3D printed digital artificial bone and its preparation method

A 3D printing and artificial bone technology, applied in additive processing, medical science, prosthesis, etc., can solve the problems of inconvenient repair and treatment for patients with bone defects, unsatisfactory curative effect, etc., to achieve stable and uniform size and properties, and absorption speed Stable, perfectly matched results

Active Publication Date: 2018-01-30
上海浦卫生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the fact that the artificial bone prepared by the existing technology and materials is difficult to match the natural bone, it brings a lot of inconvenience to the repair treatment of patients with bone defects, and the curative effect is difficult to be satisfactory.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The cortical bone material is PLA with a molecular weight of 300,000; the cancellous bone material is a mixture of PLA with a molecular weight of 90,000 and HA with a particle size of 20 nm, and the ratio of the two is 2:2.

[0020] The specific 3D printing process is:

[0021] According to the patient's CT, magnetic resonance imaging (MRI) and other images and data, obtain the 3D data of the patient's bone defect, use Simpleware 3.1 software to construct its specific CAD solid model, and convert it into an STL format file through the numerical control conversion of the forming machine , and then use the Med CAD software to cut out a series of slices with a thickness of 0.2mm, and then transfer the data of each slice above to the rapid automatic prototyping machine.

[0022] The material box of the rapid automatic molding machine contains PLA with a molecular weight of 300,000, and a mixture of PLA and HA with a molecular weight of 90,000.

[0023] Applying the princip...

Embodiment 2

[0028] The cortical bone material is PLA with a molecular weight of 300,000; the cancellous bone material is a mixture of PLA with a molecular weight of 90,000 and HA with a particle size of 30 nm, and the ratio of the two is 3:2.

[0029] The specific 3D printing process is:

[0030]According to the patient's CT, magnetic resonance imaging (MRI) and other imaging data, the 3D data of the patient's bone defect is obtained, and the specific CAD solid model is constructed using Simpleware 3.1 software, which is converted into an STL format file through the numerical control conversion of the forming machine. Then use the Med CAD software to cut out a series of sheets with a thickness of 0.2mm, and then transfer the data of each sheet above to the rapid automatic prototyping machine.

[0031] The material box of the rapid automatic molding machine contains PLA with a molecular weight of 300,000, and a mixture of PLA and HA with a molecular weight of 90,000.

[0032] Applying the...

Embodiment 3

[0037] The cortical bone material is PLA with a molecular weight of 300,000; the cancellous bone material is a mixture of PLA with a molecular weight of 90,000 and HA with a particle size of 50 nm, and the ratio of the two is 2:3.

[0038] The specific 3D printing process is:

[0039] According to the patient's CT, magnetic resonance imaging (MRI) and other imaging data, the 3D data of the patient's bone defect is obtained, and the specific CAD solid model is constructed using Simpleware 3.1 software, which is converted into an STL format file through the numerical control conversion of the forming machine. Then use the Med CAD software to cut out a series of sheets with a thickness of 0.2mm, and then transfer the data of each sheet above to the rapid automatic prototyping machine.

[0040] The material box of the rapid automatic molding machine contains PLA with a molecular weight of 300,000, and a mixture of PLA and HA with a molecular weight of 90,000.

[0041] Applying th...

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Abstract

The invention discloses a 3D printed digital artificial bone, the artificial bone is composed of cortical bone, cancellous bone and bone marrow cavity, the cortical bone is composed of L-polylactic acid or polyether ether ketone, and the cancellous bone is composed of Polylactic acid and hydroxyapatite are mixed, and the molecular weight of the L-lactic acid constituting the cortical bone is higher than that of the L-polylactic acid constituting the cancellous bone. The cortical bone and cancellous bone are simultaneously prepared by 3D printing process. The invention also discloses a 3D printing method of the digitized artificial bone. The artificial bone provided by the present invention has a porosity of cortical bone of 10% on the scale of microns and millimeters; a porosity of cancellous bone of 60-80% and a pore size of 120-220 μm, having pores similar to human bone structure rate, pore size and mechanical properties.

Description

technical field [0001] The invention relates to a 3D printed digital artificial bone and a preparation method thereof. Background technique [0002] The repair and reconstruction of traumatic or tumor bone defects has always been one of the difficult problems in orthopedics. Clinically, autologous bone transplantation is currently the most effective treatment method, but there are disadvantages such as limited materials, prolonged operation time, and secondary trauma to patients. Finding a safe and effective alternative to autologous bone grafting has always been a research hotspot in international orthopedics. [0003] Bone has a complex spatial structure, which is composed of cortical bone, cancellous bone, and bone marrow cavity from outside to inside, and its hierarchical structure includes nanoscale, microscale, millimeter, and centimeter levels. Bone is mineralized collagen fibers at the nanoscale, including collagen microfibrils and hydroxyapatite. Collagen microfi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/42A61L27/58A61L27/50B29C67/00B33Y10/00
Inventor 胡堃李路海余均武危岩杜彩霞
Owner 上海浦卫生物科技有限公司
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