Solid dispersion prepared from magnolol, honokiol or mixture of magnolol and honokiol and preparation method of solid dispersion by hot-melt extrusion
A solid dispersion and honokiol technology, which is applied in the direction of active ingredients of hydroxyl compounds, medical preparations of non-active ingredients, antipyretics, etc., can solve the problems of unstable preparations and inability to apply to industrialized large-scale production, and achieve increased Dissolution, bioavailability improvement, and simple preparation process
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[0018] Example 1
[0019] Mix magnolol (1%), xylitol (10%), and copovidone S-630 (89%) uniformly, pass through a 60-mesh sieve to prepare a physical mixture, and set the extrusion temperature of the twin-screw extruder At 90°C, after the temperature rises to the set value and stabilizes, slowly increase the speed to 50 rpm, and add the physical mixture at a uniform speed to obtain a strip-shaped extrudate, which is cooled and pulverized through a 20-mesh sieve to obtain a solid dispersion powder of magnolol.
Example Embodiment
[0020] Example 2
[0021] Mix magnolol (20%), xylitol (20%), and copovidone S-630 (60%) uniformly, pass through an 80-mesh sieve to prepare a physical mixture, and set the extrusion temperature of the twin-screw extruder At 90°C, after the temperature rises to the set value and stabilizes, slowly increase the speed to 50 rpm, and add the physical mixture at a uniform speed to obtain a strip-shaped extrudate, which is cooled and crushed through a 100-mesh sieve to obtain a solid dispersion powder of magnolol.
Example Embodiment
[0022] Example 3
[0023] Mix Honokiol (50%), mannitol (10%), polyethylene caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (40%) uniformly, and pass through a 100 mesh sieve to prepare a physical mixture , Set the extrusion temperature of the twin-screw extruder at 90°C, after the temperature rises to the set value and is stable, slowly increase the speed to 50rpm, add the physical mixture at a uniform speed to obtain a strip-shaped extrudate, cool it, and crush it through 60 mesh Sieve to obtain magnolol solid dispersion powder.
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