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Continuous chromatographic separation and purification system for separating sugar in inulin

A continuous chromatography, separation and purification technology, applied in the field of liquid separation and purification, can solve the problems of low resin utilization efficiency, low resin utilization rate, large discharge of acid-base waste liquid, etc., achieve good separation and purification effect, improve production efficiency, improve Effect of Utilization and Process Yield

Active Publication Date: 2015-12-30
YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] When the fixed bed intermittently separates fructo-oligosaccharides and polyfructosaccharides, only a small amount of resin in the mass transfer area is working in the entire bed, and most of the resin is in an inactive idle and waiting state, which has the disadvantage of low utilization rate of the resin; at the same time A large amount of material or regenerant needs to pass through or soak the deactivated resin, causing pollution to the resin
In addition, the operation period is long, there are many connected pipelines and valves, and the operation is cumbersome; the resin utilization efficiency is low, resulting in a large resin bed and a large amount of washing water required for the separation process; not only the area is large, but the product purity, concentration and yield Low, and the discharge of acid and alkali waste liquid is large, which seriously pollutes the environment

Method used

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  • Continuous chromatographic separation and purification system for separating sugar in inulin
  • Continuous chromatographic separation and purification system for separating sugar in inulin
  • Continuous chromatographic separation and purification system for separating sugar in inulin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A. Prepare 10L of 100g / L inulin solution, connect the instrument according to the operating rules, connect 75L pure water to zone 1, and connect 5L pure water to zone 2 and zone 3;

[0040] B. Set the experimental parameters of the panel and pump flow, press the "turntable origin" button at the same time, clear the time, and set the feeding flow rate of the peristaltic pump to 5ml / min;

[0041] location

Set flow rate (ml / min)

Exit 1 (District 1)

60

Exit 6 (District 2)

44

Exit 11 (District 3)

49

Exit 16 (District 4)

40

[0042] C. Turn on the switch of the pump, press the "Turntable Start" button, and then ensure that the instrument runs normally without leakage;

[0043] D. Samples were taken after 24 hours of experiment operation, and the samples taken were analyzed on the TLC plate. image 3 2nd and 3rd TLC results.

Embodiment 2

[0045] A. Prepare 10L of 200g / L inulin solution, connect the instrument according to the flow chart, connect 75L pure water to zone 1, and connect 5L pure water to zone 2 and zone 3;

[0046] B. Set the experimental parameters of the panel and pump flow, press the "turntable origin" button at the same time, clear the time, and set the feeding flow rate of the peristaltic pump to 4ml / min

[0047] location

Set flow rate (ml / min)

Exit 1 (District 1)

50

Exit 6 (District 2)

42

Exit 11 (District 3)

46

Exit 16 (District 4)

36

[0048] C. Turn on the switch of the pump, press the "Turntable Start" button, and then ensure that the instrument runs normally without leakage;

[0049] D. Samples were taken after 24 hours of experiment operation, and the samples taken were analyzed on the TLC plate. image 3 4th and 5th TLC results.

Embodiment 3

[0051] A. Prepare 10L of 200g / L inulin solution, connect the instrument according to the flow chart, connect 75L pure water to zone 1, and connect 5L pure water to zone 2 and zone 3;

[0052] B. Set the experimental parameters of the panel and pump flow, press the "turntable origin" button at the same time, clear the time, and set the feeding flow rate of the peristaltic pump to 5ml / min;

[0053] location

Set flow rate (ml / min)

Exit 1 (District 1)

50

Exit 6 (District 2)

39

Exit 11 (District 3)

44

Exit 16 (District 4)

40

[0054] C. Turn on the switch of the pump, press the "Turntable Start" button, and then ensure that the instrument runs normally without leakage;

[0055] D. Samples were taken after 24 hours of experiment operation, and the samples taken were analyzed on the TLC plate. image 3 The results of the 7th and 6th thin-layer chromatography.

[0056] see image 3 For each strip from left to right: 1s...

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Abstract

The invention provides a continuous chromatographic separation and purification system for separating sugar in inulin. A plurality of separation units which are connected together in series are driven by a turntable to rotate, and when the turntable rotates a circle, under the action of cation exchange resin filled in the separation units, fructo-oligosaccharide flows out of an elution area, polyfructose flows out of a separation area, and recycled water flows out of a concentration area. In such a manner, an inulin solution is separated and purified, so that links of exchange, washing, recycling, leaching and the like in an original fixed bed are integrated in the same system to achieve a better separation and purification effect.

Description

technical field [0001] The invention relates to the technical field of liquid separation and purification, in particular to a continuous chromatographic separation and purification system for separating sugar in inulin. Background technique [0002] Inulin is a fructan mixture in which fructose molecules are connected by β-(2-1) glycosidic bonds and end with a glucose molecule. Currently, inulin is mainly derived from Jerusalem artichoke and chicory. The degree of polymerization of fructose units in natural inulin is usually 2-60, with an average degree of polymerization of about 10. [0003] Fructans with a polymerization degree of 2-9 in inulin are commonly called fructo-oligosaccharides, and the content of fructo-oligosaccharides in inulin is generally 5-35%. Fructose-oligosaccharide is a natural active substance, a new type of sweetener with health functions such as regulating intestinal flora, multiplying bifidobacteria, maintaining the balance of intestinal flora, pr...

Claims

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Application Information

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IPC IPC(8): B01D15/04
Inventor 李莉莉秦松张银焦绪栋崔玉琳
Owner YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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