Preparation method of magnetic granules for targeting therapy of tumor
A magnetic particle and tumor-targeting technology, applied in the field of medical materials, can solve the problems of unsafe reduction of "particle agglomeration, negative effects of polymer viscosity, unfavorable drug combination and adhesion, etc., to save time and cost, reduce production cost, performance improvement
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Embodiment 1
[0027] (1) Weigh 2 moles of NaOH and dissolve it in deoxygenated pure water to form a 1.0mol / L solution. After heating to 60°C, add 40g of soluble starch and stir until it is completely gelatinized to form a mixed solution; add the mixed solution Into the reactor, seal the reactor, and use high-purity nitrogen to purge the reactor through the inlet valve to exhaust the internal air; as the soluble starch is added to the hot NaOH solution to undergo a gelatinization reaction, the starch molecules in the granules extend in all directions Diffusing and dissolving out of the particles, the expanded starch molecules will be connected and entangled with each other to form a network of hydrocolloid. When starch enters the granular disintegration stage of the gelatinization reaction, the viscosity of the solution is the largest, so that the starch molecules can be coated around NaOH, which inhibits the reaction speed of NaOH with iron and ferrous ions, and inhibits the Fe generated by t...
Embodiment 2
[0034] (1) Weigh 8 moles of NaOH and dissolve it in deoxygenated pure water to form a 1.5 mol / L solution, add 120 g of water-soluble starch, and stir at room temperature until it is completely dissolved; form a mixed liquid; add the mixed liquid to the reactor In, the reactor is sealed, and high-purity nitrogen is used to purge the reactor through the inlet valve to exhaust the internal air;
[0035] (2) Weigh 1.2 moles of FeCl 3 ·6H 2 O, 1 mole FeCl 2 ·4H 2 O is dissolved in deoxygenated pure water to form a mixed solution; its concentration is 1.2 mol Fe per liter of solution 3+ And 1.0molFe 2+ .
[0036] (3) Add dropwise the mixed solution obtained in step (2) to the sodium hydroxide starch gelatinized solution obtained in step (1) through the feed valve. The ratio of the raw materials added is the molar ratio OH — : Fe 3+ : Fe 2+ =8:1.2:1, heat the reaction kettle to 200℃, keep it for 8h, after natural cooling, wash and dry to obtain carbon-coated nano-magnetic Fe 3 O 4 .
[003...
Embodiment 3
[0039] (1) First, weigh 8 moles of NaOH and dissolve it in deoxygenated pure water to form a 1.2mol / L solution. Add 80g of pregelatinized starch at 40°C and stir until it is completely dissolved; ultrasonically mix at a frequency of 200Hz. The air bubbles existing in the mixed solution are vibrated under the action of sound waves, and when they reach a certain limit, they grow and collapse to play a cavitation effect. Using ultrasonic cavitation, the NaOH and the starch molecules in the solution are uniformly mixed and the starch particle size is controlled. evenly distributed. Add the mixed liquid to the reaction kettle, seal the reaction kettle, and use high-purity nitrogen to purge the reaction kettle through the inlet valve to exhaust the internal air;
[0040] (2) Weigh 1.5 moles of FeCl 3 ·6H 2 O, 1 mole FeCl 2 ·4H 2 O is dissolved in deoxygenated pure water to form a mixed solution; its concentration is 1.5 mol Fe per liter of solution 3+ And 1.0molFe 2+ .
[0041] (3) Add ...
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