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A kind of preparation method of lotus leaf extract

A technology of lotus leaf and nuciferine, applied in the field of natural plant extracts, can solve the problems of low product content, unsuitable for industrialization, expensive equipment, etc., and achieve high yield, excellent separation effect and low cost

Active Publication Date: 2017-10-03
内蒙古昶辉生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above several methods are not only complicated to operate, expensive in equipment, but also low in product content, poor in quality or unsuitable for industrialization, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Take 5kg of lotus leaves, chop them into thin strips, add sea salt water, infiltrate and pile up for 0.5h; move to the extraction tank, add water twice the weight of the raw materials, add snail enzyme and 0.5% of the weight of lotus leaf raw materials according to 1% of the water amount Vitamin C, stirred and extracted at room temperature for 2 hours, filtered to obtain the extract; the extract was directly loaded, separated through a neutral alumina column, the mobile phase was 3% phosphoric acid solution-ethanol (1:1), and the eluate was collected; The eluent is separated by simulated moving bed chromatography, wherein the adsorbent filled in the simulated moving bed chromatography is silica gel, and the eluent is 0.1% triethylamine aqueous solution; the flow rate in the adsorption zone is 2BV / h; the flow rate in the elution zone is 3BV / h; The time is 700s; the temperature is controlled at 20°C; the pressure is controlled at 0.3MPa; the lotus leaf separation component...

Embodiment 2

[0023] Take 5kg of lotus leaves, chop them into thin strips, add sea salt water, infiltrate and stack for 1 hour; move to the extraction tank, add water 3 times the weight of the raw materials, add snail enzyme and vitamins of 1% of the weight of the raw materials of lotus leaves according to 2% of the water volume C. Stir and extract at room temperature for 1 hour, filter to obtain the extract; directly load the extract, and separate it through a neutral alumina column. The mobile phase is 3% phosphoric acid solution-ethanol (1:1), and collect the eluate; Dehydration is separated by simulated moving bed chromatography, wherein the adsorbent filled by simulated moving bed chromatography is silica gel, and the eluent is 0.1% triethylamine aqueous solution; the flow rate in the adsorption zone is 2BV / h; the flow rate in the elution zone is 3BV / h; switching time The temperature is controlled at 25°C; the pressure is controlled at 0.4MPa; the lotus leaf separation component is obta...

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Abstract

The invention provides a preparation method of lotus leaf extract. The method comprises the steps of sea salt infiltration, enzyme extraction, aluminum oxide column purification, simulation moving bed refining and the like, the concentration of nuciferin in the obtained lotus leaf extract is larger than 95% by weight, and requirements of high purity nuciferin called on the international are met. According to the whole method, used materials are all conventional materials, toxic solvent is not used, operation is easy and convenient, the cost is low, the yield is high, environmental pollution can be reduced, and the method is prone to industrialization.

Description

technical field [0001] The invention relates to an efficient method for extracting nuciferine from lotus leaves, belonging to the field of natural plant extracts. Background technique [0002] The lotus leaf is the dry leaf of Nelumbo nucifera Gaertn. Traditional Chinese medicine believes that the lotus leaf is bitter and cold in nature and taste, flat, and returns to the liver, spleen, stomach, and heart meridian. According to the "Compendium of Materia Medica" it is recorded that "taking lotus leaves makes people thin and weak", "generates vitality, helps the spleen and stomach, astringent essence and turbidity, dissipates congestion, reduces swelling and pain, and causes acne". Modern pharmacological studies have shown that lotus leaf has the functions of reducing fat and losing weight, anti-oxidation, anti-aging, inhibiting fatty liver, inhibiting bacteria, inhibiting HIV proliferation, anti-virus, anti-inflammatory, and anti-allergic. The clinical application of lotus...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D221/18
CPCC07D221/18
Inventor 马亚琼赵永强徐旭高瑞贾洪涛张成亮
Owner 内蒙古昶辉生物科技股份有限公司
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