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Fermentation traditional Chinese medicine combination for liquid shampoo and preparation method and application of combination

A technology of composition and shampoo, applied in the direction of pharmaceutical formulations, cosmetic preparations, skin care preparations, etc., can solve the problems of scalp damage, large manpower and material resources, long cycle, etc., to inhibit growth and improve antibacterial effect of effect

Active Publication Date: 2016-05-04
SANZHU FUER PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the anti-dandruff shampoos contain chemical anti-dandruff agents and fungicides, such as ketoconazole, zinc pyridine sulfate, campanolin and other ingredients. The chemical ingredients are more harmful to the scalp and are prone to drug resistance.
It is particularly important to develop an anti-Malassezia shampoo with high efficiency and low toxicity, but synthesizing a new antifungal compound requires a long period of labor and material resources.

Method used

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  • Fermentation traditional Chinese medicine combination for liquid shampoo and preparation method and application of combination
  • Fermentation traditional Chinese medicine combination for liquid shampoo and preparation method and application of combination
  • Fermentation traditional Chinese medicine combination for liquid shampoo and preparation method and application of combination

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026]The preparation of embodiment 1 fermented Chinese medicine composition A

[0027] Weigh each medicinal material according to the following weight: Sophora flavescens 18g, safflower 13g, Cnidium 13g, Chuanjiao 12g, Coptis 20g, Cortex Phellodendron 14g, Scutellaria baicalensis 10g, take Sophora flavescens, safflower, Cnidium chinensis, Sichuan pepper and crush them, pass 40 Mesh sieve, add water 10 times the weight of the medicinal material, soak for 1.0 hour, adjust the pH value to 7.0, sterilize at 115°C for 50 minutes, when the temperature drops to 33°C, insert the pre-cultured Bacillus subtilis subsp. AS1.210), the inoculation amount is 3% (volume / volume), cultured at 32°C for 22 hours, and then inserted into the pre-cultivated Saccharomyces ochraceae (AS2.2114) and Saccharomyces cerevisiae (AS2.3852) strains , the inoculum size is 2% (volume / volume), the culture temperature is 30°C, ferment for 30 hours, heat to 100°C, and keep for 10 minutes, centrifuge to take the s...

Embodiment 2

[0028] The preparation of embodiment 2 fermented Chinese medicine composition B

[0029] Weigh each medicinal material according to the following weight: Sophora flavescens 18g, safflower 13g, Cnidium 13g, Chuanjiao 12g, Coptis 20g, Cortex Phellodendron 14g, Scutellaria baicalensis 10g, take Sophora flavescens, safflower, Cnidium chinensis, Sichuan pepper and crush them, pass 40 Mesh sieve, add water 10 times the weight of the medicinal material, soak for 1.0 hour, adjust the pH value to 7.0, sterilize at 115°C for 50 minutes, when the temperature drops to 33°C, insert the pre-cultured Bacillus subtilis subsp. AS1.210), the inoculation amount is 3% (volume / volume), cultured at 32°C for 22 hours, and then inserted into the pre-cultivated Saccharomyces ochraceae (AS2.2114) and Saccharomyces cerevisiae (AS2.3852) strains , the inoculum amount is 2% (volume / volume), culture temperature is 30°C, ferment for 30 hours, heat to 100°C, and keep for 10 minutes, centrifuge to take the su...

Embodiment 3

[0030] The preparation of embodiment 3 fermented Chinese medicine composition C

[0031] Weigh each medicinal material according to the following weight: Sophora flavescens 13g, safflower 10g, Cnidium 12g, Chuanjiao 16g, Coptis 25g, Cortex Phellodendron 10g, Scutellaria baicalensis 14g, take Sophora flavescens, safflower, Cnidium chinensis, Sichuan pepper and crush them, pass 40 Mesh sieve, add water 10 times the weight of medicinal materials, soak for 1.0 hours, adjust the pH value to 7.0, sterilize at 115°C for 50 minutes, when the temperature drops to 33°C, insert the pre-cultured Bacillus subtilis (isolated from natto) , the inoculum volume was 3% (volume / volume), cultured at 32°C for 24 hours, and then inserted into the pre-cultivated Kluveromyces (AS2. 2% (volume / volume) culture temperature 30°C, ferment for 36 hours, heat to 100°C, and keep for 10 minutes, centrifuge to take supernatant, set aside. Add the precipitate to 85% ethanol 10 times the weight of the dregs, he...

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PUM

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Abstract

The invention discloses a fermentation traditional Chinese medicine combination for liquid shampoo and a preparation method of the combination. The fermentation traditional Chinese medicine combination is prepared after traditional Chinese medicines of lightyellow sophora root, safflower flower, common cnidium fruit and pricklyash peel are fermented by bacillus subtilis and yeaster, combined with amur corktree bark, rhizome of Chinese goldthread and baical skullcap root extracts and added into a chitosan-acetic acid solution. The fermentation traditional Chinese medicine combination can be used for preparing anti-scurf shampoo products. Experiments show that the shampoo products comprising the fermentation traditional Chinese medicine combination have remarkable inhibiting effects on malassezia fufur and remarkable efficacy for curing seborrheic dermatitis.

Description

technical field [0001] The invention relates to the application in the field of daily chemicals of a traditional Chinese medicine fermentation composition jointly prepared by fermenting traditional Chinese medicine with bacillus subtilis and yeast and extracts of traditional Chinese medicine, and belongs to the technical field of biological fermentation. Background technique [0002] Dandruff is a common disease of the scalp, medically known as "pityriasis scalp", clinically manifested as excessive small off-white dry or slightly greasy chaff-like flakes on the scalp or hair, which may be accompanied by itching, and the incidence rate of the population is high. Modern medical research shows that abnormal dandruff is formed because of a lipophilic yeast fungus resident on the surface of human skin. Under normal circumstances, natural metabolic dandruff is not easy to observe. However, if the scalp metabolism is too fast, the oil secretion is unbalanced, or the cell maturation...

Claims

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Application Information

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IPC IPC(8): A61K8/99A61K8/97A61Q5/02A61Q5/00A61Q17/00
CPCA61K8/97A61K8/99A61K2800/85A61Q5/002A61Q5/02A61Q17/005
Inventor 吴炳新孙筱林褚新红王静吕美
Owner SANZHU FUER PHARMA
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