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Compound oral membrane containing sodium azulene sulfonate and preparation method

A technology of sodium azulene sulfonate and oral film, which is applied in the field of compound oral film containing sodium azulene sulfonate and its preparation, which can solve problems such as difficulty in ensuring curative effect and inability to fix the powder, achieve good therapeutic effect and prolong drug action time , the effect of drug concentration concentration

Active Publication Date: 2016-01-06
天津顶硕药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the relatively soft mucous membrane in the oral cavity and frequent exercise, the powder cannot be fixed on the ulcer, so it is difficult to guarantee the curative effect; the compound preparation has a definite curative effect, but it also has its own shortcomings.

Method used

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  • Compound oral membrane containing sodium azulene sulfonate and preparation method
  • Compound oral membrane containing sodium azulene sulfonate and preparation method
  • Compound oral membrane containing sodium azulene sulfonate and preparation method

Examples

Experimental program
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Effect test

preparation example Construction

[0021] The preparation method of the compound oral film containing sodium azulene sulfonate of the present invention comprises the following steps:

[0022] 1) Select PVA05882-4%, PVA17881-2%, hyaluronic acid chitosan 3-6%, sodium carboxymethylcellulose 2-5%, Tween-801-3%, Tween-600.5-2 %, Glycerin 6-10%, 55-70%, 10:1 Radix Radix Radix Extract 5-8%, Vitamin B2 2-5%, Sodium Azulene Sulfonate 1-4%;

[0023] 2) Mix PVA0588, PVA1788, hyaluronic acid-like chitosan and distilled water in step 1), heat and dissolve in a water bath to obtain a solution, wherein the heating temperature is 80°C±5°C, and the time is 30min;

[0024] 3) Mix sodium carboxymethylcellulose, Tween-80, Tween-60 and glycerin in step 1), stir into a paste and add to the solution obtained in step 1);

[0025] 4) Take the Radix isatidis extract, vitamin B2 and sodium azulene sulfonate in step 1) and add it to the solution obtained in step 2), stir until all the components are dissolved, keep warm and degas to obta...

Embodiment 1

[0028] Embodiment 1 (dosing is 250g)

[0029] 1) Select:

[0030]

[0031] 2) Mix PVA0588, PVA1788, hyaluronic acid-like chitosan and distilled water in step 1), heat and dissolve in a water bath to obtain a solution, wherein the heating temperature is 80°C±5°C, and the time is 30min;

[0032] 3) Mix sodium carboxymethylcellulose, Tween-80, Tween-60 and glycerin in step 1), stir into a paste and add to the solution obtained in step 1);

[0033] 4) Take the Radix isatidis extract, vitamin B2 and sodium azulene sulfonate in step 1) and add it to the solution obtained in step 2), stir until all the components are dissolved, keep warm and degas to obtain the medicinal solution;

[0034] 5) Pour the medicinal liquid onto a chopping board coated with sterile liquid paraffin, scrape the medicinal liquid with a sterilized scraper, and the thickness of the medicinal liquid is 0.2mm;

[0035] 6) Vacuum-dry at 35°C for 2.5 hours to form a film, and then use a special film cutting de...

Embodiment 2

[0036] Embodiment 2 (dosing is 250g)

[0037] 1) Select:

[0038]

[0039]2) Mix PVA0588, PVA1788, hyaluronic acid-like chitosan and distilled water in step 1), heat and dissolve in a water bath to obtain a solution, wherein the heating temperature is 80°C±5°C, and the time is 30min;

[0040] 3) Mix sodium carboxymethylcellulose, Tween-80, Tween-60 and glycerin in step 1), stir into a paste and add to the solution obtained in step 1);

[0041] 4) Take the Radix isatidis extract, vitamin B2 and sodium azulene sulfonate in step 1) and add it to the solution obtained in step 2), stir until all the components are dissolved, keep warm and degas to obtain the medicinal solution;

[0042] 5) Pour the medicinal liquid onto a chopping board coated with sterile liquid paraffin, scrape the medicinal liquid with a sterilized scraper, and the thickness of the medicinal liquid is 0.22 mm;

[0043] 6) Vacuum-dry at 35°C for 2 hours to form a film, and then use a special film cutting dev...

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Abstract

The invention discloses a compound oral membrane containing sodium azulene sulfonate and a preparation method. The oral membrane comprises components in percentage by weight as follows: 2%-4% of PVA0588, 1%-2% of PVA1788, 3%-6% of hyaluronic-acid-like chitosan, 2%-5% of sodium carboxymethyl cellulose, 1%-3% of Tween-80, 0.5%-2% of Tween-60, 6%-10% of glycerin, 55%-70% of distilled water, 5%-8% of a 10:1 isatis root extract, 2%-5% of vitamin B2 and 1%-4% of sodium azulene sulfonate. The oral membrane can prolong the drug acting time, has the good curative effect on targeted parts, can take effect for a longer time, can promote body recovery and enhancement of immunity and resistance, is beneficial repair of oral ulcer mucosae and has a good treatment effect on oral ulcers. Selected materials are also applied to food, wide in source and lower in product, and the product is low in preparation cost, safe to use and wider in market application range and has higher promotional value.

Description

technical field [0001] The invention relates to a compound oral film. In particular, it relates to a compound oral film containing sodium azulene sulfonate for treating oral ulcers caused by various reasons and a preparation method thereof. Background technique [0002] Oral mucosal ulcer is a common disease with the highest incidence rate among oral mucosal diseases. It is mostly round or oval in shape. Mucous membranes, surrounded by a red halo around the ulcer. The surface is covered with a yellow pseudomembrane. Patients feel pain, and the incidence rate is high. The etiology of recurrent oral mucosal ulcers is still unclear, and may be related to the following factors: 1. Digestive system diseases and dysfunction, such as abdominal distension, diarrhea or constipation. 2. Endocrine changes, some female patients often occur during the menstrual period, which may be related to the decline in the amount of estrogen in the body. 3. Mental factors. Some patients suffer ...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K36/195A61K36/315A61K31/185A61K47/38A61P1/02A61K31/525
Inventor 许荧蔡春梅
Owner 天津顶硕药业股份有限公司
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