Composite hydrogel and preparation method thereof

A technology of compounding hydrogels and polymerizing monomers, which is applied in the fields of pharmaceutical formulations, medical preparations with non-active ingredients, and pharmaceutical sciences. Simple and convenient, good antibacterial properties, good porosity effect

Inactive Publication Date: 2016-03-02
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the hydrogel adjuvant currently in clinical use cannot have these excellent characteristics in terms of wounds at the same time. For example, carboxymethylcellulose hydrogel dressings are easy to adhere to the wound after absorbing tissue exudate, and it is easy to cause damage when changing the dressing. secondary injury
Chitin/chitosan hydrogel dressings can only absorb water up to 4 times their

Method used

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  • Composite hydrogel and preparation method thereof
  • Composite hydrogel and preparation method thereof
  • Composite hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0019] Example 1: At room temperature (preferably 25°C), take 0.2g of [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SBMA)H 2 C=C(CH 3 )CO 2 CH 2 CH 2 N(CH 3 ) 2 (CH 2 ) 3 SO 3 And 1.2ml of PEG monomer, add 1mL of deionized water, mix well, then add 1.4uL of crosslinking agent polyethylene glycol dimethacrylate (PEGDMA) and 7.5mg of photoinitiator Irgacure2959, the number average of the crosslinking agent The molecular weight Mn is 330, and after uniform mixing, a clear mixed solution is obtained. Subsequently, the solution containing SBMA, PEG, cross-linking agent and initiator was injected into the closed mold, and irradiated with ultraviolet light for 10 minutes to initiate free radical polymerization to prepare hydrogel PEG:SBMA4:1; then, put the mold and hydrogel together Put it into deionized water, change the water every 3 hours, record the degumming time, rinse with deionized water repeatedly after degumming and soak for 5 days.

example 2

[0020] Example 2: At room temperature (preferably 25°C), take 0.3g of SBMA and 1.1ml of PEG monomer, add 1mL of deionized water, mix well, then add 1.4uL of crosslinker PEGDMA and 7.5mg of photoinitiator Irgacure2959, the crosslinker The number-average molecular weight Mn of the linking agent is 550. After uniform mixing, a clear mixed solution is obtained; then, the solution containing SBMA, PEG, cross-linking agent and initiator is injected into a closed mold, and irradiated by ultraviolet light for 20 minutes to initiate free radical polymerization. Hydrogel PEG:SBMA2:1; Then, put the mold and hydrogel into deionized water together, change the water every 3 hours for the first two days, and then change the water twice a day, record the degumming time, and use deionized water after degumming Water was repeatedly rinsed and soaked for 5 days.

example 3

[0021] Example 3: At room temperature (preferably 25°C), take 0.5g of SBMA and 0.9ml of PEG monomer, add 1mL of deionized water, mix well, then add 1.4uL of cross-linking agent PEGDMA and 7.5mg of photoinitiator Irgacure2959, after mixing evenly , the number-average molecular weight Mn of the cross-linking agent is 2000, and a clear mixed solution is obtained; subsequently, the solution containing SBMA, PEG, cross-linking agent and initiator is injected into a closed mold, irradiated by ultraviolet light for 40min, and the free radical polymerization is initiated to obtain Hydrogel PEG:SBMA1:1; Then, put the mold and hydrogel into deionized water together, change the water every 3 hours, record the degumming time, after degumming, rinse repeatedly with deionized water and soak for 5 days.

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Abstract

The invention discloses a composite hydrogel and a preparation method thereof, which utilize polyethylene glycol dimethyl acrylic esters as cross-linking agents, utilizes 2-hydroxyl-4-(2-hydroxyl ethoxy)-2-methyl propiophenone as an initiator, utilizes [2-( methacryloyloxyethyl) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide (SBMA)) and polyethylene glycol methacrylate (polyethylene glycol (PEG)) as monomer light to trigger crosslinking and compound hydrogel. The composite hydrogel with different network structures can be prepared by adjusting and controlling different radios of SBMA and PEG monomers, thereby supplying an appropriate environment (wettability, breathability and low inflammation and the like) for late delivery or tissue-engineered repair. The method for preparing the composite hydrogel is simple, and the used SBMA and the PEG are all protein non-absorbed materials and are easy for long-term preservation and long-distance transportation.

Description

technical field [0001] The present invention relates to a kind of composite hydrogel and preparation method thereof, more specifically, relate to polyethylene glycol methacrylate (i.e. PEG) and [2-(methacryloyloxy) ethyl] dimethyl -Composite hydrogel of (3-sulfonic acid propyl) ammonium hydroxide (ie SBMA) and its preparation method. Background technique [0002] After skin trauma, the main effects on wound healing are the inflammatory response period and the granulation formation period, so keeping the wound clean can effectively prevent the wound inflammatory response. Therefore, a good wound dressing can not only provide an environment conducive to wound healing, but also need to play the role of skin barrier. The main dressings in clinical application now include some traditional accessories, such as gauze; biological dressings, such as amniotic membrane and cadaver skin. The disadvantage of traditional dressing gauze is that it cannot maintain a moist environment on t...

Claims

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Application Information

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IPC IPC(8): C08F222/16C08F220/38C08F222/14C08F290/06A61L15/26A61L15/44A61L15/42A61L27/18A61L27/52A61L27/54A61K47/34
Inventor 吴疆肖泽聪肖健张宏宇李校堃陈圣福何超超
Owner WENZHOU MEDICAL UNIV
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