Supercharge Your Innovation With Domain-Expert AI Agents!

A kind of lercanidipine hydrochloride tablet and preparation method thereof

A technology of lercanidipine hydrochloride and lercadipine hydrochloride, which is applied in the direction of sugar-coated pills, pill delivery, cardiovascular system diseases, etc., can solve the problems of lercanidipine hydrochloride yield and dissolution rate to be improved, high cost of raw materials, etc., to achieve dissolution High yield, high yield, and feasible preparation process

Active Publication Date: 2018-06-26
JIANGSU FUBANG PHARMA
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The raw material cost of the existing lercanidipine hydrochloride tablet preparation process is relatively high, and the yield and dissolution rate of lercanidipine hydrochloride in the tablet need to be improved

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of lercanidipine hydrochloride tablet and preparation method thereof
  • A kind of lercanidipine hydrochloride tablet and preparation method thereof
  • A kind of lercanidipine hydrochloride tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Prescription 1

[0021]

[0022]

[0023] The preparation process is as follows:

[0024] (1) Pulverize the raw material of lercanidipine hydrochloride, pass through a 100 mesh sieve, pass lactose, microcrystalline cellulose, and sodium carboxymethyl starch respectively through an 80 mesh sieve, dissolve povidone K30 in purified water, and make a mass fraction of 5% povidone K30 solution;

[0025] (2) 10g of lercanidipine hydrochloride and 70g of lactose were mixed uniformly by the method of equal increments, then 29g of microcrystalline cellulose and 8g of sodium carboxymethyl starch were added, placed in a mixer and mixed uniformly;

[0026] (3) Transfer the mixed powder into a swinging granulator, use 0.8g, 5% povidone K30 to make a soft material, pass through a 30-mesh sieve for granulation, and dry at 50°C;

[0027] (4) passing the dry granules through a 30-mesh sieve for granulation, adding 0.7g of magnesium stearate, and mixing uniformly to obtain an inte...

Embodiment 2

[0032] Prescription 2

[0033]

[0034] The preparation process is as follows:

[0035] (1) Pulverize the raw material of lercanidipine hydrochloride, pass through a 100 mesh sieve, pass lactose, microcrystalline cellulose, and sodium carboxymethyl starch respectively through an 80 mesh sieve, dissolve povidone K30 in purified water, and make a mass fraction of 5% povidone K30 solution;

[0036] (2) 10g of lercanidipine hydrochloride and 72g of lactose were mixed uniformly by the method of equal increments, then 31g of microcrystalline cellulose and 9g of sodium carboxymethyl starch were added, placed in a mixer and mixed uniformly;

[0037] (3) Transfer the mixed powder into a swinging granulator, use 1g, 5% povidone K30 to make a soft material, pass through a 30-mesh sieve to granulate, and dry at 50°C;

[0038] (4) passing the dry granules through a 40-mesh sieve for granulation, adding 0.8g of magnesium stearate, and mixing uniformly to obtain an intermediate;

[003...

Embodiment 3

[0043] Prescription 3

[0044]

[0045] The preparation process is as follows:

[0046] (1) Pulverize the raw material of lercanidipine hydrochloride, pass through a 100 mesh sieve, pass lactose, microcrystalline cellulose, and sodium carboxymethyl starch respectively through an 80 mesh sieve, dissolve povidone K30 in purified water, and make a mass fraction of 5% povidone K30 solution;

[0047] (2) 10g of lercanidipine hydrochloride and 73.5g of lactose were mixed uniformly by the method of equal increments, then 31.5g of microcrystalline cellulose and 10g of sodium carboxymethyl starch were added, placed in a mixer and mixed uniformly;

[0048] (3) Transfer the mixed powder into a swinging granulator, use 1.1g, 5% povidone K30 to make a soft material, pass through a 30-mesh sieve to granulate, and dry at 50°C;

[0049] (4) Pass the dry granules through a 50-mesh sieve for granulation, add 1g of magnesium stearate, and mix uniformly to obtain an intermediate;

[0050] (...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses lercanidipine hydrochloride tablets. The lercanidipine hydrochloride tablets comprise lercanidipine hydrochloride, lactose, microcrystalline cellulose, carboxymethyl starch sodium, 5% povidone K30 solution and magnesium stearate, wherein the weight ratio of the lercanidipine hydrochloride, lactose, microcrystalline cellulose, carboxymethyl starch sodium, 5% povidone K30 solution and magnesium stearate is 10:70-75:29-33:8-12:0.8-1.2:0.7-3. The invention further provides a preparation method of the lercanidipine hydrochloride tablets. The method includes: the lercanidipine hydrochloride is mixed with the lactose and the like in an equal-quantity increasing manner and then evenly mixed with other auxiliary materials. The lercanidipine hydrochloride tablets have the advantages that the raw materials and auxiliary materials are evenly mixed, the tablets are even in lercanidipine hydrochloride content and high in dissolution rate, in vivo absorption is benefited, and the bioavailability of the tablets is increased.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a lercanidipine hydrochloride tablet and a preparation method thereof. Background technique [0002] Hypertension is a disease caused by many factors. Long-term hypertension can cause various complications, such as stroke, congestive heart failure, ischemic heart disease, and kidney failure. Experiments have proved that persistent high blood pressure can cause coronary artery sclerosis and cardiac hypertrophy, which will later produce myocardial ischemia, angina pectoris, myocardial infarction and re-infarction. The high morbidity, high disability and high death rate of hypertension in China make the control of hypertension a great challenge. Combined with the high proportion of isolated systolic hypertension and high-salt eating habits in Chinese hypertensive patients, there is no shortage of calcium ion antagonists in the treatment of such hypertensive patients. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/28A61K31/4422A61K47/26A61P9/12
Inventor 姜和平黄金友何林受车红俊
Owner JIANGSU FUBANG PHARMA
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com