethyl methacrylate-based composite scaffold bone graft material and its preparation method

A polymethyl methacrylate and composite stent technology, which is used in medical science, prosthesis, etc., can solve the problems of mismatching mechanical properties with natural bone, high polymerization reaction temperature, and shedding of surrounding tissue, so as to reduce the cost of treatment. , the matching of mechanical characteristics, the effect of improving the success rate

Active Publication Date: 2018-01-12
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the course of long-term clinical practice, some disadvantages of PMMA have gradually been exposed, such as mechanical properties that do not match natural bone, poor osseointegration, high polymerization temperature, infection, etc. Gradual loosening, detachment, and necrosis of surrounding tissue occur during the remodeling process, which may eventually lead to graft failure

Method used

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  • An injectable-porous-drug-loaded polymethyl methacrylate-based composite scaffold bone graft material and its preparation method
  • An injectable-porous-drug-loaded polymethyl methacrylate-based composite scaffold bone graft material and its preparation method
  • An injectable-porous-drug-loaded polymethyl methacrylate-based composite scaffold bone graft material and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] (1) Dissolve chitosan (CS) in a 0.1mol / L hydrochloric acid solution at room temperature to prepare a CS hydrochloric acid solution with a mass concentration of 2%. After the dissolution is complete, stir in an ice bath for 15 minutes.

[0043] (2) At the same time, dissolve sodium glycerophosphate (GP) in distilled water to prepare a 50% mass concentration GP solution, and place it in an ice bath for 15 minutes.

[0044] (3) Under constant stirring, slowly drop 0.5 mL of GP solution into 4.5 mL of CS hydrochloric acid solution, keep the solution free of turbidity, and stir for 20 minutes to obtain a uniformly mixed CS-GP solution.

[0045] (4) Add 25mg of gentamicin sulfate (GM) and 300mg of hydroxyapatite (HA) to the well-mixed CS-GP solution, and ultrasonic treatment to make it evenly mixed to obtain CS-GP / Nano-HA / GM mixture.

[0046] (5) Place the CS-GP / Nano-HA / GM mixed solution in a 37°C incubator, and form a CS-GP / Nano-HA / GM gel after 5 minutes.

[0047] (6) The CS-GP / Nano-...

Embodiment 2

[0050] (1) Dissolve chitosan (CS) in a 0.1mol / L hydrochloric acid solution at room temperature to prepare a CS hydrochloric acid solution with a mass concentration of 2%. After the dissolution is complete, stir in an ice bath for 15 minutes.

[0051] (2) At the same time, dissolve sodium glycerophosphate (GP) in distilled water to prepare a 50% mass concentration GP solution, and place it in an ice bath for 15 minutes.

[0052] (3) Under constant stirring, slowly drop 0.5 mL of GP solution into 4.5 mL of CS hydrochloric acid solution, keep the solution free of turbidity, and stir for 20 minutes to obtain a uniformly mixed CS-GP solution.

[0053] (4) Add 25mg vancomycin (VM) and 300mg hydroxyapatite (HA) to the well-mixed CS-GP solution, and ultrasonic treatment to make it evenly mixed to obtain a CS-GP / Nano-HA / VM mixed solution .

[0054] (5) Place the CS-GP / Nano-HA / VM mixed solution in a 37°C incubator and form a gel after 5 minutes.

[0055] (6) The CS-GP / Nano-HA / VM gel is freeze-dr...

Embodiment 3

[0058] (1) Dissolve chitosan (CS) in a 0.1mol / L hydrochloric acid solution at room temperature to prepare a CS hydrochloric acid solution with a mass concentration of 2%. After the dissolution is complete, stir in an ice bath for 15 minutes.

[0059] (2) At the same time, dissolve sodium glycerophosphate (GP) in distilled water to prepare a 50% mass concentration GP solution, and place it in an ice bath for 15 minutes.

[0060] (3) Under constant stirring, slowly drop 0.5 mL of GP solution into 4.5 mL of CS hydrochloric acid solution, keep the solution free of turbidity, and stir for 20 minutes to obtain a uniformly mixed CS-GP solution.

[0061] (4) Add 25mg of gentamicin sulfate (GM) and 300mg of hydroxyapatite (HA) to the well-mixed CS-GP solution, and ultrasonic treatment to make it evenly mixed to obtain CS-GP / Nano-HA / GM mixture.

[0062] (5) Place the CS-GP / Nano-HA / GM mixed solution in a 37°C incubator, and form a CS-GP / Nano-HA / GM gel after 5 minutes.

[0063] (6) Mix the powder ...

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Abstract

The present invention discloses an injectable-porous-drug loaded polymethyl methacrylate-based composite scaffold bone transplant material and a preparation method thereof, and belongs to the field of organic functional materials preparation. The polymethyl methacrylate-based composite scaffold bone transplant material uses polymethyl methacrylate (PMMA) as a scaffold for providing mechanical supporting, and a chitosan-based thermosensitive hydrogel as a pore forming agent and an osteoconductive material and a drug carrier, and the polymethyl methacrylate (PMMA) and the chitosan-based thermosensitive hydrogel are mixed with each other to form an injectable-porous three-dimensional structural bone cement composite. The scaffold bone transplant material is simple in preparation method, suitable in reaction temperature, and good in biocompatibility, has matched mechanical properties, good biological mineralization and corresponding anti-bacterial, anti-inflammatory or anti-tumor capabilities, and has broad prospects in clinical application of reconstruction of bone tissues in future.

Description

Technical field [0001] The invention belongs to the field of organic functional material preparation, and specifically relates to an injectable-porous-drug-loaded polymethyl methacrylate-based composite scaffold bone graft material and a preparation method thereof. Background technique [0002] Bone transplantation has been dedicated to repairing large-scale bone defects caused by trauma, tumor, infection, etc., in order to restore the body's function and beauty. It is one of the most common transplant operations. Bone transplantation is divided into autologous bone transplantation, allogeneic bone transplantation and artificial bone replacement material transplantation according to the source of the graft. Autologous bone transplantation is the gold standard for bone repair and bone reconstruction. However, due to the limited sources, it will cause secondary trauma and cannot provide initial stability. Its clinical application is greatly restricted. Allogeneic bone grafts are e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/56A61L27/54A61L27/50A61L27/16A61L27/20A61L27/12A61L27/10
Inventor 撒悦蒋滔王曼
Owner WUHAN UNIV
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