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Medicine composite containing erythromycin thiocyanate and preparation method thereof

A technology containing erythromycin thiocyanate and erythromycin thiocyanate is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, antibacterial drugs, etc. To achieve the effects of good stability, increased residence time, and improved bioavailability

Active Publication Date: 2015-12-09
QINGDAO KDN BIOTECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The 2010 edition of the Chinese Veterinary Drug Code only included erythromycin thiocyanate as a dosage form of soluble powder. Since the raw material of erythromycin thiocyanate is slightly soluble in water, and its preparation is unstable in an acidic environment or at room temperature, the potency will decrease. Gradually decreases

Method used

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  • Medicine composite containing erythromycin thiocyanate and preparation method thereof

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Effect test

Embodiment 1

[0030] The present embodiment provides a pharmaceutical composition containing erythromycin thiocyanate, comprising: erythromycin thiocyanate 5kg, sodium carbonate 3.5kg, sodium lauryl sulfate 2kg, 0.2kg poloxamer 188, polyethylene Pyrrolidone 5kg, anhydrous glucose 84.3kg.

[0031] This embodiment also provides the preparation method of the above-mentioned erythromycin thiocyanate-containing pharmaceutical composition, which comprises mixing sodium carbonate, sodium lauryl sulfate, poloxamer 188, polyvinylpyrrolidone and erythromycin thiocyanate according to the formula Mix evenly (mix for 20 minutes), crush and sieve through a 80-mesh sieve to obtain a semi-finished product; grind and sieve anhydrous glucose through an 80-mesh sieve according to the formula, and then put it into a mixing tank; Said semi-finished product, mixed evenly (mixed for 40 minutes), subpackaged to get.

Embodiment 2

[0033] The present embodiment provides a pharmaceutical composition containing erythromycin thiocyanate, comprising: erythromycin thiocyanate 10kg, sodium carbonate 5kg, citric acid 2.5kg, sodium lauryl sulfate 2kg, 0.5kg poloxamer 188, polyvinylpyrrolidone 7.5kg, anhydrous glucose 72.5kg.

[0034] This embodiment also provides the preparation method of the above-mentioned erythromycin thiocyanate-containing pharmaceutical composition, which comprises mixing sodium carbonate, citric acid, sodium lauryl sulfate, poloxamer 188, polyvinylpyrrolidone and thiocyanate according to the formula Erythromycin was mixed evenly (mixed for 20 minutes), crushed and sieved through an 80-mesh sieve to obtain a semi-finished product; after the anhydrous glucose was crushed and sieved through an 80-mesh sieve, it was dropped into a mixing tank; Add the semi-finished product in, mix evenly (mix 40 minutes), pack and get final product.

Embodiment 3

[0036] The present embodiment provides a pharmaceutical composition containing erythromycin thiocyanate, comprising: erythromycin thiocyanate 5kg, sodium carbonate 3.5kg, citric acid 2.5kg, sodium citrate 3kg, sodium lauryl sulfate 2kg, 0.2kg of poloxamer 188, 5kg of polyvinylpyrrolidone, 20kg of polyethylene glycol 4000, and 58.8kg of lactose.

[0037] This embodiment also provides the preparation method of the above-mentioned erythromycin thiocyanate-containing pharmaceutical composition, including sodium carbonate, citric acid, sodium citrate, sodium lauryl sulfate, poloxamer 188, polyvinylpyrrolidone Mix evenly with erythromycin thiocyanate (mixed for 20 minutes), crush and sieve through a 120-mesh sieve to obtain a semi-finished product; according to the formula, polyethylene glycol 4000 and lactose are crushed and sieved through a 100-mesh sieve, and then put into the mix In the tank; add the semi-finished product into the mixing tank, mix evenly (mixing for 25 minutes),...

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Abstract

The invention relates to a medicine composite containing erythromycin thiocyanate and a preparation method thereof. The composite comprises erythromycin thiocyanate, stabilizers, solubilizer and auxiliary materials. The preparation method includes the steps that the stabilizers, the solubilizer and erythromycin thiocyanate are evenly mixed, and the mixture is screened by a screen of 80-120 meshes in a smashed mode to obtain a semi-finished product; the auxiliary materials are screened by a screen of 80-100 meshes in a smashed mode to be thrown into a mixing tank; then the semi-finished product is added, even mixing is performed, and the medicine composite is obtained through sub-packaging. The approximate solubility of the medicine composite containing erythromycin thiocyanate in water is remarkably improved, stability is good, and through six months of acceleration tests, all detection items meet quality standards. The water solution of the medicine composite is not likely to be affected by temperature, water quality hardness and other objective factors, the content of effective components in drinking water can be kept unchanged for 24 hours, exertion of the medicine effect is guaranteed, and the effect of resisting gram-positive bacteria and mycoplasma infection is remarkably improved for livestock.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing erythromycin thiocyanate and a preparation method thereof, belonging to the technical application field of veterinary medicine. Background technique [0002] Erythromycin thiocyanate is a macrolide antibiotic and is the thiocyanate of erythromycin. Erythromycin is produced from the culture solution of the actinomycetes Streptomyceserythreus isolated from the soil on Panay Island, Philippines, and was first published by Eli Lilly in 1952. Several analogues such as erythromycin B and C are simultaneously produced in the culture medium, and they are removed by utilizing their differences in solubility to solvents. Erythromycin is white or light yellow-white crystalline powder, odorless, bitter in taste, hygroscopic in air, easily soluble in ethanol, chloroform, acetone and ether, etc., with low solubility in water, and increased solubility after salt formation. It is stable in a dry state,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K47/20A61K47/32A61P31/04
Inventor 徐峰孔祥强毛倩倩刘西锋邵耀东杨鑫
Owner QINGDAO KDN BIOTECH
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