Composite tissue repairing sheet and preparation method thereof

A tissue repair and composite technology, applied in the field of biomedicine, can solve the problems of loss of mechanical strength of woven mesh, decreased repair performance of electrospun membrane, difficult control of processing technology, etc., and achieves good microstructure, microstructure retention, and good repair. effect of effect

Inactive Publication Date: 2016-03-30
MEDPRIN REGENERATIVE MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since there is generally a large modulus difference between the electrospun membrane material and the woven mesh, if the conventional direct hot-pressing method is used to directly connect the electrospun membrane to the woven mesh, it is prone to weak bonding. Delamination occurs under external tension
At the same time, it is difficult to control the processing technology of the electrospun membrane and the woven mesh by direct hot pressing, and it is easy to damage the structure of the electrospun membrane or the woven mesh, resulting in a decrease in the repair performance of the electrospun membrane or a loss of the mechanical strength of the woven mesh. , the ideal composite diaphragm cannot be obtained

Method used

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  • Composite tissue repairing sheet and preparation method thereof
  • Composite tissue repairing sheet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] A method for preparing a composite tissue repair patch, comprising the following steps:

[0037] S1. Preparation of Electrospinning Film Layer A:

[0038] Dissolve PLA in hexafluoroisopropanol solution with a PLA concentration of 8% (g / ml) to obtain a homogeneous polymer solution; put the PLA solution into an electrospinning syringe and adjust the speed of the microsyringe pump to 10mL / h, adjust the voltage of the high-voltage generator to 22KV, adjust the receiving distance of the receiving device to 18cm, perform electrospinning, and close the electrospinning after reaching a thickness of 0.3mm to obtain a PLA electrospinning film layer.

[0039] S2. Preparation of electrospun membrane B:

[0040] Dissolve PCL in hexafluoroisopropanol solution, the concentration of PCL is 20% (g / ml), to obtain a uniform polymer solution, put the PCL solution into the electrospinning syringe, and adjust the speed of the micro syringe pump to 4mL / h, adjust the voltage of the high-...

Embodiment 2

[0044] A method for preparing a composite tissue repair patch, comprising the following steps:

[0045] S1. Preparation of Electrospinning Film Layer A:

[0046] Dissolve PLA in hexafluoroisopropanol solution with a PLA concentration of 6% (g / ml) to obtain a homogeneous polymer solution; put the PLA solution into an electrospinning syringe and adjust the speed of the micro-syringe pump to 8mL / h, adjust the voltage of the high-voltage generator to 20KV, adjust the receiving distance of the receiving device to 20cm, perform electrospinning, and close the electrospinning after reaching a thickness of 0.3mm to obtain PLA electrospinning film layer A.

[0047] Repeat once to prepare two PLA electrospun film layers A in total.

[0048] S2. Preparation of electrospun membrane B:

[0049] Dissolve PCL in hexafluoroisopropanol solution, the concentration of PCL is 18% (g / ml), to obtain a uniform polymer solution, put the PCL solution into the electrospinning syringe, adjust the spee...

Embodiment 3

[0055] A method for preparing a composite tissue repair patch, comprising the following steps:

[0056] S1. Preparation of Electrospinning Film Layer A:

[0057] Dissolve PLA in hexafluoroisopropanol solution with a PLA concentration of 6% (g / ml) to obtain a homogeneous polymer solution; put the PLA solution into an electrospinning syringe and adjust the speed of the micro-syringe pump to 8mL / h, adjust the voltage of the high-voltage generator to 20KV, adjust the receiving distance of the receiving device to 20cm, perform electrospinning, and close the electrospinning after reaching a thickness of 0.3mm to obtain PLA electrospinning film layer A.

[0058] Repeat once to prepare two PLA electrospun film layers A in total.

[0059] One piece of PLA electrospun film layer A is loaded with chitosan anti-adhesion material.

[0060] S2. Preparation of electrospun membrane B:

[0061] Dissolve P4HB in chloroform solution, the concentration of P4HB is 5% (g / ml), to obtain a unif...

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Abstract

The invention discloses a composite tissue repairing sheet and a preparation method thereof. The composite tissue repairing sheet comprises an electrostatic spinning film layer, a bonding layer and a woven mesh layer; the electrostatic spinning film layer is prepared from a material A, the bonding layer is prepared from a material B through electrostatic spinning, and the hot melting temperature of the material B is lower than the hot melting temperature of the material A; and the bonding layer is disposed between the electrostatic spinning film layer and the woven mesh layer, and the bonding layer is heated and melt through hot press, and thus the electrostatic spinning film layer is bonded with the woven mesh layer. The prepared composite tissue repairing sheet possesses good mechanical properties of a woven mesh and the three-dimensional porous structure and the soft characteristic of the electrostatic spinning film, facilitates to promote rapid growth of cell in the sheet, and possesses relatively good fusion property with hyperplastic tissue.

Description

technical field [0001] The invention relates to the field of biomedicine, and more specifically relates to a composite tissue repair patch and a preparation method thereof. Background technique [0002] Electrospun membranes have a wide range of applications in tissue repair, but due to their limitations in strength, there are few reports on applications in diseases that require high material strength, such as abdominal hernias and rotator cuffs. The main material currently used for the above two diseases is still a woven mesh. However, although the woven mesh has good mechanical properties, it has defects such as high hardness, rough surface, easy adhesion with tissue, and poor integration with tissue in promoting tissue repair, making it difficult to achieve an ideal repair effect. Therefore, there is a need for a composite tissue repair patch that combines the mechanical strength advantages of woven mesh and the advantages of electrospun membranes in promoting tissue rep...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/18A61L27/16A61L27/50A61L27/56
CPCA61L27/16A61L27/18A61L27/50A61L27/56A61L2430/34C08L67/04C08L23/12
Inventor 郭泽跃赖奎霖王国帅袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH
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