Preparation method and medical application of blood-fat-reducing active component

An active ingredient and blood lipid-lowering technology, applied in the field of active ingredients of Acanthopanax

Inactive Publication Date: 2015-12-30
BEIHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention is the first time to isolate the active component that inhibits DGAT1 from Acanthopanax. After many pharmacological experiments, it is found that the active c

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Soak Acanthopanax 1-2 times the amount of 75% ethanol for 1 hour, use ultrasonic extraction for 1-3 hours, filter and collect the filtrate; the filtrate is concentrated with a rotary evaporator, collect the concentrate, let it cool, and add 2-3 times Measure the water and stir, let it stand at room temperature for 24 hours, precipitate out, filter or centrifuge to get the precipitate, heat the precipitate in a watch glass, remove ethanol and water, until there is no alcohol smell, that is, the alcoholic extract of Acanthopanax senticosus; The ethanol extract was subjected to 150 μm reversed-phase chromatography, and methanol / water (V / V, 0:10-10:0) was used as the mobile phase for gradient elution, and the collected separated components were detected by reversed-phase thin-layer chromatography. Fractions with the same composition were combined and concentrated to obtain 10 fractions (F1-F10). The F2 component was then subjected to HP-20 macroporous chromatography, using ...

Embodiment 2

[0042] According to the conventional method of pharmacy, the active component prepared in Example 1 can be dried, mixed with one or more pharmaceutically acceptable carriers or excipients, and prepared into various kinds suitable for gastrointestinal administration. Various conventional dosage forms of medicines. For example, the dry powder prepared above is aseptically filled into capsules according to conventional methods to obtain the active ingredient drug of the present invention in capsule dosage form. The active ingredient of the present invention may be formulated into tablets, capsules, pills, powders, suppositories and solutions and suspensions according to methods known in the pharmaceutical industry. Among them, capsules and tablets suitable for gastrointestinal administration are preferred. When preparing dosage forms suitable for oral administration, sucrose, lactose, galactose, corn starch, gelatin, microcrystalline cellulose, carboxymethyl cellulose, etc. can ...

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Abstract

The invention relates to the field of medical technologies, in particular to a preparation method and medical application of a blood-fat-reducing active component. The active component is a component which is obtained from eleutherococcus senticosus serving as an araliaceae acanthopanax plant in an extracted and separated mode and restrains activity of diacylglycerol acyltransferase (DGAT1). Repeated in-vitro DGAT1 restraining experiments show that the component has obvious DGAT1 restraining activity, can be applied to preparing medicine for preventing and treating hyperlipidemia, atherosclerosis, obesity and complications and has important meaning for developing and utilizing medicinal plant resources in China.

Description

technical field [0001] The invention relates to an active component of Acanthopanax senticosus for treating hyperlipidemia, discloses the active component with hypolipidemic effect and an extraction method, and also provides its medical application. The active component of the present invention has been tested by diacylglycerol acyltransferase 1 (DiacylgycerolAcyltransferase, DGAT1) many times in vitro. and complication medicines, involving the technical field of traditional Chinese medicine. Background technique [0002] Hyperlipidemia mainly refers to a series of serious harms caused by high serum total cholesterol (TC) or triacylglycerol (TG) levels and / or low serum high-density lipoprotein-cholesterol (HDL-C) levels Diseases of human health. Along with the raising of people's living standard, the change of lifestyle, the arrival of population aging, the crowd suffering from hyperlipidemia is constantly increasing. Studies have shown that hyperlipidemia is the culprit ...

Claims

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Application Information

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IPC IPC(8): A61K36/254A61P3/06A61P9/10A61P3/04
Inventor 崔龙脱振东李娜邢姗姗李佳琳王喜斌
Owner BEIHUA UNIV
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