Novel polymer medicine for treating cancers

Abstract

The invention discloses a novel polymer medicine for treating cancers. According to the novel polymer medicine, acrylamide is polymerized by utilizing an atom transfer radical polymerization method, so as to obtain polyacrylamide; the polyacrylamide is modified by utilizing folate molecules; lysine benzyl ester carboxylic acid anhydride is polymerized by utilizing an ring-opening polymerization method, so as to obtain polylysine benzyl ester; the polylysine benzyl ester is grafted with doxorubicin through hydrazone bonds; the polyacrylamide and the polylysine benzyl ester are bonded by utilizing a click chemistry method, so as to obtain segmented copolymers; the segmented copolymers are respectively dissolved in tetrahydrofuran and are then transferred to a dialysis bag for dialysis with pure water, and dialysate is filtered through a filter membrane; a filtered solution is freeze-dried, so as to obtain medicine carrying micelle. The carrier micelle of the medicine is of a core-shell double-layer structure, an outer layer is prepared from the hydrophilic polyacrylamide, and an inner layer is prepared from a medicine molecule wrapping layer. The material has the following advantages that the material belongs to nanoparticles; targeting delivery of the medicine to cancer cells and pH sensitivity release of the medicine in the cancer cells can be realized; the medicine carrying capacity is large; the stability is good; the toxic and side effects of the medicine on normal tissues and organs can be effectively reduced through targeting functions.

Description

Technical field [0001] The invention relates to a new type of macromolecule drug for cancer treatment, in particular to a preparation method of a block polymer material drug carrier micelle with cancer cell targeting. The invention belongs to the field of polymer chemistry and polymer technology. Background technique [0002] Cancer has become the most important disease that endangers human health. One of the important methods to treat cancer is drug therapy. However, many anticancer drugs have defects such as insoluble in water and poor stability. For example, camptothecin, paclitaxel, doxorubicin, 5-fluorouracil, etc. are difficult to be well utilized by organisms due to their poor solubility. Solving the problem of their water solubility is the key to the clinical application of these pharmaceutical preparations. In addition, most of the tumor treatment and diagnostic drugs have non-selective effects, and are often distributed in some normal tissues and organs, and the t...

AI Technical Summary

Problems solved by technology

[0006] However, due to the complex structure of the polymer in the star polymer, the prepared drug carrier has problems such as poor biocompatibility, decreased drug loading capacity, and reduced water solubility of drug molecules on the surface of dendrimer.

In addition, dendrimer has a complex structure and high synthesis cost

These problems limit the application of star-shaped polymer nano-drug delivery system

Images