Preparation method of nerve defect repair material imitating basement membrane tube structure

Abstract

The invention discloses a preparation method of a nerve defect repair material of a vessel basilar membrane imitating structure, and belongs to the fields of a tissue engineering technology and a biological material. On the basis of the arrangement of peripheral nerve collagen fibers and the structural characteristics of a nerve fiber vessel basilar membrane, the peripheral nerve defect repair material of the vessel basilar membrane imitating structure is prepared mainly from a high polymer material and a natural material in accordance with an electro-spinning technology and a pore-forming technology. Different from other nerve conduits, the cross section of the material is represented as a porous micro-tubular structure and fiber arrangement on the tube wall is highly oriented in a direction consistent with the moving direction of microtubule. The specific surface area of the tube wall of the material is significantly improved, and the structure of the microtubule is similar to that of the nerve fiber vessel basilar membrane; a plurality of nerve growth promoting substances can be added; and the tissue engineering peripheral nerve defect repair material is good in biocompatibility and convenient for the nerve fibers to grow in the direction of principal axis of the repair material, and the repair material has an application prospect.

Description

technical field [0001] The invention relates to the technical field of bionic preparation of peripheral nerve defect repair materials, in particular to a preparation method of a nerve defect repair material imitating a basement membrane tube structure. Background technique [0002] A nerve (Nerve) is composed of nerve fibers gathered into bundles, and the nerve fibers themselves are covered by the myelin sheath formed by Schwann cells outside the axons of neurons. Many of these nerve fibers gather into bundles, which are then filled with connective tissue to form peripheral nerves. Sunderland divides nerve damage into five degrees according to the degree of nerve damage. When the damage reaches more than four degrees, that is, when the nerve bundle is severely damaged or completely severed, it seldom recovers on its own, and must rely on nerve transplantation or artificial repair materials for treatment. The repair and reconstruction of peripheral nerve defects is a major p...

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Problems solved by technology

Including the use of pore-forming technology to prepare porous nerve repair materials with tube orientation, but these improvements cannot truly simulate the fiber arrangement of the nerve basement membrane tubes. Through previous experiments, we found that the fiber structure of the basement membrane tubes is also along the long axis of the nerve aligned

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