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A kind of degradable bioactive porous ceramic material, preparation method and application thereof

A porous ceramic and biologically active technology, applied in prosthetics, medical science, etc., can solve the problems of poor mechanical strength and slow degradation of porous materials, and achieve the effects of promoting proliferation, shortening acute inflammatory reactions, and accelerating efficiency and progress

Active Publication Date: 2018-08-07
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

On the other hand, widely studied and clinically applied phosphate ceramics such as apatite, tricalcium phosphate, and their composite dual-phase ceramics have good osteoconductivity, but their degradation is slow, and the mechanical strength of their porous materials is extremely poor.

Method used

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  • A kind of degradable bioactive porous ceramic material, preparation method and application thereof
  • A kind of degradable bioactive porous ceramic material, preparation method and application thereof
  • A kind of degradable bioactive porous ceramic material, preparation method and application thereof

Examples

Experimental program
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Embodiment 1

[0049] 1) Add 500mL of 0.40mol / L Ca(NO 3 ) 2 , 0.04mol / L Mg(NO 3 ) 2 The pH value of the aqueous solution was adjusted to 10.0 with ammonia water, and then the solution was added dropwise to a volume of 500mL of 0.44mol / LNa 2 SiO 3 In the aqueous solution, continue to stir for 8 hours after the dropwise addition, then filter the reaction sediment, wash with deionized water for 3 times, then wash with absolute ethanol once, dry at 120°C, and calcined at 850°C for 3 hours , and then ball milled for 4 hours to obtain a magnesium-doped powder with a particle size of 0.5-3 μm. Tested by X-ray diffraction (as attached figure 1 As shown), it is proved that the powder phase is pure β-calcium silicate, and the mass content of magnesium in the powder is 2.1% through atomic absorption spectroscopic analysis.

[0050] 2) Add 500mL of 0.60mol / L Ca(NO 3 ) 2 The pH value of the aqueous solution was adjusted to 7.5 with aqueous ammonia, and then the solution was added dropwise to a 0....

Embodiment 2

[0053] 1) Add 500mL of 0.40mol / L Ca(NO 3 ) 2 , 0.057mol / L MgCl 2 The pH value of the aqueous solution was adjusted to 9.0 with aqueous ammonia, and then the solution was added dropwise to a volume of 500 mL of 0.457 mol / L Na 2 SiO 3 In the aqueous solution, continue to stir for 12 hours after the dropwise addition, then filter the reaction sediment, wash with deionized water for 3 times, then wash with absolute ethanol once, dry at 120°C, and calcined at 1200°C for 1 hour , and then ball milled for 6 hours to obtain magnesium-doped wollastonite-false wollastonite composite powder with a particle size of 0.5-2 μm. According to atomic absorption spectroscopic analysis and test, the mass content of magnesium in the powder is 3.0%.

[0054] 2) 500mL of 0.50mol / L CaCl 2 The pH value of the aqueous solution was adjusted to 10.5 with ammonia water, and then the solution was added dropwise to a volume of 500 mL, and the pH value was adjusted to 0.30mol / L (NH 4 ) 3 PO 4 In the ...

Embodiment 3

[0057] 1) Add 500mL of 0.50mol / L Ca(NO 3 ) 2 , 0.001mol / L Mg(NO 3 ) 2 The pH value of the aqueous solution was adjusted to 11.0 with aqueous ammonia, and then the solution was added dropwise to a volume of 500 mL of 0.501 mol / LNa 2 SiO 3 In the aqueous solution, continue to stir for 9 hours after the dropwise addition, then filter the reaction sediment, wash with deionized water for 3 times, then wash with absolute ethanol once, dry at 120°C, and calcined at 1250°C for 2 hours , and then ball milled for 4 hours to obtain magnesium-doped pseudo-wollastonite powder with a particle size of 0.8-4 μm. According to atomic absorption spectroscopic analysis and test, the mass content of magnesium in the powder is 0.2%.

[0058] 2) 500mL of 0.50mol / L Ca(NO 3 ) 2 The pH value of the aqueous solution was adjusted to 10.5 with ammonia water, and then the solution was added dropwise to a volume of 500 mL, and the pH value was adjusted to 0.38mol / L (NH 4 ) 3 PO 4 In the aqueous so...

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Abstract

The invention discloses a degradable bioactive porous ceramic material, a preparation method and an application thereof. The porous ceramic material includes calcium magnesium silicate and calcium phosphate, wherein the calcium magnesium silicate is 40 to 98% by weight, and the calcium magnesium silicate is silica fume with a magnesium weight percentage of 0.2 to 3.0%. Stone or pseudowollastonite, calcium phosphate is tricalcium phosphate, apatite, or a complex of the two. The preparation is obtained by compounding the synthesized calcium magnesium silicate and calcium phosphate powders, and then processing them through additive manufacturing and sintering. The porous ceramic material in the present invention can perform bone induction and conduction regeneration repair for bone defects involved in plastic surgery, maxillofacial surgery, brain surgery, stomatology, orthopedics or ophthalmology, and also has application value in bone reconstruction of large limb bone defects .

Description

technical field [0001] The invention relates to biomedical materials, in particular to a bioactive ceramic porous material for promoting regeneration and repair of bone defects, a preparation method and application. Background technique [0002] The regenerative repair of bone loss caused by mechanical shock, lesions and other surgical needs is a research hotspot and difficult problem in the field of biomedical materials. The shape, thickness, and stress load level of bones in various parts of the human body are not the same, and the efficiency of bone damage repair under different ages and pathological conditions is also not completely the same. For a long time, humans have mainly relied on autologous bone, allogeneic bone, animal bone, or metals, alloys, or highly stable inert ceramics, and polymer materials with high mechanical load-bearing capacity to repair, fill, and replace human bone defects. . Although bone has a good self-regeneration ability, the bone filled wit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/10A61L27/56A61L27/50C04B35/22C04B35/447C04B35/622
Inventor 苟中入贺永邵惠锋杨贤燕何冬霜
Owner ZHEJIANG UNIV