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A kind of traditional Chinese medicine nasal cavity anti-inflammatory preparation and preparation method thereof

A nasal cavity and traditional Chinese medicine technology, applied in anti-inflammatory agents, pharmaceutical formulas, non-central analgesics, etc., can solve the problems of steroid hormone safety controversy, long-term use, and ineffective effects, so as to avoid liver first pass Effect, fast onset, remarkable curative effect

Active Publication Date: 2018-08-10
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the above-mentioned drugs treat the symptoms but not the root cause. They need to be used for a long time, and they are easy to rebound after stopping the drugs. Antihistamines, antibiotics and ketotifen also have side effects to varying degrees. The safety of steroid hormones is even more controversial.
There are also many problems in the treatment of rhinitis and sinusitis with traditional Chinese medicine. Most of the treatment medicines are oral Chinese medicine preparations. After oral absorption and metabolism, the effective concentration at the nasal cavity is low, the onset of action is slow, and the effect is not obvious; most of the external medicines contain the vasoconstriction drug ephedra , there may be side effects such as anxiety, tremor, headache, insomnia, hot flashes, mental abnormalities, epilepsy, stroke, and cardiovascular system, and it is not suitable to overdose for a long time

Method used

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  • A kind of traditional Chinese medicine nasal cavity anti-inflammatory preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The traditional Chinese medicine nasal cavity anti-inflammatory preparation described in this example includes the following raw materials and their mass percentages: 0.1% of fulvic acid salt, 20% of honeysuckle, 5% of licorice, 2% of forsythia, 15% of Angelica dahurica, 10% of asarum, and 1 %, borneol 5%, peppermint extract 1%, and the balance is conventional auxiliary materials.

[0032] The preparation method of Chinese medicine nasal cavity anti-inflammatory preparation of the present invention specifically comprises the following steps:

[0033] (1) Weigh honeysuckle, licorice, forsythia, angelica dahurica, asarum, lampstand leaves, and ice flakes, put them into a container, add water and decoct twice, each decoction for 0.5h, filter the extract, and concentrate under reduced pressure to 1g crude drug / ml extract;

[0034] (2) Place it at room temperature for 1 hour, add pure water to mix, the volume of pure water is twice the volume of the extract, add sodium hyd...

Embodiment 2

[0038] The traditional Chinese medicine nasal cavity anti-inflammatory preparation described in this example includes the following raw materials and their mass percentages: 10% fulvic acid salt, 12% honeysuckle, 1% licorice, 5% forsythia, 10% Angelica dahurica, 1% asarum, and 5% leaves %, borneol 3%, peppermint extract 5%, and the balance is conventional auxiliary materials.

[0039] The preparation method of Chinese medicine nasal cavity anti-inflammatory preparation of the present invention specifically comprises the following steps:

[0040] (1) Weigh honeysuckle, licorice, forsythia, angelica dahurica, asarum, lampstand leaves, and borneol, put them into a container, add water and decoct twice, each decoction for 1 hour, filter the extract, and concentrate under reduced pressure to 1g crude drug / ml Extraction solution;

[0041] (2) Place it at room temperature for 1.5 hours, add pure water to mix, the volume of pure water is 3 times of the volume of the extract, add pota...

Embodiment 3

[0045] The traditional Chinese medicine nasal cavity anti-inflammatory preparation described in this example includes the following raw materials and their mass percentages: 20% fulvic acid salt, 5% honeysuckle, 3% licorice, 1% forsythia, 1% Angelica dahurica, 15% asarum, and 10% of the leaves %, borneol 1%, peppermint extract 3%, and the balance is conventional auxiliary materials.

[0046] The preparation method of Chinese medicine nasal cavity anti-inflammatory preparation of the present invention specifically comprises the following steps:

[0047] (1) Weigh honeysuckle, licorice, forsythia, angelica dahurica, asarum, lampstand leaves, and ice flakes, put them in a container, add water and decoct twice, decoct for 2 hours each time, filter the extract, and concentrate under reduced pressure to 1g crude drug / ml Extraction solution;

[0048] (2) Place it at room temperature for 2 hours, add pure water to mix, the volume of pure water is twice the volume of the extract, add ...

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Abstract

The invention discloses a traditional Chinese medicine anti-inflammatory preparation for a nasal cavity and a preparation method of the traditional Chinese medicine anti-inflammatory preparation, and belongs to the technical field of pharmacy of traditional Chinese medicines. The traditional Chinese medicine anti-inflammatory preparation disclosed by the invention comprises the following raw materials in percentage by mass: 0.1%-20% of fulvate, 5%-20% of honeysuckle flower, 1%-5% of liquorice, 1%-5% of fructus forsythia, 1%-15% of radix angelicae, 1%-15% of asarum, 1%-10% of common alstonia leaf, 1%-5% of borneol, 1%-5% of a mint extract and the balance of conventional auxiliary materials. The traditional Chinese medicine anti-inflammatory preparation disclosed by the invention can be prepared into a nasal spray, a gel and a nasal drop; and nasal and nasal sinus inflammatory diseases are locally treated. The traditional Chinese medicine anti-inflammatory preparation disclosed by the invention has the characteristics of fast acting, accurate curative effect, good compliance, mild medicine property, and is safe and reliable; and clinical application and patient application are facilitated.

Description

technical field [0001] The invention relates to a traditional Chinese medicine nasal cavity anti-inflammatory preparation and a preparation method thereof, belonging to the technical field of traditional Chinese medicine pharmacy. Background technique [0002] Rhinitis refers to nasal mucosal inflammation caused by viruses, bacteria, allergens, various physical and chemical factors, and certain systemic diseases. The clinical symptoms vary, and the main pathological changes are nasal mucosal congestion, swelling, exudation, hyperplasia, atrophy or necrosis, etc. . Sinusitis refers to inflammation of the sinus mucosa. Rhinitis and sinusitis are common and frequently-occurring diseases in ENT surgery. They are easy to occur, difficult to cure, and very harmful. When the physiological function of the nasal cavity is affected, breathing disorder occurs, affecting the function and metabolism of other tissues and organs, headache, dizziness, chest tightness, chest pain, listless...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/634A61P11/02A61P29/00
Inventor 何静宋游行陈绍军李宝才王美玲李家权徐俊刚王素梅
Owner KUNMING UNIV OF SCI & TECH
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