A kind of pharmaceutical composition and application thereof for promoting skin healing

Abstract

The invention relates to a pharmaceutical composition for promoting skin healing, which comprises a muscarinic receptor blocker and a cholinesterase inhibitor. The composition is applied to individuals with skin wounds (including humans and animals), so that the new granulation tissue is thicker, the collagen content is higher, the epidermal healing speed is faster, and there is no obvious side effect. Renal function was not significantly affected. The medicament for promoting skin healing prepared by the pharmaceutical composition of the invention can better promote epidermal healing without obvious toxic and side effects, and has good application prospects.

Description

technical field [0001] The invention belongs to the technical field of skin healing pharmaceuticals, and relates to a pharmaceutical composition for promoting skin healing and its application. Background technique [0002] Skin is the body's first barrier against external stimuli and damage. Damage to the skin and various tissues caused by mechanical injury factors will lead to microbial invasion, water and protein loss, endocrine and immune dysfunction, and severe cases can cause body death. During the treatment of many diseases, such as necessary surgical operations, severe skin and organ trauma will also be caused. According to previous clinical experience, in the healing process of wounds, incisions and various anastomotics of patients with trauma or surgery, poor healing can lead to wound or incision infection, incision dehiscence, such as poor healing of digestive tract anastomotics. Complications such as intestinal leakage, pancreatic leakage, or bile leakage may oc...

AI Technical Summary

Problems solved by technology

Traditional plant-based dressings such as gauze and bandages are the most widely used natural dressings so far, which can absorb wound secretions and prevent local fluid accumulation, but the disadvantage is that they are easy to dry and stick to the wound

Synthetic topical dressing is a kind of dressing that has been researched more at present. There are many kinds of dressings, which mainly use the special properties of polymers, such as film-forming and antibacterial properties, to provide wounds with a moist environment suitable for cell growth; such as gelatin, fruit, etc. The hydrocolloid dressing made of glue and carboxymethyl fiber has good mechanical properties, but it may cause pollution to the wound surface after absorbing a large amount of exudate; the water-soluble polymer material or its monomer is processed by a special process Hydrogel dressing, with good biocompatibility and strong absorption capacity, can closely adhere to the wound to achieve the effect of preventing bacteria and infection, but it is easy to dry and harden, causing discomfort

Composite dressings are generally multi-layered dressings, the outer layer is made of polymer materials, and the inner layer is composed of biological materials. It combines the characteristics of polymer materials to prevent bacteria and breathability and the good tissue compatibility of biological materials, and has good water permeability. These methods are easy to cause wound dehydration, which is not conducive to the crawling of epithelial cells, the dressing is easy to stick to the wound, and it is easy to cause mechanical damage when changing the dressing, which is not conducive to wound healing; moreover, for large surgical operations, especially Internal organs, deep tissue and skin trauma caused by thoracoabdominal surgery have no effect, so deep tissue wound healing may require systemic use of drugs to achieve the effect of promoting wound healing

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