A kind of water-soluble o-hydroxyethyl chitosan nanoparticles and its preparation method and application

A technology of hydroxyethyl chitosan and nanoparticles, which is applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, powder delivery, etc., can solve problems such as difficult entry into cells and large size, and achieve increased action time and size. control and increase solubility

Active Publication Date: 2017-10-03
INST OF CHEM CHINESE ACAD OF SCI +1
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, the chitosan nanoparticles prepared by the above method are often large in size and difficult to enter cells.

Method used

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  • A kind of water-soluble o-hydroxyethyl chitosan nanoparticles and its preparation method and application
  • A kind of water-soluble o-hydroxyethyl chitosan nanoparticles and its preparation method and application
  • A kind of water-soluble o-hydroxyethyl chitosan nanoparticles and its preparation method and application

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Embodiment 1

[0060] Embodiment 1, preparation and application test of water-soluble O-hydroxyethyl chitosan nanoparticles

[0061] 1. Preparation

[0062] as per figure 1 The reaction equation shown was carried out to prepare water-soluble O-hydroxyethyl chitosan.

[0063] (1) The preparation method of water-soluble O-hydroxyethyl chitosan

[0064] Take 1.5g of chitosan (abbreviated as CS), dissolve it in 150ml of 8% acetic acid aqueous solution by volume fraction, stir until completely dissolved, transfer the chitosan acetic acid aqueous solution to a three-necked flask; add 0.12g of sodium perborate, and control the temperature at 60°C , high-speed stirring, after reacting for 5 hours, add sodium hydroxide solution to adjust the pH value of the reaction system to 10-12, control the temperature at 4-5°C, add 10ml of ethylene oxide to the reaction system in several times, at a rate of 8-15°C / h Raise the temperature to 60°C, continue to control the temperature at 60°C, stir at 1200-1500r...

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Abstract

The invention discloses water-soluble O-hydroxyethyl chitosan nanoparticles as well as a preparation method and application thereof. The preparation method comprises the following steps: 1), carrying out oxidative degradation on chitosan in an acidic aqueous solution, adjusting the pH value of the system, adding ethylene oxide, and carrying out ethoxyl etherification I so as to obtain an O-hydroxyethyl chitosan aqueous solution; 2), mixing the O-hydroxyethyl chitosan aqueous solution with a D-alpha-tocopherol succinate solution, and carrying out covalent linkage reaction so as to obtain an aqueous solution of chitosan derivative nanoparticles; 3), mixing the aqueous solution of chitosan derivative nanoparticles with ethylene oxide and carrying out ethoxyl etherification II so as to obtain the water-soluble O-hydroxyethyl chitosan nanoparticles. The prepared water-soluble O-hydroxyethyl chitosan nanoparticles have good water solubility, are relatively small in particle size and controllable in size and have good biocompatibility and anticancer selectivity; when the water-soluble O-hydroxyethyl chitosan nanoparticles are used as drug carriers, the solubility of drugs is increased and bioavailability of the drugs is improved.

Description

technical field [0001] The invention relates to a water-soluble O-hydroxyethyl chitosan nano particle and a preparation method and application thereof, belonging to the field of biomedicine. Background technique [0002] Chitosan [β-(1-4)-2-amino-2-deoxy-D-glucose] is a positive amino polysaccharide existing in the biological world, which is obtained by hydrolyzing and deacetylating chitin under alkaline conditions. There are a large number of free amino groups and hydroxyl groups on the chitosan molecule, so it not only has good moisture retention and moisturizing properties, but also can expand the application range of chitosan by functional modification; in addition, it also has Non-biological toxicity, good film-forming properties, biodegradability and good biocompatibility, etc., in recent years, chitosan has been widely used in health food, food preservation, cosmetics, biomedicine, plant disease prevention and other fields. its unique application value. [0003] How...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/08C08J3/12A61K9/14A61K47/36A61P35/00
Inventor 刘扬李虹杜立波肇玉明张晓洁
Owner INST OF CHEM CHINESE ACAD OF SCI
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