Houttuynia eyedrop and preparation method thereof

A technology of Houttuynia cordata and eye drops, which is applied in the field of medicine, can solve problems such as uncertain efficacy of specific ingredients, difficulty in finding index ingredients, complex natural medicinal ingredients, etc., and achieve the effects of clear ingredients, convenient preparation, and stable quality

Active Publication Date: 2015-10-21
SICHUAN SUNNYHOPE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above reports only illustrate the main components of Houttuynia cordata. Due to the complex components of natural medicinal materials, it is impossible to determine the specific compone

Method used

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  • Houttuynia eyedrop and preparation method thereof
  • Houttuynia eyedrop and preparation method thereof
  • Houttuynia eyedrop and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A kind of Houttuynia cordata eye drops, which is prepared by Houttuynia cordata extract as an active ingredient, plus pharmaceutically acceptable ophthalmic preparation auxiliary materials, the Houttuynia cordata extract contains 1 μg of methyl n-nonanone / ml, 4-terpineol 0.1μg / ml, ɑ-terpineol 0.01μg / ml, bornyl acetate 0.01μg / ml.

[0026] Wherein, the ophthalmic preparation auxiliary materials include surfactants, osmotic pressure regulators, bacteriostats, pH value buffers and antioxidants. The surfactant is Span; the osmotic pressure regulator is sodium chloride; the bacteriostatic agent is benzalkonium chloride; the pH buffer is phosphate; and the antioxidant is Vc. The pH value of the Houttuynia cordata eye drops is 5.

[0027] The preparation method of above-mentioned Houttuynia cordata eye drops, it may further comprise the steps:

[0028] S1. Soaking: take fresh Houttuynia cordata, add a sodium chloride solution whose volume is 1 times the weight of Houttuynia ...

Embodiment 2

[0033] A kind of Houttuynia cordata eye drops, which is prepared by Houttuynia cordata extract as an active ingredient, plus pharmaceutically acceptable ophthalmic preparation auxiliary materials, the Houttuynia cordata extract contains 10 μg of methyl n-nonanone / ml, 4-terpineol 10μg / ml, ɑ-terpineol 2.5μg / ml, bornyl acetate 2.5μg / ml.

[0034] Wherein, the ophthalmic preparation auxiliary materials include surfactants, osmotic pressure regulators, bacteriostats, pH value buffers and antioxidants. The surfactant is sorbitol; the osmotic pressure regulator is sodium chloride; the bacteriostatic agent is benzalkonium bromide; the pH buffer is citrate; the antioxidant is Vc - Palmitate. The pH value of the Houttuynia cordata eye drops is 7.

[0035] The preparation method of above-mentioned Houttuynia cordata eye drops, it may further comprise the steps:

[0036] S1. Soaking: Take fresh Houttuynia cordata, add a sodium chloride solution whose volume is 10 times the weight of Ho...

Embodiment 3

[0041] A kind of Houttuynia cordata eye drops, which is prepared by Houttuynia cordata extract as an active ingredient, plus pharmaceutically acceptable ophthalmic preparation auxiliary materials, the Houttuynia cordata extract contains 2 μg of methyl n-nonanone / ml, 4-terpineol 6 μg / ml, ɑ-terpineol 1.2 μg / ml, bornyl acetate 1.0 μg / ml.

[0042] Wherein, the ophthalmic preparation auxiliary materials include surfactants, osmotic pressure regulators, bacteriostats, pH value buffers and antioxidants. The surfactant is poloxamer; the osmotic pressure regulator is sodium chloride; the antibacterial agent is ethylparaben; the pH buffer is acetate; sodium bisulfite. The pH value of the Houttuynia cordata eye drops is 6.

[0043]The preparation method of above-mentioned Houttuynia cordata eye drops, it may further comprise the steps:

[0044] S1. Soaking: take fresh Houttuynia cordata, add a sodium chloride solution whose volume is 2 times the weight of Houttuynia cordata for soaki...

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Abstract

The invention discloses houttuynia eyedrop and a preparation method thereof. The houttuynia eyedrop is prepared by houttuynia extract as an active ingredient and ophthalmic preparations auxiliary materials accepted pharmaceutically. The houttuynia extract contains 1-10 micrograms/ml of 2-undecanone, 0.1-10 micrograms/ml of 4-carvomenthenol, 0.01-2.5 micrograms/ml of alpha-terpineol and 0.01-2.5 micrograms/ml of bornyl acetate. The preparation method of the houttuynia eyedrop comprises the steps of soaking, distillation, redistillation and addition of auxiliary materials. The houttuynia eyedrop is definite in ingredient and stable and controllable in quality; the preparation method is easy to operate, the houttuynia eyedrop is convenient to prepare, and the houttuynia eyedrop and the preparation method thereof are suitable for large-scale industrial production.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to Houttuynia cordata eye drops and a preparation method thereof. Background technique [0002] Houttuynia cordata is the rooted whole plant of the perennial herbaceous plant Houttuynia cordata Thunb. of the family Tribaceae. It is famous for Pleurotus chinensis, Purple Houttuynia, Pig Nostril, Nine-section Lotus, etc. Its fresh plants have a pungent fishy smell after being broken. Widely distributed in the central, southeast and southwest provinces and autonomous regions of my country, especially in Hunan, Hubei, Sichuan, Jiangsu and other provinces. Houttuynia cordata has the effects of clearing heat and detoxifying, eliminating carbuncle and draining pus, diuresis and treating stranguria. Studies have shown that Houttuynia cordata contains volatile components, flavonoids, organic acids, sterols, alkaloids and other components. Houttuynia cordata is mainly eaten as a working ...

Claims

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Application Information

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IPC IPC(8): A61K36/78A61K9/08A61P27/02
Inventor 黄莜萍王建波陈开军李涛程亮聂飞范世德胥勤
Owner SICHUAN SUNNYHOPE PHARM CO LTD
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