Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of multifunctional drug combination and its preparation method and application

A multi-functional and pharmaceutical technology, applied in the direction of drug combination, pharmaceutical formula, heterocyclic compound active ingredients, etc., can solve the problems of difficult treatment, unsatisfactory treatment effect, easy disease, etc., to reduce the dosage of drugs, reduce the side effects of drugs, The effect of high-efficiency synergy

Inactive Publication Date: 2018-01-16
CHENGDU QIANKUN VETERINARY PHARMA
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Under the influence of the body of the mother animal, especially the abnormality of the udder, and the environment, the young animals with weaker physique are prone to the disease, and once the disease occurs, it is often difficult to treat or the treatment effect is not satisfactory
The reason is that young animals are born shortly after birth, have weak resistance, acute onset and a short course of disease. The use of existing traditional medicines for treatment often requires compulsory measures such as injection or gavage due to the single function and poor palatability of the medicine. drug, repeat
Therefore, the effect of the drug is not timely or the young animal is frightened to produce a stress response, etc., which greatly reduces the therapeutic effect of the young animal disease

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of multifunctional drug combination and its preparation method and application
  • A kind of multifunctional drug combination and its preparation method and application
  • A kind of multifunctional drug combination and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] The type, dosage and combination of auxiliary materials are important factors of the preparation, which are directly related to whether the preparation can be obtained and the quality of the preparation obtained. For the present invention, the most important inspection indexes are palatability and disintegration speed. In order to prepare orally rapidly disintegrating tablets with good palatability and fast disintegration speed, the formulation of the present invention is screened.

[0057] Preparation of different formulated products

[0058] According to the following formula and process to prepare different multi-functional zaijieding respectively.

[0059] Formulation: See Table 1.

[0060] Table 1 Design schemes of different formula ratios

[0061]

[0062] Process: Take MCC, L-HPC, SDS, SB, sodium glycyrrhizinate and fresh milk essence, mix them evenly, pulverize them, pass through a 200-mesh sieve, and use them as material A; take atropine sulfate, amvaloxa...

Embodiment 2

[0064] Take 9kg of microcrystalline cellulose (MCC), 2.1kg of low-substituted hydroxypropyl cellulose (L-HPC), 0.1kg of sodium dodecylsulfonate (SDS), 0.2kg of sodium hydroxypropylbutylate (SB), and 0.2kg of glycyrrhizic acid Sodium 0.05kg and fresh milk essence 0.05kg, mix well, pulverize, pass through 200 mesh sieve, it is A material; Take atropine sulfate 0.05kg, amvalide sulfate 0.3kg, sodium glutamate (MSG) 0.15kg, chloride Dissolve 0.1kg of potassium in 10kg of water, add 10kg of sucrose, mix, heat to make a paste; add 4kg of norfloxacin nicotinate, 6.7kg of glucuronate and 4kg of material A while hot, mix well, and make a soft material; into 60-mesh fine granules; add 0.2kg of magnesium stearate, mix evenly, and spheronize on a spheronizer to prepare round granules; dry; add 67kg of mannitol and the remaining material A, mix evenly, and press into 100,000 tablets.

Embodiment 3

[0066]Take 16kg of MCC, 3.2kg of L-HPC, 0.3kg of SDS, 0.4kg of SB, 0.2kg of sodium glycyrrhizinate and 0.2kg of fresh milk essence, mix them evenly, pulverize them, pass through a 200-mesh sieve, and use them as material A; take 0.1kg of atropine sulfate, Dissolve 0.1kg of amphetamine sulfate, 0.8kg of MSG, and 0.3kg of potassium chloride in 10kg of water, add 18kg of sucrose, mix, and heat to make a paste; while hot, add 6kg of norfloxacin nicotinate and 4.6kg of glucuronate Mix with 4kg of material A to make a soft material; make 60 mesh fine particles; add 0.8kg of magnesium stearate, mix evenly, and spheronize on a spheronizer to make round granules; dry; add 49kg of mannitol and the remaining A Materials, mixed, pressed into 100,000 pieces.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a multifunctional medicine for young animal diarrhea, which comprises: 2-10 parts of norfloxacin nicotinic acid, 0.5-7.6 parts of glucuronide, 0.02-0.48 parts of atropine sulfate, and 0.02 parts of amphetamine sulfate -0.5 parts. Preferably, it also includes 16-80 parts of mannitol, 5-30 parts of sucrose, 0.05-2 parts of sodium glutamate, 0.05-0.6 parts of potassium chloride, 0.1-0.8 parts of sodium hydroxypropyl butylate, and 0.05-05 parts of magnesium stearate 1.8 parts, 0.01-0.6 parts of sodium glycyrrhizinate, 0.01-0.5 parts of fresh milk essence, 4-30 parts of microcrystalline fiber, 0.6-6 parts of low-substituted hydroxypropyl cellulose, 0.01-0.7 parts of sodium lauryl sulfate . The invention also discloses a method for preparing the medicine. The invention also discloses the application of the medicine in the treatment of diarrhea in young animals. The medicine of the present invention can achieve detoxification, sterilization and antidiarrheal effects, and each medicine component can realize efficient synergistic effect, thereby reducing the dosage of the medicine and significantly reducing the side effects of the medicine; it can make the young animals take the medicine actively, avoiding the stress response The production; can release drugs in a short time, very conducive to absorption.

Description

technical field [0001] The invention belongs to the field of treatment of diarrhea in young animals, and in particular relates to a multifunctional medicine combination and its preparation method and application, and more particularly relates to a multifunctional medicine for diarrhea in young animals and its preparation method and application. Background technique [0002] Whether it is in animal husbandry or in pet breeding, the disease prevention and treatment of young animals has always been a difficult problem. Since the young animals are just born, the body has not had time to respond to immunity through vaccination. Therefore, the young animals are not only threatened by pathogens in the environment, but the mother animal is also a source of disease for the young animals while providing breast milk. Under the influence of the mother animal's body, especially the abnormality of the udder, and the environment, the young animals with weaker physique are prone to the dise...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K31/496A61K31/46A61K31/137A61K47/10A61K47/26A61K47/02A61K47/14A61K47/12A61K47/38A61K47/20A61P1/12
Inventor 丁晓刚李犹平吴学渊
Owner CHENGDU QIANKUN VETERINARY PHARMA