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Multilayer composite film dressing and preparation method thereof

A multi-layer composite film and film layer technology, applied in the field of composite film, can solve problems such as singleness, functional limitations, non-complementary functions or simultaneous existence, etc., to achieve simple operation steps, easy to master the operation process, considerable potential applications and commercial value Effect

Inactive Publication Date: 2016-04-20
POLYU RES BASE SHENZHEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, when the nanofibrous membranes reported or produced are used in wound dressings, there are often some shortcomings: their functions are relatively limited or single, and the functions cannot be complementary or exist at the same time

Method used

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  • Multilayer composite film dressing and preparation method thereof
  • Multilayer composite film dressing and preparation method thereof
  • Multilayer composite film dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1 (polyurethane cast film+gelatin nanofiber film):

[0033] Weigh 0.78g of polyurethane with a molecular weight of 200,000, and 0.078g of amoxicillin, and dissolve them together in 8.5g of dimethylformamide solvent, and then form a film of 10*10cm. Afterwards, 1.0 g of gelatin with a molecular weight of 30,000 and a Bloom value of 200 was weighed, dissolved in 5 g of formic acid solvent, and fibers were collected on the polyurethane film by electrospinning technology. The electrospinning parameters were: voltage of 15 kv, nozzle and collecting plate The distance is 10cm, the rotation speed of the collecting plate is 10rpm, the flow rate is 2ml / h, the temperature is 22±2°C, and the humidity is 35±3%. Finally, the environment is naturally dry.

Embodiment 2

[0034] Embodiment 2 (polyurethane nanofiber membrane+gelatin nanofiber membrane):

[0035]Weigh 1.0 g of polyurethane with a molecular weight of 100,000 and 0.1 g of ampicillin, and dissolve them together in 10 g of dimethylformamide solvent. The obtained homogeneous solution is used to prepare polyurethane thin nanofiber membranes by electrospinning technology. The electrospinning parameters are: The voltage is 10kv, the distance between the nozzle and the collecting plate is 15cm, the rotation speed of the collecting plate is 100rpm, the flow rate is 1ml / h, the temperature is 30±2°C, and the humidity is 30±2%. Afterwards, 0.8g of gelatin with a molecular weight of 50,000 and a Bloom value of 300 was weighed, dissolved in 6g of water, and continuously electrospun directly on the above-mentioned polyurethane thin nanofiber membrane. 20cm, collection plate rotation speed 20rpm, flow rate 1ml / h, temperature 30±2°C, humidity 30±2%, the obtained gelatin nanofiber membrane was cros...

Embodiment 3

[0036] Embodiment 3 (polyurethane nanofiber film+gelatin casting film):

[0037] Weigh 1.2g of polyurethane with a molecular weight of 150,000, and 0.06g of silver nitrate, and dissolve them together in 20g of dimethylacetamide solvent. The obtained homogeneous solution is used to prepare polyurethane thin nanofiber membranes by electrospinning technology. The electrospinning parameters are: The voltage is 15kv, the distance between the nozzle and the collecting plate is 15cm, the rotation speed of the collecting plate is 50rpm, the flow rate is 4ml / h, the temperature is 28±2℃, and the humidity is 40±3%. Afterwards, 0.6 g of gelatin with a molecular weight of 50,000 and a Bloom value of 100 was weighed, dissolved in 10 g of water, and a 10*10 cm film was formed directly on the polyurethane thin nanofiber membrane by casting method, and then crosslinked with glutaraldehyde for 12 hours. Finally, the environment is naturally dry.

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Abstract

The invention discloses a multilayer composite film dressing, which comprises a gelatin layer and a polyurethane layer. The gelatin film layer and / or the polyurethane film layer are / is a nano-fiber material. The polyurethane film layer includes an antibacterial component. The preparation method of the multilayer composite film dressing consists of the step of continuous preparation of the polyurethane film layer or gelatin film layer with a well prepared gelatin film layer or polyurethane film layer as the substrate, or includes the step of hot-pressing of the gelatin film layer and the polyurethane film layer respectively. The multilayer composite film dressing provided by the invention has a multilayer structure, different layers have no interference to each other and can cooperate with each other to complete a variety of functions, so that the multilayer composite film dressing has good broad-spectrum antibacterial activity, hemostatic properties, air permeability, cell compatibility, liquid absorption rate, surface waterproof performance, water vapor permeability and other performance. The preparation method of the multilayer composite film dressing has very simple operation steps, and at the same time the operation process is very easy to grasp.

Description

technical field [0001] The invention relates to the field of polymer film materials, in particular to a composite film that can be used as a medical wound dressing. Background technique [0002] Most of the current dressings in my country are at the middle and low-end level, and the international bargaining power is low. At present, there are more than 300 varieties of high-end new medical dressings, which can be roughly divided into four categories: high-end moist dressings (mainly including foam, hydrocolloid, transparent film, hydrogel, seaweed, and hydrated fiber), antibacterial dressings (mainly including Silver, zinc, iodine, natural product additives, antibacterial polymers, antibiotics), vacuum closure wound treatment VAC and nanofiber dressings. However, the current global high-end biomedical dressing market is mainly occupied by more than 30 companies in Europe and the United States (41% in Europe and 39% in North America), such as 3M, AcryMed, Inc., Coloplast, Ke...

Claims

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Application Information

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IPC IPC(8): A61L15/32A61L15/26A61L15/44
Inventor 胡金莲谭淋韩建平
Owner POLYU RES BASE SHENZHEN
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