Preparation method for hyaluronic acid, and anti-adhesive composition comprising hyaluronic acid prepared by same preparation method

A technology of hyaluronic acid and manufacturing method, which is applied in the field of manufacturing, can solve the problems of short residence time and achieve the effect of slow decomposition speed and excellent anti-adhesion effect
CN105324486AActive Publication Date: 2016-02-10IL DONG PHARMA CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
IL DONG PHARMA CO LTD
Publication Date
2016-02-10

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Abstract

The present invention relates to a preparation method for hyaluronic acid having a low degradation rate in the body, and an anti-adhesive composition comprising hyaluronic acid prepared by the preparation method. More specifically, the present invention provides a preparation method for hyaluronic acid having a low degradation rate in the body, comprising a step for culturing Streptococcus dysgalactiae strain 9103 (KCTC11818BP) in a medium comprising a carbon source and a nitrogen source, and an anti-adhesive composition comprising hyaluronic acid prepared by the preparation method. The hyaluronic acid prepared by the preparation method of the present invention is a high-molecular hyaluronic acid of 3.5 million Da to 10 million Da, and has an excellent anti-adhesive effect due to slow degradation rate in the body. The anti-adhesive composition of the present invention, comprising hyaluronic acid prepared by the preparation method of the present invention, is capable of improving the problems of conventional anti-adhesive compositions comprising crosslinking agents and compounds, and the problems of conventional hyaluronic acid, by using non-crosslinked hyaluronic acid.
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Description

technical field

[0001] This application claims the priority of Korean Patent Application No. 10-2013-0029876 (Application No.) filed on March 20, 2013, the entirety of which is hereby incorporated by reference.

[0002] The present invention relates to a method for producing hyaluronic acid having a low decomposition rate in vivo and an anti-adhesion composition containing hyaluronic acid produced by the above method. A method for producing hyaluronic acid having a low decomposition rate in vivo by culturing a strain (KCTC11818BP) in a medium containing carbon and nitrogen sources, and an anti-adhesion composition containing hyaluronic acid produced by the method. Background technique

[0003] Hyaluronic acid (Hyaluronicacid (HA), Hyaluronan, (C 14 h 20 NNaO 11 )n(n>1000)) are macromolecules present in living organisms and are polysaccharides of glycosaminoglycans. In its structure, D-glucuronic acid and N-acetylglucosamine are repeatedly linked by -1,3 bonds and -1,4...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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