Surface carboxyl-functionalized core-shell type magnetic composite microballoons and preparation method thereof

A technology of magnetic composite microspheres and carboxyl functionalization, which is applied in the field of functional materials to achieve the effects of controllable thickness and crosslinking degree, high magnetic content, and regular structure

Inactive Publication Date: 2013-11-27
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method can be used without a transition layer, it can only be used to prepare composite microspheres with a hydrophobic shell.

Method used

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  • Surface carboxyl-functionalized core-shell type magnetic composite microballoons and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: Core-shell Fe with a shell thickness of about 30 nm and a crosslinking degree of 20% 3 o 4 / Preparation of PMAA microspheres

[0024] 1. Preparation of citric acid-stabilized magnetic clusters

[0025] 1.2g ferric chloride hexahydrate (FeCl 3 ·6H 2 O), 2.4g ammonium acetate (NH 4 Ac), after dissolving 0.3g citric acid in 70ml ethylene glycol, put it into a 150ml three-neck flask, then raise the temperature to 120°C, keep it warm for 1 hour, then transfer the liquid in the flask to a 100ml Teflon liner In a high-pressure reaction kettle, put the reaction kettle into an oven at 200°C for 24 hours, take it out, and cool it to room temperature with tap water. The product is separated by magnetic separation, washed with absolute ethanol to remove unreacted reactants, and finally the product is dispersed in absolute ethanol for later use.

[0026] 2. Active vinyl modification on the surface of magnetic clusters

[0027] Add the magnetic clusters obtained ab...

Embodiment 2

[0030] Example 2: The core-shell Fe with a shell thickness of about 60 nm and a crosslinking degree of 20% 3 o 4 / Preparation of PMAA microspheres

[0031] 1. The preparation of citric acid-stabilized magnetic clusters is the same as described in Example 1-1.

[0032] 2. Carrying out active vinyl modification on the surface of magnetic clusters is the same as that described in Examples 1-2.

[0033] 3. Core-shell Fe 3 o 4 / PMAA was prepared as described in Examples 1-3. The difference is that methacrylic acid, N, N' The dosages of -methylenebisacrylamide and 2,2-azobisisobutyronitrile are 2ml, 500mg, and 40mg, respectively.

Embodiment 3

[0034] Example 3: The shell thickness is about 30nm, and the cross-linking degree is 10% core-shell Fe 3 o 4 / Preparation of PMAA microspheres

[0035] 1. The preparation of citric acid-stabilized magnetic clusters is the same as described in Example 1-1.

[0036] 2. Carrying out active vinyl modification on the surface of magnetic clusters is the same as that described in Examples 1-2.

[0037] 3. Core-shell Fe 3 o 4 / PMAA was prepared as described in Examples 1-3. The difference is N, N' - The amount of methylenebisacrylamide used is 110 mg.

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Abstract

The invention specifically relates to surface carboxyl-functionalized core-shell type magnetic composite microballoons and a preparation method thereof, belonging to the technical field of functional materials. According to the invention, the core of the core-shell type magnetic composite microballoons is a magnetic ferriferrous oxide nanoparticle cluster, and the shell of the microballoons is a cross-linked carboxyl-containing polymer network. The preparation method comprises the following steps: at first, preparing the citric acid stabilized magnetic nanoparticle cluster (thereafter referred as magnetic cluster for short); then, modifying the surface of the magnetic cluster with active vinyl function groups by using the sol-gel method; finally, preparing the monodisperse core-shell type magnetic polymer composite microballoons which have high magnetic responsibility and contain abundant active carboxyl groups on their surface through distillation-precipitation polymerization. A variety of bioactive molecules can be bonded with the surface of the core-shell type microballoons through chemical modification for application in the field of biomedicine. Furthermore, the method can accurately control the thickness and cross-linking degree of the shell of polymers. The invention has the advantages of simple operation and controllable process and has a good application prospect.

Description

technical field [0001] The invention belongs to the technical field of functional materials, and in particular relates to a core-shell magnetic composite microsphere and a preparation method thereof. Background technique [0002] In recent years, multifunctional nanomaterials, especially magnetic composite microspheres, have received widespread attention. Since the magnetic composite microspheres have both the magnetism of inorganic magnetic substances and the surface modifyability of organic polymers, they can quickly, conveniently and efficiently separate target bioactive molecules under the action of a magnetic field, so that they can be used in cell separation, protein purification, magnetic resonance, etc. Detection, magnetically targeted drug loading and other fields have good application prospects. From the perspective of application, for rapid separation and magnetic resonance detection, ideal magnetic microspheres should have uniform particle size, high magnetic re...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F292/00
Inventor 汪长春马万福唐倩倩
Owner FUDAN UNIV
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