Preparation method of medical pressure sensitive adhesive (PSA)

A pressure-sensitive adhesive and butyl rubber technology, applied in the direction of rosin adhesives, adhesive additives, non-polymer adhesive additives, etc., can solve the problems of incomplete peeling, poor stickiness, and large peeling force, and achieve Excellent adhesion and persistence, good integrity, and easy peeling effect

Inactive Publication Date: 2015-12-02
JIANGSU LANWAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the commonly used medical pressure-sensitive adhesive paste has a good effect, but there are problems such as poor stickiness, incomplete peeling, and high peeling force, which leads to a certain pain for the patient when pe

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A preparation method of medical pressure-sensitive adhesive, the steps are as follows:

[0018] Step 1: Add 2 parts by weight of butyl rubber, 7 parts of rosin glyceride, 6001 parts of polyethylene glycol, 1 part of calcium lignosulfonate, and 2 parts of sodium alginate into a mixer and stir and mix evenly, wherein The stirring speed of stirring and mixing is 100 rpm, the stirring time is 20 minutes, and the material 1 is obtained;

[0019] Step 2: Add 2 parts of diethyl phosphite and 3 parts of chlorinated paraffin into the material 1, mix evenly and then knead, the kneading temperature is 130°C, the kneading time is 30 minutes, and the kneaded product is obtained;

[0020] Step 3: Add 2 parts of maleamic acid and 3 parts of methacrylic acid to the kneading mixture, heat and stir for 30 minutes in the presence of nitrogen, and then knead again. The kneading temperature is 130°C and the kneading time is For 20 minutes, a medical pressure-sensitive adhesive is obtained....

Embodiment 2

[0022] A preparation method of medical pressure-sensitive adhesive, the steps are as follows:

[0023] Step 1, 3 parts by weight of butyl rubber, 8 parts of rosin glyceride, 8002 parts of polyethylene glycol, 2 parts of calcium lignosulfonate, and 3 parts of sodium alginate are added to the mixer and stirred and mixed evenly, wherein The stirring speed of stirring and mixing is 105 rpm, and the stirring time is 23 minutes, and the material 1 is obtained;

[0024] Step 2: Add 3 parts of diethyl phosphite and 5 parts of chlorinated paraffin into the material 1, mix evenly and then knead, the kneading temperature is 134°C, the kneading time is 38 minutes, and the kneaded product is obtained;

[0025] Step 3: Add 3 parts of maleamic acid and 4 parts of methacrylic acid to the mixture, heat and stir for 36 minutes in the presence of argon, and then carry out mixing. The mixing temperature is 133°C. The time is 25 minutes, and the medical pressure-sensitive adhesive is obtained.

Embodiment 3

[0027] A preparation method of medical pressure-sensitive adhesive, the steps are as follows:

[0028] Step 1, 5 parts by weight of butyl rubber, 8 parts of rosin glyceride, 8004 parts of polyethylene glycol, 2 parts of calcium lignosulfonate, and 3 parts of sodium alginate are added to the mixer and stirred evenly, wherein The stirring speed of stirring and mixing was 110 rpm, and the stirring time was 27 minutes to obtain material 1;

[0029] Step 2: Add 4 parts of diethyl phosphite and 6 parts of chlorinated paraffin into the material 1, mix evenly and then knead, the kneading temperature is 138°C, the kneading time is 42 minutes, and the kneaded product is obtained;

[0030] Step 3: Add 4 parts of maleamic acid and 5 parts of methacrylic acid to the mixture, heat and stir for 45 minutes in the presence of nitrogen, and then carry out mixing. The mixing temperature is 137°C and the mixing time is For 28 minutes, a medical pressure-sensitive adhesive was obtained.

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PUM

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Abstract

The invention discloses a preparation method of a medical pressure sensitive adhesive (PSA). The preparation method comprises the following steps: firstly adding 2-7 parts of butyl rubber, 7-10 parts of glycerol ester of rosin, 1-5 parts of polyethylene glycol, 1-3 parts of calcium lignosulphonate and 2-4 parts of sodium alginate by weight to a stirrer to be stirred and mixed uniformly to obtain a material I; secondly adding 2-5 parts of diethyl phosphite and 3-7 parts of chlorinated paraffin by weight to the material I, mixing the materials uniformly and then mixing the mixture to obtain a mixed product; and finally adding 2-5 parts of maleamic acid and 3-6 parts of methacrylic acid by weight to the mixed product, heating and stirring the materials for 30-50 minutes in the presence of an inert gas and then mixing, thus obtaining the medical PSA. The medical PSA provided by the invention has the beneficial effects that the initial adhesion achieves the degree of No.32 standard steel balls; the holding power is more than 115 minutes; and the medical PSA has low peel strength and good peel integrity and can be better applied to the medical field.

Description

technical field [0001] The invention belongs to the technical field of medical polymer materials, and in particular relates to a preparation method of medical pressure-sensitive adhesive. Background technique [0002] Pressure-sensitive adhesives are referred to as pressure-sensitive adhesives for short. They are adhesive at room temperature and can be bonded with a little pressure. Pressure-sensitive adhesives and their products have developed into an independent branch of adhesives. There are two types of pressure-sensitive adhesives: rubber type and resin type. The rubber type can be natural rubber or synthetic rubber, and the largest amount is natural rubber. Resin-type acrylate pressure-sensitive adhesives are the most important. In terms of form, pressure sensitive adhesives are divided into solvent type, emulsion type, hot melt type and liquid curing type. The output of solvent-based pressure-sensitive adhesives is gradually decreasing due to high solvent prices, t...

Claims

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Application Information

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IPC IPC(8): C09J193/04C09J123/22C09J105/04C09J11/08C09J11/06
Inventor 章祥庆唐海健
Owner JIANGSU LANWAN BIOTECH
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