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Pharmaceutical composition containing ginsenoside rb1 used as tmem16a ion channel activator

A technology of ginsenosides and ion channels, applied in the directions of drug combination, pharmaceutical formula, organic active ingredients, etc., can solve problems such as undiscovered and unretrieved, increased blood pressure, etc., and achieves easy operation, remarkable effect, and simple configuration method. Effect

Active Publication Date: 2018-06-22
HEBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Ginsenoside Rb1 is a kind of ginseng extract. The effects of ginsenoside Rb1 that have been reported in the prior art as drugs include: neuroprotective effects, central anti-stress effects, and enhanced learning and memory effects. The medicinal value is reflected in the effect on the cardiovascular system. It has a regulating effect on arrhythmia, can promote the release of catecholamines, and thus has a strong heart effect. In addition, it can increase blood pressure, resist atherosclerosis, and promote blood circulation. The activity of secreting ketones has a protective effect on lung and heart ischemia-reperfusion injury, but so far no ginsenosides containing ginsenosides have been found or retrieved for the treatment of TMEM16A / CaCCs ion channel-related diseases such as gastrointestinal motility disorders Reports and related literature on the pharmaceutical composition of Rb1

Method used

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  • Pharmaceutical composition containing ginsenoside rb1 used as tmem16a ion channel activator
  • Pharmaceutical composition containing ginsenoside rb1 used as tmem16a ion channel activator
  • Pharmaceutical composition containing ginsenoside rb1 used as tmem16a ion channel activator

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Experimental program
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Effect test

Embodiment 1

[0038] The pharmaceutical composition containing ginsenoside Rb1 of this embodiment uses ginsenoside Rb1 as an active ingredient, supplemented by a starch carrier, and the weight ratio of the amount of ginsenoside Rb1 to the starch carrier is 1:0.5, and its preparation method uses pharmaceutically acceptable The composition of the pharmaceutical composition containing ginsenoside Rb1 in this embodiment is a powder for oral administration.

Embodiment 2

[0040] The pharmaceutical composition containing ginsenoside Rb1 of this embodiment uses ginsenoside Rb1 as an active ingredient, supplemented by powdered sugar carrier, the weight ratio of the amount of ginsenoside Rb1 to powdered sugar carrier is 1:0.5, and its preparation method uses pharmaceutical Acceptable form, the pharmaceutical composition containing ginsenoside Rb1 in this embodiment is composed of granules for oral administration.

Embodiment 3

[0042] The pharmaceutical composition containing ginsenoside Rb1 of this embodiment uses ginsenoside Rb1 as an active ingredient, supplemented with a dextrin carrier, and the weight ratio of the amount of ginsenoside Rb1 to the dextrin carrier is 1:1, and its preparation method uses pharmaceutical Acceptable forms, the composition of the pharmaceutical composition containing ginsenoside Rb1 in this embodiment is a capsule for oral administration.

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Abstract

The invention discloses a medicine composition which is used as a TMEM16A ion channel activator and contains ginsenoside Rb1, and relates to medicine compositions. The medicine composition comprises the ginsenoside Rb1 and auxiliary pharmaceutically acceptable carriers. The ginsenoside Rb1 is an active ingredient, the auxiliary pharmaceutically acceptable carriers include starch, powdered sugar, dextrin, lactose, microcrystalline cellulose, mannitol or mixtures of 2-6 of the starch, the powdered sugar, the dextrin, the lactose, the microcrystalline cellulose and the mannitol, and a weight ratio of the active ingredient, namely, the ginsenoside Rb1, to the auxiliary pharmaceutically acceptable carriers is 1:0.5-1.5. The medicine composition is medicine for treating TMEM16A / CaCCs ion channel related diseases. The medicine composition has the advantage that novel medicine application of the ginsenoside Rb1 is developed.

Description

technical field [0001] The technical scheme of the present invention relates to a pharmaceutical composition, specifically a pharmaceutical composition containing ginsenoside Rb1 used as a TMEM16A ion channel activator. Background technique [0002] Ginsenoside Rb1, Chinese chemical name: (3β, 12β)-20-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammarate-24 -ene-3-y12-O-β-D-glucopyranosyl, English chemical name: (3beta,12beta)-20-[(6-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)oxy] -12-hydroxydammar-24-en-3-yl2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside. Ginsenoside Rb1 exists in the roots, stems and leaves of Araliaceae ginseng, in the roots, stems and leaves of American ginseng, in the roots and leaves of Panax notoginseng, and in the leaves and stems of Cucurbitaceae Jiaogulan, and its molecular formula is C 54 h 92 o 23 , the relative molecular weight is 1108.26, white powder, soluble in water, methanol and ethanol, soluble in n-butanol, acetic a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61P1/00
Inventor 展永郭帅陈娅斐安海龙王徐朝柴燃韩玥斌祁金龙张海林
Owner HEBEI UNIV OF TECH