Gel for treating herpes zoster and preparation method thereof

A technology of herpes zoster and gel, which is applied in the field of gel for the treatment of herpes zoster and its preparation, which can solve problems such as adverse reactions, irrelevant treatment, and drug resistance of viruses, and achieve no skin irritation and relieve pain. Inflammatory response and the effect of accelerating the repair of damaged nerves

Active Publication Date: 2015-09-23
济南众志康成药物研发有限公司
View PDF2 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Such a large dose can easily lead to drug resistance of the virus, and it often brings adverse reactions not related to treatment

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Gel for treating herpes zoster and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: the preparation that is used for the treatment of the gel of herpes zoster

[0029] Formula: Acyclovir 3%, Lidocaine Hydrochloride 2%, Tacrolimus 0.1%, Vitamin B12 0.05%, Gel Matrix 1%, Neutralizer 1.2%, Humectant 5%, Solvent 30%, 2% solubilizer, 1% absorption promoter, and the balance is water;

[0030] The gel matrix is ​​carbomer 940; the neutralizing agent is triethanolamine; the moisturizing agent is glycerin; the solvent is ethanol; the solubilizing agent is Tween 80;

[0031] Preparation:

[0032] (1) Take the gel matrix of the prescribed amount, add 30 times the weight of water to dissolve, add a neutralizer dropwise to adjust the pH value to 5.5-6.0;

[0033] (2) Get another prescription amount of lidocaine hydrochloride and vitamin B12, add 5 times the weight of water to dissolve;

[0034] (3) Acyclovir and tacrolimus are dissolved in a solvent, and then a moisturizing agent is added;

[0035] (4) Add the solution of step (2) and step (3) to ...

Embodiment 2

[0036] Embodiment 2: the preparation that is used for the treatment of the gel of herpes zoster

[0037] Formula: Acyclovir 2%, Lidocaine Hydrochloride 3%, Tacrolimus 0.05%, Vitamin B12 0.06%, Gel Matrix 0.5%, Neutralizer 1.5%, Humectant 4%, Solvent 35%, 1% solubilizer, 1.5% absorption accelerator, and the balance is water.

[0038] The gel matrix is ​​carbomer 940; the neutralizing agent is triethanolamine; the moisturizing agent is glycerin; the solvent is ethanol; the solubilizing agent is Tween 80;

[0039] The preparation method is the same as in Example 1.

Embodiment 3

[0040] Embodiment 3: the preparation that is used for the treatment of the gel of herpes zoster

[0041] Acyclovir 4%, Lidocaine Hydrochloride 1%, Tacrolimus 0.15%, Vitamin B12 0.04%, Gel Matrix 1.5%, Neutralizer 1.5%, Humectant 6%, Solvent 25%, Solubilizer 3%, 0.5% of absorption-promoting agent, and the balance is water.

[0042] The gel base is carbomer 940; the neutralizing agent is triethanolamine; the moisturizing agent is glycerin; the solvent is ethanol; the solubilizing agent is Tween 80;

[0043] The preparation method is the same as in Example 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses gel for treating herpes zoster. The gel is prepared from the following raw materials in percentage by weight: 2-4 percent of acyclovir, 1-3 percent of lidocaine hydrochloride, 0.05-0.15 percent of tacrolimus, 0.04-0.06 percent of vitamin B12, 0.5-1.5 percent of a gel substrate, 1-1.5 percent of a neutralizer, 4-6 percent of a moisturizer, 25-35 percent of a solvent, 1-3 percent of a solubilizer, 0.5-1.5 percent of an absorption enhancer and the balance of water. The gel substrate is any one or more of carbopol 940, hydroxypropyl methyl cellulose, alginate, gelatin or starch; the neutralizer is triethanolamine or sodium hydroxide; the moisturizer is glycerin; the solvent is ethyl alcohol; the solubilizer is tween-80; the absorption enhancer is laurocapram. The invention also discloses a preparation method of the gel. All medicine components in the gel have a synergistic effect, the dosage of the medicines can be reduced, and the adverse reaction of the medicines is reduced.

Description

technical field [0001] The invention relates to a gel for treating herpes zoster and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Shingles is a skin disease caused by a virus that can occur anywhere on the body. It is more likely to occur in the distribution areas of the trigeminal nerve, vertebral nerve, intercostal nerve and lumbosacral nerve. Because it invades the nerve, the patient suffers from unbearable pain, so timely treatment is particularly important. [0003] Clinically, antiviral drugs for the treatment of herpes zoster mainly include ribavirin, acyclovir, valaciclovir, valacyclovir, and penciclovir. In the process of treating herpes zoster, the above-mentioned drugs exert their medicinal effects by directly acting on the virus, and exhibit antiviral activity by inhibiting the replication of viral DNA or acting on enzymes related to DNA replication. [0004] However, viruses have s...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/522A61K9/06A61P31/22A61P29/00A61K31/167A61K31/436A61K31/51
Inventor 李绍文戴晓莉
Owner 济南众志康成药物研发有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap