Gel patch promoting wound healing and preparation method thereof

Abstract

The invention discloses a gel patch promoting wound healing and a preparation method thereof. The gel patch promoting wound healing is formed by mixing 8-20% of polyvinyl alcohol, 0.1-5% of water-soluble chitosan, 1-5% of glycerin and purified water, non-woven fabric is coated with the mixture through heating, stirring and dissolving, and cooling, gel is solidified through freezing crosslinking, finally irradiation sterilization is performed, and the gel patch is obtained. The gel patch has the advantages that a gel layer contains water-soluble chitosan and glycerin and is high in content of water, a humid environment can be provided for the surface of a wound, and wound healing is promoted; the gel is obtained through disposable freezing crosslinking, and large-scale production is facilitated; the gel patch is good in biocompatibility and free of toxicity, irritation and allergenicity; the gel patch has self-adhesion performance and is easy to paste and tear and high in comfort degree, and secondary injury to a wound is avoided in the dressing changing process. The gel patch is suitable for protection and treatment of burns, scalds, trauma and the surface of a wound after an operation, has the moisture preserving, anti-microbial and anti-inflammation effect and can effectively promote wound healing and inhibit scar formation.

Description

technical field [0001] The invention relates to a gel patch for promoting wound healing and a preparation method thereof, belonging to the technical field of medical materials. Background technique [0002] Trauma is the damage of normal skin (tissue) caused by external injury factors such as surgery, external force, heat, electric current, chemical substances, low temperature, and internal factors such as local blood supply disturbance. Common traumas include surgical incisions, abrasions, burns, donor sites, decubitus ulcers, vascular ulcers of lower extremities, diabetic ulcers, and other difficult-to-heal wounds. The formation and existence of trauma will have a major impact on the local and even whole body functions of the body. In order to accelerate the healing of the wound and reduce the infection of the wound surface, dressings are generally used to cover and protect the wound. Traditional passive dressings such as gauze, cotton pads and synthetic fibers are econo...

AI Technical Summary

Problems solved by technology

The chemical cross-linking method will involve the addition of chemical reagents. The prepared hydrogel usually contains residual unreacted monomers, cross-linking agents and initiators, etc., which need to be used after complicated purification treatments, and the residual initiators , The cross-linking agent is often toxic, which seriously affects the biological safety of the product

Freezing cross-linking is an effective method for preparing polyvinyl alcohol hydrogels, but the currently reported or disclosed polyvinyl alcohol freezing and cross-linking methods all use repeated and cyclical freeze-thaw cross-linking methods, and the preparation process is cumbersome and unsuitable. industrial production

Irradiation cross-linking is to irradiate and cross-link the gel at the same time when the gel is irradiated and sterilized. However, practice has proved that the effect of radiation cross-linking is not easy to control. After the gel is irradiated, two Two kinds of results: one result is that the gel is completely degraded; the other result is that the gel is cross-linked into a semi-solid and hard; and the soft gel state between degraded and semi-solid is very difficult to control

It can be seen that the process of preparing gel by irradiation crosslinking has poor stability and is not conducive to the quality control of products.

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