A mesoporous magnetic polymer composite sphere, a preparing method thereof and applications of the composite sphere

A technology of water-soluble polymers and composite spheres, which is applied in the preparation methods of peptides, chemical instruments and methods, and alkali metal compounds, etc., and can solve the problems of reducing magnetic responsiveness, magnetic content of composite microspheres, and lower specific saturation magnetization , to achieve high saturation magnetization, good product stability, and low equipment requirements

Active Publication Date: 2016-03-30
SICHUAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although there are many reports on the use of inorganic materials or polymer materials to wrap superparamagnetic nanoparticles to form composite microspheres, the magnetic content and specific saturation magnetization of the composite microspheres are low due to the shielding effect of the coating materials. Reduces its magnetic responsivity, thus limiting its application

Method used

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  • A mesoporous magnetic polymer composite sphere, a preparing method thereof and applications of the composite sphere
  • A mesoporous magnetic polymer composite sphere, a preparing method thereof and applications of the composite sphere
  • A mesoporous magnetic polymer composite sphere, a preparing method thereof and applications of the composite sphere

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1 Preparation of Mesoporous Magnetic Polymer Composite Balls

[0045] (1) Fe 3 o 4 Preparation of Superparamagnetic Nanoparticle Suspensions

[0046] Fe 3 o 4 Nanoparticles were synthesized using the traditional co-precipitation method by Fe +2 , Fe +3 Synthesized by co-precipitation with ammonia water. Produced Fe 3 o 4 Dispersed in a certain volume of water to obtain 10mg / ml of Fe 3 o 4 The suspension is ready for use.

[0047] (2) Take 5ml of the above Fe 3 o 4 The suspension was stirred with 5ml of carboxylated chitosan (CMCS) aqueous solution with a concentration of 5mg / ml for 12 hours to obtain Fe with good water solubility 3 o 4 CMCS nanoparticle suspension.

[0048] (3) Add 200ul of the above Fe 3 o 4 The CMCS nanoparticle suspension was added to 10ml liquid paraffin containing 3mlspan80, homogenized and dispersed (4000rpm, 10min) to obtain water-in-oil hybrid droplets.

[0049] (4) Add 25mg of genipin, 1000rpm, 60°C, stir for 4 hours...

Embodiment 2

[0058] (1) Fe 3 o 4 Preparation of Superparamagnetic Nanoparticle Suspensions

[0059] Fe 3 o 4 Nanoparticles were synthesized using the traditional co-precipitation method by Fe +2 , Fe +3 Synthesized by co-precipitation with ammonia water. Produced Fe 3 o 4 Dispersed in a certain volume of water to obtain 10mg / ml of Fe 3 o 4 The suspension is ready for use.

[0060] (2) Take 5ml of the above Fe 3 o 4 The suspension was stirred with 5ml of acrylic acid aqueous solution with a concentration of 5mg / ml for 12 hours to obtain Fe with better water solubility 3 o 4 Acrylic Nanoparticle Suspension.

[0061] (3) Add 200ul of the above Fe 3 o 4 The suspension of acrylic acid nanoparticles was added to 10ml of liquid paraffin containing 3mlspan80, homogenized and dispersed (4000rpm, 10min) to obtain water-in-oil hybrid droplets.

[0062] (4) Add 25mg of ammonium persulfate (APS), 1000rpm, 60°C, stir for 4 hours to initiate acrylic acid polymerization, stabilize the emu...

Embodiment 3

[0067] (1) Preparation of superparamagnetic nanoparticle suspension

[0068] superparamagnetic Fe 2 o 3 Disperse in a certain volume of water to obtain 10mg / ml Fe 2 o 3 The suspension is ready for use.

[0069] (2) Take 25ml of the above Fe 2 o 3 The suspension was stirred with 50 ml of chitosan (CS) aqueous solution with a concentration of 5 mg / ml for 6 hours. Produces Fe with better water solubility 2 o 3 CS nanoparticle suspension.

[0070] (3) Add 1ml of the above Fe 2 o 3 The CS nanoparticle suspension was added to 10ml liquid paraffin containing 6mlspan80, homogenized and dispersed (2000rpm, 5min) to obtain water-in-oil hybrid droplets.

[0071] (4) Add 50mg of glutaraldehyde, 1000rpm, 60°C, stir for 4h, cross-link chitosan, stabilize the emulsification system, and gradually form mesoporous CS / Fe 2 o 3 compound ball.

[0072] The product is characterized by the same method as in Example 1, and the results show that the obtained product is the same as the CM...

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Abstract

The invention discloses a mesoporous magnetic polymer composite sphere, a preparing method thereof and applications of the composite sphere. The composite sphere comprises superparamagnetic nanometer particles and water-soluble polymer cover layers. The superparamagnetic nanometer particles are covered with the water-soluble polymer cover layers. After emulsification and crosslinking, a large number of the superparamagnetic nanometer particles are tightly stacked to form a sphere shape. The composite sphere is in a mesoporous structure. The composite sphere is high in magnetic content and specific saturation magnetization, mild in preparation conditions, good in product stability and convenient for popularization and application, and can effectively perform protein separation.

Description

technical field [0001] The invention belongs to the field of biological materials and relates to a mesoporous magnetic polymer composite ball. technical background [0002] Superparamagnetic nanoparticles are widely used in magnetic resonance imaging, biological separation (cell separation, protein separation) etc.), drug delivery systems, magnetic hyperthermia and gene therapy and other biomedical aspects. Due to the small particle size of superparamagnetic nanoparticles, when used for biological separation, the magnetic force generated under the action of a magnetic field is also very small, and it needs to be under a strong magnetic field or for a long time to achieve a good separation effect. . At present, some researchers have made composite microspheres by mixing superparamagnetic nanoparticles with polymers to increase the magnetic force generated under the action of a magnetic field and improve the separation efficiency. [0003] Although there are many reports on...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/28B01J20/30C07K1/22
Inventor 吴尧蓝芳杨琦顾忠伟
Owner SICHUAN UNIV
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