Artificial dermal scaffold and production method thereof

Abstract

The invention discloses an artificial dermal scaffold and a production method thereof. The artificial dermal scaffold comprises a porous scaffold produced from oxycellulose and a cross-linking agent, the amount of porosity of the porous scaffold is 85-96%, the average aperture is 50-200[mu]m, the water absorption rate is 17-28 times the self weight of the porous scaffold, and the saturated water content is 90-97%. The artificial dermal scaffold is similar to human body skins in softness, can keep good three dimensional form and strength in a wet state, can cling to wounds, has good adhesiveness and breathability, can absorb human body diffusate and has no untoward effects. The artificial dermal scaffold has appropriate aperture size and porosity amount, can effectively promote wound healing, and also can promote generation of granulation tissues and new vessels. The artificial dermal scaffold also has an appropriate degradation time, and can reduce formation of scars.

Description

technical field [0001] The invention relates to the field of biomedicine, and more specifically relates to an artificial dermis support and a preparation method thereof. Background technique [0002] As the largest organ of the human body, the skin has the functions of retaining moisture, ventilating and preventing bacterial invasion. When the skin is damaged by factors such as trauma, burns or diseases, especially when a large area of ​​skin is seriously damaged, it will pose a serious threat to the life safety of the patient. The prior art mostly adopts the method of autologous skin transplantation at present, which not only causes new wound defect in the skin donor area of ​​the patient, but also is often limited by the source of skin donor. Therefore, researchers from various countries are devoted to the research of artificial skin, and only a few developed countries have mastered this technology and realized industrialization, including Integra, Dermagraft, AlloDerm, B...

AI Technical Summary

Problems solved by technology

[0004] The current artificial dermal scaffold mimics the three-dimensional structure of collagen fibers. Studies have found that the scaffold material with dense pores has good anti-scar effect, but it will limit the rapid arrival of dermal fibroblasts to the wound site, resulting in poor permeability of the dermal scaffold and slow vascularization rate. The anti-infection effect is not good; the scaffold material with loose pores is conducive to the rapid growth of blood vessels and fibroblasts, but the anti-scar effect is poor in the later stage

In addition, it is also very important for the scaffold material to maintain a complete three-dimensional structure and proper degradation time in a wet state. The scaffolds prepared by some processes are easy to dissolve, collapse or degrade in a short period of time in a wet state, making newborns Before the tissue grows in, the scaffold structure does not exist, so it cannot support cells and blood vessels well

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