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D-(-)-tartaric acid clean production process based on bipolar membrane electroosmosis technology

A technology of tartaric acid and sodium tartrate, applied in the fields of carboxylate preparation, organic chemistry, fermentation, etc., can solve problems such as low production efficiency, membrane blockage, low solubility, etc., to avoid cumbersome production steps, significant industrial application value and environmental benefits Effect

Inactive Publication Date: 2015-11-25
THE GREAT WALL BIO CHEM ENG CO LTD
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  • Abstract
  • Description
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Problems solved by technology

However, since the natural tartar is L-(+)-potassium hydrogen tartrate, and D-(-)-tartrate does not exist in large quantities in nature, this method is not applicable to D-(-)-tartrate On the other hand, in this method, although potassium hydrogen tartrate in tartar is converted into potassium tartrate with higher solubility by using potassium hydroxide before extraction, during the extraction process, due to the anion exchange membrane and cation The exchange membrane has different permeability to ions, and it is easy to form potassium hydrogen tartrate with low solubility (under 25°C, the solubility is only about 8g / L), which will lead to membrane clogging, which is not conducive to industrial use; To avoid unfavorable factors such as membrane clogging, the concentration of tartrate ions in the solution must be kept at a low level, resulting in low conductivity, and special conductive separators are required; and its production efficiency is also low

Method used

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  • D-(-)-tartaric acid clean production process based on bipolar membrane electroosmosis technology
  • D-(-)-tartaric acid clean production process based on bipolar membrane electroosmosis technology
  • D-(-)-tartaric acid clean production process based on bipolar membrane electroosmosis technology

Examples

Experimental program
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Effect test

Embodiment 1

[0036] In the following examples 2-4, the model of the bipolar membrane electrodialyzer used is CJ-BMED-A, produced by Hefei Kejia Polymer Material Technology Co., Ltd., with an overall size of 650×650×950mm, and a membrane stack The size is 170mm×110mm, and the ion exchange membrane is acid and alkali resistant. Preparation of Example 1D-type cis-epoxysuccinate hydrolase and its enzymatic hydrolysis

[0037] The gene fragment of SEQ ID NO: 1 was connected to the pBV220 plasmid vector, and then the recombinant plasmid was introduced into E.coliDH5α competent cells to obtain recombinant D-type cis-epoxysuccinate hydrolase engineering bacteria. The cultivation conditions of engineering bacteria are as follows: put 100mL of LB medium in a 500mL Erlenmeyer flask, pick a single colony of engineering bacteria and insert it into the medium, place it at 37°C and shake it at 200rpm. When OD600=0.6-0.8, set the temperature After raising the temperature to 42°C for 5 hours, the inductio...

Embodiment 2

[0039] Example 2 Salt / acid two-chamber electrodialysis device prepares D-(-)-tartaric acid

[0040] 2L is pumped into the salt chamber of salt / acid two-chamber electrodialyzer ( figure 2 ), while pumping 0.5L of 0.2M D-(-)-tartaric acid solution into the acid chamber at a rate of 40L / h to increase its conductivity. Control the voltage to maintain the current density at 140mA / cm 2 , the operating temperature is 40°C, the cycle reaction is 6h, the conversion rate of D-(-)-tartrate reaches 86%, the energy consumption is 2.09kW h / kg, the current efficiency is about 88%, and the D-(-)-tartrate The recovery rate reaches 95%.

Embodiment 3

[0041] Example 3 Acid / salt / alkali three-chamber electrodialysis device prepares D-(-)-tartaric acid

[0042] 2L is pumped into the salt chamber of acid / salt / alkali three chamber type electrodialyzer ( image 3 ), while pumping 1L0.2M D-(-)-tartaric acid solution into the acid chamber at a speed of 60L / h, and pumping 1L0.1M NaOH solution into the alkali chamber at a speed of 60L / h to increase its conductivity . Control the voltage to maintain the current density at 80mA / cm 2 , the operating temperature is 40°C, the cycle reaction is 6h, the conversion rate of D-(-)-tartrate reaches 90%, the energy consumption is 2.64kW h / kg, the current efficiency is about 90%, and the D-(-)-tartrate The recovery rate reaches 98%.

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Abstract

A purpose of the present invention is to provide a D-(-)-tartaric acid clean production process based on a bipolar membrane electroosmosis technology. The process comprises that: a cis-epoxy succinic acid sodium salt is hydrolyzed with D-type cis-epoxy succinic acid hydrolase (D-ESH) to obtain a D-(-)-sodium tartrate conversion solution; and the D-(-)-sodium tartrate contained in the D-(-)-sodium tartrate conversion solution is converted into D-(-)-tartaric acid through a bipolar membrane electordialyzer. According to the present invention, the current D-(-)-calcium tartrate acidification process can be replaced, the D-(-)-tartaric acid yield achieves more than or equal to 95%, and the additional acid is not required to provide H<+>; the generated NaOH solution can be used for synthesizing the precursor cis-epoxy sodium succinate, and the whole production process does not produce acid, alkali and salt waste solutions; and the production process has characteristics of environmental pollution reducing, raw material consumption reducing, significant industrial application values, and significant environmental benefits.

Description

technical field [0001] The invention relates to a clean production process of D-(-)-tartaric acid, in particular to the separation of D-(-)- A method for tartrate ions belongs to the field of membrane technology. Background technique [0002] D-(-)-Tartrate ((2S,3S)-2,3-dihydroxybutane-1,4-dicarboxylic acid) is uncommon in nature and is mainly used as a chiral source and chiral Resolving agents are used in the pharmaceutical industry. With the continuous development of industry, the demand for D-(-)-tartaric acid is also increasing year by year. [0003] At present, the method for producing D-(-)-tartaric acid in industry mainly adopts the chemical resolution method, and the racemic DL-tartaric acid is resolved into D-(-)-tartaric acid and L-(+)-tartaric acid ( For example, see US Pat. No. 6,346,649), or use special microorganisms to deplete L-(+)-tartaric acid in DL-tartaric acid (for example, see EP0311835B). These methods are difficult and expensive to operate, which ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P7/46C07C59/255C07C51/02
Inventor 周铁成王云山王自强周煜昊冯晓东龚树
Owner THE GREAT WALL BIO CHEM ENG CO LTD
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