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Drug meclofenoxate hydrochloride compound for adjusting nerve cell metabolism

A technology of meclofenoxate hydrochloride and nerve cells, which is applied in the field of medicine, can solve the problems of low bioavailability and high incidence of side reactions, and achieve the effects of improved fluidity, low moisture and impurity content, and good stability

Inactive Publication Date: 2015-12-09
QINGDAO HUAZHICAO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention also provides a composition preparation whose active ingredient is the meclofenoxate hydrochloride compound described in the present invention and a preparation method thereof. The preparation that can be prepared according to the content of the present invention maintains extremely high stability, which is obviously better than the commercially available variety, greatly improving the safety and effectiveness of meclofenoxate hydrochloride use, but its bioavailability is low and the incidence of side effects is high

Method used

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  • Drug meclofenoxate hydrochloride compound for adjusting nerve cell metabolism
  • Drug meclofenoxate hydrochloride compound for adjusting nerve cell metabolism
  • Drug meclofenoxate hydrochloride compound for adjusting nerve cell metabolism

Examples

Experimental program
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Effect test

Embodiment 1

[0019] Example 1: Preparation of Meclofenoxate Hydrochloride Crystalline Compound

[0020] (1) Add the crude product of meclofenoxate hydrochloride to a mixed solution of water and acetonitrile whose volume is 4 times the weight of meclofenoxate hydrochloride, the volume ratio of water and acetonitrile is 3:1, heat up to 30°C, and stir until completely dissolved;

[0021] (2) Under a sound field with a frequency of 30KHz and an output power of 45W, add a mixed solution of ether and cyclohexane whose volume is 8 times the weight of meclofenoxate hydrochloride while stirring. The volume ratio of ether and cyclohexane is 4 : 1, the stirring speed is 150 rev / min, and the adding speed is 100 ml / min;

[0022] (3) After adding the mixed solution of diethyl ether and cyclohexane, under a sound field with a frequency of 25KHz and an output power of 40W, cool down to -10°C at a rate of 10°C / hour, grow crystals for 2 hours, wash, and dry in vacuum to obtain Meclofenoxate hydrochlorid...

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Abstract

The invention relates to a drug meclofenoxate hydrochloride compound for adjusting nerve cell metabolism, belonging to the technical field of medicine. An x-ray powder diffraction pattern obtained by Cu-Kalpha ray measurement on the meclofenoxate hydrochloride compound is shown as picture 1. Compared with the prior art, the meclofenoxate hydrochloride crystal form compound is obviously improved in hygroscopicity and fluidity, extremely low in moisture and impurity content and better in stability, provides convenience for preparing a preparation, and is high in bioavailability and lower in side reaction rate.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a drug meclofenoxate hydrochloride compound for regulating nerve cell metabolism. Background technique [0002] The chemical name of meclofenoxate hydrochloride is 2-(dimethylamino)ethyl p-chlorophenoxy acetate hydrochloride, which is a central nervous system stimulant and brain neurotrophic drug, which can improve the central nervous system Functions, including causing awakening, invigorating the spirit, exciting breathing, improving nerve reflexes and increasing free activities, it can promote protein assimilation, and can be used as raw materials for the synthesis of choline and acetylcholine in the body, and then synthesize lecithin, thereby changing the neurotransmitter of the central nervous system content, increase the amount of acetylcholine in the brain, have an anti-hypoxic effect, promote the oxidation-reduction reaction of brain cells, promote brain energy metabolism, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C219/06C07C213/10
Inventor 刘学键
Owner QINGDAO HUAZHICAO PHARMA CO LTD
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