A kind of synthetic method of indenonoimidazopyridine compound

A technology for imidazopyridine and ketone compounds, which is applied in organic chemistry and other fields, can solve problems such as reports and no compound synthesis methods, and achieve the effects of simple reaction operation, avoiding resource waste and environmental pollution, and wide application range
CN105585566BActive Publication Date: 2017-12-29HENAN NORMAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
HENAN NORMAL UNIV
Publication Date
2017-12-29

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Abstract

The invention discloses a method for synthesizing indene ketone and imidazole and pyridine compounds. The method comprises the steps that 2-(2- bromophenyl) imidazole [1, 2-alpha] pyridine or a derivative thereof is dissolved in solvent, then catalysts, ligands and alkali are added, a reaction is conducted in oil bath at the temperature of 120-160 DEG C under the atmosphere of 1atm of CO, and the 11H-indene [1', 2': 4, 5] imidazole [1, 2-alpha] pyridine-11-ketone compounds are obtained. The synthesis process is simple and efficient, a series-connection reaction under catalysis of transition metal is utilized, the indene ketone and imidazole and pyridine compounds are obtained through one step, in other words, an indene ketone structure is constructed while indanone and an imidazole and pyridine structural unit are linked together, resource waste and environmental pollution caused by application of multiple types of reagent andpurification treatment of the ligands in all steps of the reaction and the like in multiple steps of the reaction are avoided, raw materials are easy to prepare, the reaction is easy and convenient to operate, and the adaptability range of a substrate is wide.
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Description

technical field

[0001] The invention belongs to the technical field of organic synthesis, and in particular relates to a synthesis method of indenonoimidazopyridine compounds. Background technique

[0002] Indanone compounds not only widely exist in natural products, medicines and other biologically active molecules, but also are very important intermediates in organic synthesis, and are widely used in the production of fine organic chemicals, such as the preparation of dyes, photochromic, organic light-emitting materials, etc. Among them, it has high economic value. Therefore, indanone compounds have very important applications in biomedicine and industry. On the other hand, imidazopyridine, as an important class of nitrogen-containing fused heterocyclic rings, not only shows strong biological activity, but also is the main structural unit of some drugs (such as: anti-HIV drug GSK812397, vasodilator drug Oprinone, etc.) , and has been widely used in the fields of biologic...

Claims

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